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Wynzora
Wynzora (combination of calcipotriene and betamethasone dipropionate) is a topical cream used to treat plaque psoriasis in adults. It combines a vitamin D analog (calcipotriene), which helps regulate skin cell growth, and a corticosteroid (betamethasone), which reduces inflammation. Wynzora is designed for once-daily application to help manage the symptoms of plaque psoriasis, such as redness, itching, and scaling.
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Frequently Asked Questions
How long does it take for Wynzora to work?
Most patients begin to notice improvements in their psoriasis symptoms within 2 weeks, but it may take up to 4 to 8 weeks for full results.
Can Wynzora be used on the face?
No, Wynzora is not recommended for use on the face or sensitive areas like the underarms or groin unless directed by a healthcare provider.
Can I use Wynzora long-term?
Wynzora is typically prescribed for short-term use due to the potential side effects of long-term corticosteroid use, such as skin thinning. Consult your doctor about the duration of treatment.
What should I do if I miss a dose of Wynzora?
If you miss a dose, apply it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Wynzora safe for pregnant or breastfeeding women?
Consult your healthcare provider before using Wynzora if you are pregnant or breastfeeding, as the safety of this medication in these populations has not been fully established.
Comprehensive Drug Guide
How Does Wynzora Work?
Wynzora works by combining two active ingredients. Calcipotriene helps regulate the growth of skin cells and reduces the overproduction of cells associated with plaque psoriasis. Betamethasone dipropionate reduces inflammation, itching, and redness by suppressing the immune response in the affected skin area. This combination effectively addresses both the inflammation and rapid skin turnover characteristic of plaque psoriasis.
Common Dosages
- Topical cream containing 0.005% calcipotriene and 0.064% betamethasone dipropionate.
Typical Dosing
- Apply once daily to the affected areas of the skin. Use the cream as directed by your healthcare provider, and avoid using it on the face, underarms, or groin areas unless instructed.
Typical Dosing
FDA Approved Indications
- Treatment of plaque psoriasis in adults.
Who Shouldn't Take Wynzora?
- Known hypersensitivity to calcipotriene, betamethasone, or any other components of the formulation.
- Severe liver or kidney impairment (without doctor supervision).
- Viral, fungal, or bacterial skin infections unless otherwise directed by a healthcare provider.
Advice From The Pharmacist
- Apply a thin layer of Wynzora to clean, dry skin. Avoid using it on the face or sensitive areas like the underarms unless instructed by your doctor.
- Do not use more than the prescribed amount, as overuse can lead to skin thinning and other corticosteroid-related side effects.
- Wash your hands after applying Wynzora unless treating your hands.
- Avoid excessive exposure to sunlight or artificial UV rays, as Wynzora may make your skin more sensitive to light.
Side Effects of Wynzora
Common Side Effects
- Mild skin irritation, redness, or itching at the application site
- Dryness or peeling of the skin
Uncommon/Severe Side Effects
- Skin thinning or discoloration with prolonged use
- Increased risk of infections due to corticosteroid use
- Signs of allergic reactions, such as rash, swelling, or difficulty breathing
Risks and Warnings of Wynzora
- Skin Atrophy: Prolonged use of corticosteroids like betamethasone can cause skin thinning, stretch marks, and easy bruising, especially if used on sensitive areas of the skin.
- Systemic Absorption: If used over large areas of the body or for an extended period, Wynzora may be absorbed into the bloodstream, leading to potential systemic corticosteroid effects.
- Photosensitivity: Wynzora can increase sensitivity to sunlight, making it more likely for users to develop sunburn. Avoid excessive sun exposure and use sunscreen.
Interactions with Wynzora
Common Drug Interactions
- Other topical corticosteroids: Avoid using additional corticosteroids alongside Wynzora, as this may increase the risk of side effects such as skin thinning.
- Calcium supplements: High levels of calcium supplements may interact with the calcipotriene component and affect calcium metabolism.
Alternatives to Wynzora
- Taclonex (calcipotriene/betamethasone): Another topical treatment for plaque psoriasis.
- Dovonex (calcipotriene): A standalone vitamin D analog used to treat plaque psoriasis.
- Clobetasol (topical corticosteroid): A more potent corticosteroid used for severe plaque psoriasis.
- Tazarotene: A topical retinoid used to treat mild to moderate plaque psoriasis.
