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Urocit-K 10
Urocit-K 10 (generic name: potassium citrate) is a potassium supplement used to prevent the formation of kidney stones and treat conditions associated with low urinary citrate levels. It is particularly effective in reducing the formation of calcium oxalate and uric acid stones. Urocit-K 10 works by increasing urinary citrate, which binds calcium and reduces the likelihood of stone formation, while also making the urine less acidic by raising its pH.
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Frequently Asked Questions
How long does it take for Urocit-K 10 to work?
Urocit-K 10 typically begins to increase urinary citrate levels and pH within a few days to weeks, but preventing kidney stones may take longer, depending on individual conditions.
Can Urocit-K 10 be taken long-term?
Yes, Urocit-K 10 can be used long-term under a healthcare provider's supervision. Long-term use requires regular monitoring of potassium levels, kidney function, and urinary pH.
What should I do if I miss a dose of Urocit-K 10?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Can Urocit-K 10 cause high potassium levels?
Yes, one of the main risks of Urocit-K 10 is hyperkalemia, especially in individuals with kidney impairment or those taking other medications that increase potassium levels.
Should I follow a special diet while taking Urocit-K 10?
Your healthcare provider may recommend dietary adjustments, such as increasing fluid intake and avoiding high-potassium foods, depending on your individual condition. Always follow your provider’s dietary advice while taking Urocit-K 10.
Comprehensive Drug Guide
How Does Urocit-K 10 Work?
Urocit-K 10 works by increasing urinary citrate levels and raising urinary pH. The citrate binds calcium, preventing the formation of calcium oxalate crystals. By alkalinizing the urine (increasing pH), it also reduces the risk of uric acid stones. This dual action makes Urocit-K 10 effective in preventing the formation of both calcium oxalate and uric acid kidney stones.
Common Dosages
- 10 mEq extended-release tablets.
Typical Dosing
- The typical dose is 15 to 30 mEq per day, divided into two or three doses.
- Doses are individualized based on the patient's urinary citrate levels, urinary pH, and overall response to treatment.
- The tablets should be swallowed whole—they should not be crushed, chewed, or broken to maintain the extended-release effect.
Typical Dosing
FDA Approved Indications
- Prevention of calcium oxalate kidney stones in patients with low urinary citrate (hypocitraturia).
- Prevention of uric acid kidney stones.
- Treatment of renal tubular acidosis with calcium stones.
Who Shouldn't Take Urocit-K 10?
- Hyperkalemia (high potassium levels in the blood).
- Chronic kidney disease or any condition that impairs potassium excretion.
- Dehydration, untreated Addison's disease, or acute renal failure.
- Gastrointestinal obstructions or any condition causing delayed gastric emptying.
Advice From The Pharmacist
- ake Urocit-K 10 with meals and a full glass of water to reduce the risk of gastrointestinal irritation.
- Do not crush, chew, or break the extended-release tablets, as doing so can cause a rapid release of potassium, which increases the risk of side effects.
- Your healthcare provider will monitor your potassium levels and urinary pH to ensure the medication is effective and safe for you.
- Store Urocit-K 10 at room temperature and keep it away from moisture and heat.
Side Effects of Urocit-K 10
Common Side Effects
- Nausea or upset stomach
- Diarrhea or loose stools
- Mild abdominal discomfort or bloating
Uncommon/Severe Side Effects
- Hyperkalemia (high potassium levels), which can cause symptoms such as muscle weakness, irregular heartbeat, or numbness.
- Gastrointestinal irritation or ulcers, particularly if the tablets are crushed or chewed.
- Allergic reactions (rash, itching, swelling, difficulty breathing).
Risks and Warnings of Urocit-K 10
- Hyperkalemia: Urocit-K 10 can cause high potassium levels, leading to heart rhythm problems and muscle weakness. This is especially concerning for individuals with kidney problems or those taking medications that increase potassium levels (such as ACE inhibitors or potassium-sparing diuretics).
- Gastrointestinal Risk: Extended-release potassium formulations can irritate the gastrointestinal tract and may lead to ulcers if the tablets are not swallowed whole. Ensure that tablets are taken with food and water.
- Kidney Monitoring: Individuals with kidney impairment require careful monitoring to avoid complications like hyperkalemia.
Interactions with Urocit-K 10
Common Drug Interactions
- Potassium-sparing diuretics (e.g., spironolactone, amiloride): Using these drugs with Urocit-K 10 increases the risk of hyperkalemia.
- ACE inhibitors or ARBs (e.g., lisinopril, losartan): These medications can also increase potassium levels, raising the risk of hyperkalemia.
- Nonsteroidal anti-inflammatory drugs (NSAIDs): These drugs may reduce kidney function, increasing the risk of potassium buildup when combined with Urocit-K 10.
Alternatives to Urocit-K 10
- Generic potassium citrate: Provides the same active ingredient as Urocit-K and is available in different strengths.
- Sodium bicarbonate: Used to alkalinize urine, though it does not provide the citrate benefits of potassium citrate.
- Thiazide diuretics: Sometimes used in combination with potassium citrate to reduce calcium excretion in the urine and prevent kidney stones.
