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Vabysmo
Vabysmo (generic name: faricimab-svoa) is a biologic injectable medication used to treat certain retinal eye conditions, including neovascular (wet) age-related macular degeneration (AMD) and diabetic macular edema (DME). Vabysmo is a bispecific antibody that targets and inhibits two key pathways involved in abnormal blood vessel growth and leakage in the eye, helping to slow or reverse vision loss in these conditions.
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Frequently Asked Questions
How long does it take for Vabysmo to start working?
Most patients begin to see improvements in their vision or stabilization of their condition within the first few weeks of treatment. Full benefits may take longer, depending on the individual’s response to treatment.
How often do I need Vabysmo injections?
Initially, Vabysmo is administered every 4 weeks for the first four injections. After this, your ophthalmologist will assess your response and may extend the dosing interval to every 8 to 16 weeks.
Can Vabysmo cure wet AMD or DME?
Vabysmo does not cure these conditions, but it helps to slow the progression of vision loss and, in some cases, improve vision. Ongoing treatment may be necessary to maintain its effects.
Is Vabysmo painful?
The injection is administered under local anesthesia, so most patients experience minimal discomfort. Some may experience mild irritation or pressure during the injection, but this typically resolves quickly.
What should I do if I experience vision changes after my injection?
If you experience any sudden changes in vision, such as increased floaters, flashes of light, or vision loss, contact your eye doctor immediately, as these could be signs of complications like retinal detachment or infection.
Comprehensive Drug Guide
How Does Vabysmo Work?
Vabysmo is a bispecific antibody that inhibits both vascular endothelial growth factor-A (VEGF-A) and angiopoietin-2 (Ang-2). These proteins play a role in abnormal blood vessel growth and leakage in the retina, which leads to vision loss in conditions like AMD and DME. By blocking these pathways, Vabysmo helps reduce the formation of abnormal blood vessels and decrease fluid leakage, thereby preserving or improving vision.
Common Dosages
- Intravitreal injection (faricimab-svoa 6 mg/0.05 mL).
Typical Dosing
- The initial dosing for both wet AMD and DME is typically one injection every 4 weeks for the first 4 doses.
- After the initial phase, the dosing interval may be extended based on the patient's response, typically to every 8 to 16 weeks, as determined by the treating physician.
Typical Dosing
FDA Approved Indications
- Neovascular (wet) age-related macular degeneration (AMD).
- Diabetic macular edema (DME).
Who Shouldn't Take Vabysmo?
- Known hypersensitivity to faricimab or any component of the formulation.
- Ocular or periocular infections.
- Active intraocular inflammation.
Advice From The Pharmacist
- Vabysmo is administered as an intravitreal injection, meaning it is injected directly into the eye by a trained ophthalmologist. The procedure is performed under local anesthesia to minimize discomfort.
- After the injection, you may experience mild discomfort, redness, or sensitivity in the eye. These symptoms should resolve within a few days, but contact your doctor if they persist.
- Keep follow-up appointments as directed by your healthcare provider to ensure the treatment’s effectiveness and to monitor the health of your eye.
- Report any signs of infection, such as pain, swelling, or vision changes after the injection, as these may indicate a serious complication.
- Store and handle the medication as directed by your healthcare provider or pharmacist, though Vabysmo is typically handled in the clinic.
Side Effects of Vabysmo
Common Side Effects
- Mild eye irritation, redness, or pain at the injection site.
- Floaters or blurred vision.
- Increased sensitivity to light.
Uncommon/Severe Side Effects
- Endophthalmitis (a severe eye infection that can cause vision loss).
- Retinal detachment.
- Increased intraocular pressure.
Risks and Warnings of Vabysmo
- Endophthalmitis: One of the most serious risks of intravitreal injections is infection inside the eye, known as endophthalmitis. Symptoms include pain, redness, vision loss, or increased sensitivity to light. Seek immediate medical attention if these occur.
- Retinal Detachment: There is a risk of retinal detachment with intravitreal injections. If you experience sudden vision changes, flashes of light, or floaters, contact your eye doctor immediately.
- Increased Intraocular Pressure: Vabysmo may cause a temporary increase in intraocular pressure (eye pressure), so your eye doctor will monitor this during follow-up visits.
Interactions with Vabysmo
Common Drug Interactions
- There are no significant drug interactions associated with Vabysmo due to its localized administration into the eye. However, always inform your healthcare provider of any medications you are taking to ensure comprehensive care.
Alternatives to Vabysmo
- Eylea (aflibercept): Another biologic injection used to treat wet AMD and DME by inhibiting VEGF.
- Lucentis (ranibizumab): A biologic injection used to treat wet AMD, DME, and other retinal diseases by blocking VEGF.
- Beovu (brolucizumab): Another VEGF inhibitor used for treating wet AMD.
