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Vemlidy
Vemlidy (generic name: tenofovir alafenamide) is an antiviral medication used for the treatment of chronic hepatitis B virus (HBV) infection in adults and adolescents aged 12 years and older with compensated liver disease. Vemlidy helps reduce the amount of hepatitis B virus in the body, decreasing liver inflammation and slowing the progression of the disease. It belongs to a class of medications known as nucleotide reverse transcriptase inhibitors (NRTIs).
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Frequently Asked Questions
How long do I need to take Vemlidy?
Vemlidy is usually taken long-term to manage chronic hepatitis B infection. Your healthcare provider will monitor your liver function and viral load to determine the duration of treatment.
Is Vemlidy a cure for hepatitis B?
No, Vemlidy is not a cure for hepatitis B, but it helps manage the infection and prevents complications like liver damage, cirrhosis, and liver cancer.
What should I do if I miss a dose of Vemlidy?
If you miss a dose of Vemlidy, take it as soon as you remember, unless it is close to the time for your next dose. Do not take two doses at once to make up for a missed dose.
Can Vemlidy be used in patients with HIV?
Vemlidy is not recommended as a standalone treatment for patients with HIV. It can be used as part of a combination regimen in patients coinfected with HIV and hepatitis B.
Can I drink alcohol while taking Vemlidy?
It's best to avoid alcohol while taking Vemlidy, as alcohol can increase the risk of liver damage in patients with hepatitis B. Always discuss alcohol use with your healthcare provider.
Comprehensive Drug Guide
How Does Vemlidy Work?
Vemlidy works by inhibiting reverse transcriptase, an enzyme that the hepatitis B virus uses to replicate its genetic material. By blocking this enzyme, Vemlidy prevents the virus from multiplying and spreading throughout the body. This helps lower the viral load and reduce damage to the liver.
Common Dosages
- 25 mg oral tablets
Typical Dosing
- The typical dose of Vemlidy for adults and adolescents aged 12 years and older is 25 mg once daily, taken with food.
Typical Dosing
FDA Approved Indications
- Chronic hepatitis B virus (HBV) infection in adults and adolescents aged 12 years and older with compensated liver disease.
Who Shouldn't Take Vemlidy?
- Known hypersensitivity to tenofovir alafenamide or any of its components.
- Decompensated liver disease (such as patients with Child-Pugh Class B or C liver disease).
Advice From The Pharmacist
- Take Vemlidy once daily with food, as food improves its absorption and effectiveness. Do not miss doses, as this can lead to the virus becoming resistant to treatment.
- Regular monitoring: Your healthcare provider will regularly monitor your kidney function and liver health while on Vemlidy, as it can affect both.
- Vemlidy is not a cure for hepatitis B, but it helps manage the infection and prevent complications like liver damage, cirrhosis, and liver cancer.
- Do not stop taking Vemlidy suddenly: Doing so can cause the hepatitis B virus to rebound, leading to worsening liver disease.
Side Effects of Vemlidy
Common Side Effects
- Headache
- Fatigue
- Nausea
- Abdominal pain
Uncommon/Severe Side Effects
- Lactic acidosis (buildup of lactic acid in the blood), with symptoms like weakness, tiredness, or difficulty breathing.
- Liver problems (yellowing of the skin or eyes, dark urine).
- Kidney problems (changes in urine output, swelling in the legs or feet).
Risks and Warnings of Vemlidy
- Lactic Acidosis and Severe Hepatomegaly: Vemlidy can cause lactic acidosis and severe liver problems, particularly in patients with underlying liver disease. Contact your healthcare provider if you experience symptoms like unusual fatigue, muscle pain, or difficulty breathing.
- Hepatitis B Exacerbation: Discontinuing Vemlidy can lead to a flare-up of hepatitis B, which may result in severe liver damage. Do not stop taking Vemlidy without consulting your healthcare provider.
- Kidney Function: Vemlidy is processed by the kidneys, so patients with existing kidney problems should be closely monitored for changes in kidney function during treatment.
Interactions with Vemlidy
Common Drug Interactions
- Rifamycins (e.g., rifampin, rifabutin): These drugs can reduce the effectiveness of Vemlidy by increasing its metabolism.
- Anticonvulsants (e.g., carbamazepine, phenobarbital): These medications can reduce Vemlidy's blood levels, decreasing its efficacy.
- HIV Medications: If you are coinfected with HIV and hepatitis B, Vemlidy should be used as part of a combination regimen with HIV medications to prevent resistance.
Alternatives to Vemlidy
- Tenofovir disoproxil fumarate (TDF): Another form of tenofovir used for chronic hepatitis B, though it may have a higher risk of kidney and bone side effects compared to Vemlidy.
- Entecavir: An antiviral medication used to treat chronic hepatitis B infection.
- Lamivudine: Another NRTI used for the treatment of chronic hepatitis B, though resistance can develop over time.
