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Uceris
Uceris (generic name: budesonide) is a prescription corticosteroid medication used to treat ulcerative colitis. It works by reducing inflammation in the colon, helping to manage flare-ups and promote remission in patients with mild to moderate ulcerative colitis. Unlike some other corticosteroids, Uceris is formulated to release its active ingredient specifically in the colon, minimizing systemic side effects.
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Frequently Asked Questions
How long does it take for Uceris to work?
Patients typically begin to notice an improvement in symptoms within 2 to 4 weeks, though full benefits may take longer.
Can Uceris be used long-term?
Uceris is generally prescribed for short-term use (up to 8 weeks) to induce remission in ulcerative colitis. Long-term use increases the risk of corticosteroid-related side effects, and your healthcare provider may transition you to other maintenance medications.
Can I take Uceris with food?
Yes, Uceris can be taken with or without food. If you experience stomach upset, taking it with food may help.
Can I drink alcohol while taking Uceris?
It is advisable to limit or avoid alcohol while taking Uceris, as alcohol can exacerbate certain side effects, such as stomach irritation.
What should I do if I miss a dose of Uceris?
If you miss a dose of Uceris, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.
Comprehensive Drug Guide
How Does Uceris Work?
Uceris contains budesonide, which is a potent anti-inflammatory steroid. It works by suppressing the body’s immune response to inflammation in the colon. Budesonide targets inflammatory pathways, helping to reduce symptoms like diarrhea, abdominal pain, and rectal bleeding in patients with ulcerative colitis. Its extended-release formulation allows for targeted delivery of the drug to the colon.
Common Dosages
- Oral extended-release tablets: 9 mg once daily in the morning.
- Rectal foam: One actuation (2 mg) twice daily for 2 weeks, then once daily for another 4 weeks.
Typical Dosing
- Oral tablets: Take one 9 mg tablet once daily in the morning, with or without food. Swallow the tablet whole—do not crush or chew it.
- Rectal foam: Administer one actuation twice daily for the first 2 weeks, followed by once daily for the next 4 weeks, as directed by your healthcare provider.
Typical Dosing
FDA Approved Indications
- Induction of remission in patients with mild to moderate ulcerative colitis.
Who Shouldn't Take Uceris?
- Known hypersensitivity to budesonide or any other ingredients in the formulation.
- Systemic fungal infections.
Advice From The Pharmacist
- Take Uceris exactly as prescribed, and do not stop taking it abruptly unless instructed by your healthcare provider, as this can lead to withdrawal symptoms.
- Avoid consuming grapefruit or grapefruit juice, as it can increase the levels of budesonide in the blood, leading to a higher risk of side effects.
- If using the rectal foam, ensure you administer it correctly and consistently to achieve the best results. Follow your healthcare provider’s instructions carefully.
- Store Uceris at room temperature, away from moisture and heat.
Side Effects of Uceris
Common Side Effects
- Headache
- Nausea
- Stomach pain or gas
- Fatigue
- Back pain
Uncommon/Severe Side Effects
- Adrenal suppression (fatigue, weakness, weight loss)
- Cushing’s syndrome (weight gain, thinning skin, moon face)
- Increased risk of infection (due to immune suppression)
- Osteoporosis with long-term use
Risks and Warnings of Uceris
- Adrenal Suppression: Long-term use of Uceris, especially at higher doses, can lead to adrenal gland suppression, which may reduce the body’s ability to respond to stress. Do not stop using Uceris suddenly; tapering may be necessary.
- Immune System Suppression: Uceris suppresses the immune system, increasing the risk of infections. Avoid contact with people who have contagious illnesses, and inform your healthcare provider if you develop signs of infection.
- Systemic Corticosteroid Effects: While Uceris is designed to have localized effects in the colon, some patients may still experience systemic side effects, such as weight gain, fluid retention, or mood changes.
Interactions with Uceris
Common Drug Interactions
- Grapefruit or grapefruit juice: Increases the absorption of budesonide, potentially leading to increased side effects.
- CYP3A4 inhibitors: Drugs such as ketoconazole, itraconazole, and clarithromycin may increase budesonide levels in the blood and raise the risk of side effects.
- Immunosuppressive drugs: Caution is advised when using other immunosuppressants, as this could increase the risk of infection.
Alternatives to Uceris
- Mesalamine (Asacol, Lialda): A non-steroidal anti-inflammatory drug used to treat ulcerative colitis.
- Prednisone: A systemic corticosteroid used for more severe cases of inflammatory bowel disease.
- Biologics (e.g., Humira, Remicade): Advanced treatments for moderate to severe ulcerative colitis.
- Entocort EC: Another budesonide formulation used for Crohn’s disease affecting the ileum and ascending colon.
