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Beovu
Beovu (brolucizumab-dbll) is a vascular endothelial growth factor (VEGF) inhibitor used to treat wet age-related macular degeneration (AMD). It works by reducing the growth of abnormal blood vessels in the eye and decreasing leakage from these vessels, which can lead to vision loss. Beovu helps slow the progression of wet AMD and maintain vision in affected patients.
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Frequently Asked Questions
How soon can I expect to see improvements with Beovu?
Some patients may begin to see improvements in their vision as early as one month after starting treatment with Beovu. However, individual results may vary.
Can I drive after receiving a Beovu injection?
You may experience blurred vision or eye discomfort after the injection. It’s advisable to have someone drive you home from your appointment.
How long will I need to take Beovu?
Beovu is typically administered on a long-term basis to control wet AMD. Your ophthalmologist will monitor your progress and adjust the dosing schedule as needed.
Is Beovu safe during pregnancy?
Beovu should be used during pregnancy only if clearly needed. Consult your doctor if you are pregnant or planning to become pregnant while using this medication.
What should I do if I miss a scheduled injection?
If you miss a scheduled dose, contact your ophthalmologist to reschedule the injection as soon as possible. Maintaining a regular treatment schedule is important for optimal results.
Comprehensive Drug Guide
How Does Beovu Work?
Beovu works by inhibiting VEGF-A, a protein responsible for the growth of abnormal blood vessels in the retina, which can lead to leakage, swelling, and vision loss in conditions like wet AMD. By blocking VEGF-A, Beovu helps reduce these abnormal blood vessels and prevent further vision deterioration.
Common Dosages
- Intravitreal injection: 6 mg/0.05 mL solution in a pre-filled syringe or vial.
Typical Dosing
- The typical dosing schedule starts with one injection every month for the first three months, followed by one injection every 8 to 12 weeks depending on the patient's response and doctor’s recommendation.
Typical Dosing
FDA Approved Indications
- Treatment of wet age-related macular degeneration (AMD)
Who Shouldn't Take Beovu?
- Ocular or periocular infections
- Active intraocular inflammation
- Known hypersensitivity to brolucizumab or any other components of the formulation
Advice From The Pharmacist
- Beovu is administered by an ophthalmologist directly into the vitreous cavity of the eye, under sterile conditions.
- You may experience temporary visual disturbances or discomfort after the injection, so arrange for someone to drive you home.
- Contact your doctor immediately if you experience sudden vision changes, eye pain, or redness after the injection, as these could indicate serious side effects.
Side Effects of Beovu
Common Side Effects
- Blurred vision
- Eye pain
- Floaters
- Increased intraocular pressure
Uncommon/Severe Side Effects
- Retinal artery occlusion
- Retinal detachment
- Endophthalmitis (eye infection)
- Inflammation inside the eye
Risks and Warnings of Beovu
- Endophthalmitis: There is a risk of serious infection following intravitreal injections. Signs include eye pain, redness, sensitivity to light, or changes in vision.
- Retinal detachment: Beovu can increase the risk of retinal detachment, leading to vision loss if not promptly treated.
- Arterial thromboembolic events: Beovu has been associated with a small risk of systemic arterial thromboembolic events, such as stroke or heart attack.
Interactions with Beovu
Common Drug Interactions
- There are no significant drug interactions reported with Beovu, as it is administered locally in the eye. However, you should inform your healthcare provider of all medications you are taking.
Alternatives to Beovu
- Eylea (aflibercept): Another anti-VEGF injection used to treat wet AMD and other retinal conditions.
- Lucentis (ranibizumab): A similar treatment for wet AMD, diabetic macular edema, and other retinal conditions.
- Avastin (bevacizumab): Off-label use for treating wet AMD, though originally developed as a cancer therapy.
