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Vascepa
Vascepa (generic name: icosapent ethyl) is a prescription medication derived from omega-3 fatty acids. It is used to lower high triglyceride levels in the blood and reduce the risk of cardiovascular events in certain patients. Vascepa is typically prescribed to patients with severe hypertriglyceridemia (triglyceride levels ≥ 500 mg/dL) or those with cardiovascular disease or diabetes and additional risk factors. It helps reduce triglyceride levels without raising LDL (bad) cholesterol, making it a beneficial treatment for heart health.
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Frequently Asked Questions
How long does it take for Vascepa to lower triglycerides?
Triglyceride levels may start to decrease within a few weeks, but significant reductions are typically seen after several months of consistent use.
Can Vascepa be taken with other cholesterol medications?
Yes, Vascepa can be taken alongside statins and other cholesterol-lowering medications. In fact, it is often prescribed in combination with statins for patients at high cardiovascular risk.
Does Vascepa contain fish oil?
Yes, Vascepa is derived from omega-3 fatty acids found in marine sources (fish oil). However, it is a purified form of icosapent ethyl.
Can Vascepa cause weight gain?
No, Vascepa does not typically cause weight gain. It is used to lower triglycerides and support heart health.
Is Vascepa safe to use long-term?
Yes, Vascepa is safe for long-term use when prescribed by a healthcare provider to manage triglycerides and reduce cardiovascular risk. Regular follow-up with your doctor is recommended to monitor its effectiveness and any potential side effects.
Comprehensive Drug Guide
How Does Vascepa Work?
Vascepa contains icosapent ethyl, an omega-3 fatty acid derivative, which works by reducing the production of triglycerides in the liver and increasing their clearance from the blood. It also has anti-inflammatory properties and helps reduce cardiovascular risk by stabilizing plaque in arteries and reducing oxidative stress and inflammation.
Common Dosages
- 1-gram capsules.
Typical Dosing
- For cardiovascular risk reduction: The typical dose is 2 grams twice daily (a total of 4 grams daily).
- For severe hypertriglyceridemia: The recommended dose is also 2 grams twice daily with food.
Typical Dosing
FDA Approved Indications
- Reduction of cardiovascular risk in patients with elevated triglycerides (≥ 150 mg/dL) and established cardiovascular disease or diabetes with additional risk factors.
- Treatment of severe hypertriglyceridemia (triglyceride levels ≥ 500 mg/dL) to reduce triglyceride levels.
Who Shouldn't Take Vascepa?
- Known hypersensitivity to icosapent ethyl or any component of the formulation.
- Fish or shellfish allergies, as Vascepa is derived from marine sources.
Advice From The Pharmacist
- Take Vascepa with food to enhance absorption and reduce the risk of gastrointestinal side effects.
- If you miss a dose, take it as soon as you remember, unless it is close to your next scheduled dose. Do not double up doses.
- Continue following a low-fat, heart-healthy diet while taking Vascepa to maximize the benefits of triglyceride and cardiovascular risk reduction.
- Store the capsules at room temperature and keep them in a dry place.
Side Effects of Vascepa
Common Side Effects
- Joint pain
- Sore throat
- Diarrhea
- Nasal congestion
Uncommon/Severe Side Effects
- Atrial fibrillation or flutter (irregular heartbeats)
- Bleeding: Vascepa may increase the risk of bleeding, especially in those on anticoagulants or blood thinners.
Risks and Warnings of Vascepa
- Bleeding Risk: Vascepa may increase the risk of bleeding, particularly in patients taking blood thinners such as warfarin or clopidogrel. Monitor for signs of bleeding, such as easy bruising or prolonged bleeding.
- Atrial Fibrillation/Flutter: Vascepa has been associated with an increased risk of atrial fibrillation (especially in patients with a history of the condition), which can increase the risk of stroke.
- Allergic Reactions: Since Vascepa is derived from marine sources, patients with a fish or shellfish allergy should avoid it.
Interactions with Vascepa
Common Drug Interactions
- Anticoagulants and antiplatelet drugs (e.g., warfarin, aspirin): Vascepa can increase the risk of bleeding when taken with blood-thinning medications.
- Cholesterol-lowering medications: Vascepa can be used alongside statins to enhance cardiovascular protection and triglyceride reduction, but close monitoring is recommended.
Alternatives to Vascepa
- Lovaza: Another prescription omega-3 fatty acid used to lower triglyceride levels, though it may raise LDL cholesterol, unlike Vascepa.
- Fibrates (e.g., fenofibrate): Medications used to lower triglycerides and improve cholesterol levels.
- Niacin: A B-vitamin used in high doses to reduce cholesterol and triglyceride levels, though it may have more side effects compared to Vascepa.
