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Eylea
Eylea (generic name: aflibercept) is an anti-VEGF (vascular endothelial growth factor) injection used to treat various retinal conditions that can lead to vision loss, including wet age-related macular degeneration (AMD) and diabetic macular edema (DME). By inhibiting VEGF, Eylea helps reduce abnormal blood vessel growth and leakage in the eye, preserving vision.
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Frequently Asked Questions
How long does it take for Eylea to work?
Improvements in vision may be seen after several weeks of treatment with Eylea, though results vary by individual.
How often do I need Eylea injections?
Injections are typically given every 4 to 8 weeks, depending on your condition and response to treatment.
Can Eylea cure wet AMD?
Eylea does not cure wet AMD, but it helps slow the progression of vision loss and may improve vision in some patients.
What should I do if I experience eye pain after the injection?
Mild discomfort is normal after Eylea injections, but severe pain or signs of infection (such as redness or discharge) should be reported to your ophthalmologist immediately.
Is Eylea covered by insurance?
Most insurance plans, including Medicare, cover Eylea for approved indications. Check with your provider for specific coverage details.
Comprehensive Drug Guide
How Does Eylea Work?
Eylea works by inhibiting VEGF, a protein that stimulates the growth of abnormal blood vessels in the retina. By blocking VEGF, Eylea prevents fluid buildup, bleeding, and scarring in the eye, which can lead to vision loss in conditions like wet AMD and DME.
Common Dosages
- 2 mg/0.05 mL intravitreal injection
Typical Dosing
- The typical dosing for Eylea in wet AMD is 2 mg every 4 weeks for the first 12 weeks, followed by 2 mg every 8 weeks.
- For diabetic macular edema, the dose is 2 mg every 4 weeks for the first 5 injections, then 2 mg every 8 weeks.
Typical Dosing
FDA Approved Indications
- Wet age-related macular degeneration (AMD)
- Diabetic macular edema (DME)
- Macular edema following retinal vein occlusion
- Diabetic retinopathy
Who Shouldn't Take Eylea?
- Ocular or periocular infections
- Active intraocular inflammation
Advice From The Pharmacist
- Eylea is administered by an ophthalmologist via intravitreal injection in a clinic setting.
- After the injection, you may experience temporary blurred vision or eye discomfort. Contact your doctor if you experience significant pain, vision changes, or signs of infection (such as redness, swelling, or discharge).
- Eylea can increase the risk of eye infections and increased intraocular pressure, so regular monitoring by your ophthalmologist is required.
Side Effects of Eylea
Common Side Effects
- Eye pain
- Blurred vision
- Eye redness
Uncommon/Severe Side Effects
- Retinal detachment
- Endophthalmitis (eye infection)
- Increased intraocular pressure
Risks and Warnings of Eylea
- Endophthalmitis: As an injection into the eye, Eylea carries a risk of eye infections (endophthalmitis). Report any symptoms such as pain, redness, or vision changes to your doctor immediately.
- Retinal Detachment: Rare cases of retinal detachment have been reported following Eylea injections. Monitor for flashes of light or new floaters in your vision.
Interactions with Eylea
Common Drug Interactions
- No significant drug interactions have been identified with Eylea.
Alternatives to Eylea
- Lucentis (ranibizumab): Another anti-VEGF therapy used to treat wet AMD and other retinal conditions.
- Avastin (bevacizumab): An off-label anti-VEGF therapy used for treating similar retinal conditions.
- Beovu (brolucizumab): Another anti-VEGF therapy for wet AMD.
