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Xaciato
Xaciato (generic name: clindamycin phosphate vaginal gel, 2%) is an antibiotic used to treat bacterial vaginosis (BV) in adult women. It belongs to the lincosamide class of antibiotics, and it works by inhibiting bacterial protein synthesis, thereby stopping the growth of harmful bacteria responsible for causing infections in the vaginal area. Xaciato is applied directly to the vagina as a gel to target and treat the infection locally.
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Frequently Asked Questions
How long does it take for Xaciato to work?
Most patients begin to notice symptom relief within a few days of starting treatment, but it is important to complete the full 7-day course to ensure the infection is fully treated.
Can I have sex while using Xaciato?
It is recommended to avoid sexual intercourse during treatment with Xaciato to prevent reducing the effectiveness of the medication and to prevent spreading the infection.
What should I do if I miss a dose of Xaciato?
If you miss a dose, apply it as soon as you remember. If it's near the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
Can I use Xaciato if I’m pregnant?
Xaciato is categorized as pregnancy category B, meaning it should only be used during pregnancy if clearly needed. Consult your healthcare provider to determine if it is safe for you.
Is Xaciato safe for long-term use?
Xaciato is intended for short-term use to treat bacterial vaginosis. Long-term use of antibiotics can lead to resistance and secondary infections, so it should be used only as prescribed by your healthcare provider.
Comprehensive Drug Guide
How Does Xaciato Work?
Xaciato works by inhibiting bacterial protein synthesis. Clindamycin binds to the 50S ribosomal subunit of susceptible bacteria, which prevents the bacteria from producing essential proteins needed for their growth and survival. By stopping bacterial growth, Xaciato helps eliminate the infection and restore balance in the vaginal microbiome.
Common Dosages
- Xaciato is supplied in a single-dose, pre-filled applicator containing 2% clindamycin phosphate vaginal gel. One full applicator (5 grams) is administered once daily.
Typical Dosing
- Adults: One applicator full (5 grams of vaginal gel containing 2% clindamycin phosphate) is inserted into the vagina once daily, preferably at bedtime, for 7 consecutive days.
Typical Dosing
FDA Approved Indications
- Treatment of bacterial vaginosis (BV) in adult women.
Who Shouldn't Take Xaciato?
- Known hypersensitivity to clindamycin or lincomycin, or any other components of the formulation.
- History of colitis associated with clindamycin or lincomycin use.
Advice From The Pharmacist
- Apply Xaciato using the pre-filled applicator provided. Insert one full applicator into the vagina before bedtime for 7 days.
- Avoid engaging in sexual intercourse while using Xaciato to prevent reduced effectiveness and reduce the risk of passing the infection to your partner.
- Avoid using other vaginal products, including tampons, douches, or spermicides, during treatment.
- If you miss a dose, apply it as soon as you remember, but if it's close to your next scheduled dose, skip the missed dose and continue your regular dosing schedule.
Side Effects of Xaciato
Common Side Effects
- Vaginal itching or irritation
- Burning sensation during application
- Vaginal discharge
- Abdominal pain
Uncommon/Severe Side Effects
- Clostridium difficile-associated diarrhea (CDAD), which can occur after using antibiotics like clindamycin.
- Severe allergic reactions such as rash, swelling, or difficulty breathing.
Risks and Warnings of Xaciato
- Clostridium difficile-Associated Diarrhea (CDAD): Use of antibiotics like Xaciato may increase the risk of CDAD, which can cause severe diarrhea. If persistent or bloody diarrhea occurs, discontinue use and contact your healthcare provider.
- Allergic Reactions: Xaciato may cause serious allergic reactions in people sensitive to clindamycin or lincomycin. Discontinue use if any signs of an allergic reaction, such as rash or difficulty breathing, occur.
- Secondary Infections: Prolonged use of antibiotics can lead to secondary infections, such as yeast infections. Report any new symptoms, such as itching or thick discharge, to your healthcare provider.
Interactions with Xaciato
Common Drug Interactions
- Vaginal products: Avoid using vaginal products like tampons, douches, or spermicides while using Xaciato, as these can reduce the effectiveness of the treatment.
- Oral clindamycin: Use of other clindamycin products simultaneously may increase the risk of systemic side effects. Always consult your healthcare provider before combining treatments.
Alternatives to Xaciato
- Metronidazole (vaginal gel): Another antibiotic used to treat bacterial vaginosis.
- Clindamycin (oral): Systemic antibiotic therapy for more severe cases of bacterial vaginosis.
- Tinidazole (oral): An oral antibiotic used to treat bacterial vaginosis.
- Secnidazole (oral): A single-dose oral antibiotic used to treat bacterial vaginosis.
