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Mesalamine
Mesalamine is used to treat ulcerative colitis, a type of inflammatory bowel disease. It can serve as a chameleon by reducing inflammation in the body, thus alleviating symptoms like stomach pain, diarrhea, and rectal bleeding. Common potential side effects include headache, dizziness, minor stomach pain, or mild skin rash. But don't worry, the positives surely outweigh the negatives!
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Frequently Asked Questions
Can I take Mesalamine if I have kidney disease?
Mesalamine should be used with caution in patients with kidney disease as it can potentially have an impact on kidney function, especially on longterm use. Regular monitoring of kidney function is recommended if you have to use Mesalamine.
Can Mesalamine be taken during pregnancy?
Mesalamine can be used during pregnancy if the benefits to the mother outweigh the risks to the unborn child. It falls under the FDA pregnancy category B, indicating that it does not appear to harm the fetus in animal studies. However, the effects on the human fetus are not well studied.
Do I need to follow a special diet when taking Mesalamine?
No specific diet is recommended when taking Mesalamine, but it's always a good idea to maintain a wellbalanced and healthy diet.
Does Mesalamine affect liver function?
Yes, Mesalamine can occasionally affect the liver, causing changes to liver function tests and, on rare occasions, liver failure.
What should I do if I miss a dose of Mesalamine?
If it's close to the time of your next dose, skip the missed dose and continue with your regular dosing. Do NOT double your dose to make up for the missed one. If not close to your next dose, take the missed dose as soon as you remember.
Comprehensive Drug Guide
How Does Mesalamine Work?
Mesalamine is an aminosalicylate antiinflammatory drug. It works by inhibiting the production of inflammatory chemicals in the lining of the colon, helping to reduce inflammation and promoting healing.
What is Mesalamine Used For?
FDA indications: Mesalamine is primarily used to treat mild to moderate ulcerative colitis, and to prevent the symptoms of ulcerative colitis from recurring.
Offlabel uses: It's also been used, less commonly, to treat Crohn's disease.
Common Dosages
Tablets: 1.2g, 400mg, 800mg
Rectal suspension: 4g/60mL
Rectal suppositories: 500mg, 1000mg
Typical Dosing
FDA Approved Indications
- Ulcerative colitis: 0.8 to 4.8g per day orally in divided doses; 1 to 4g rectally once a day at bedtime.
- Maintenance of remission: 0.8 to 2.4g per day orally in divided doses.
Off-Label Uses
- Crohn's disease: 2 to 4g orally per day in divided doses.
Who Shouldn't Take Mesalamine?
- If you are allergic to mesalamine or any other component in the drug.
- Have kidney disease.
- Have liver impairment.
- Have a gastrointestinal obstruction.
- Have gastric retention.
- Have hypersensitivity to salicylates (like aspirin).
- Undergoing urinary tract surgery (as mesalamine may influence certain test results).
Advice From The Pharmacist
- Take mesalamine with or without food. If it upsets your stomach, try taking it with food.
- Also, it is best to swallow the tablets whole. Don?t crush or chew them.
- Hydrate well as Mesalamine can affect the kidneys; drinking plenty of fluids can be beneficial.
- Always get regular checkups to monitor kidney function.
- Avoid exposure to sunlight or tanning beds.
- Lastly, always remember to keep all your laboratory and doctor?s appointments for the regular monitoring of your condition.
Side Effects of Mesalamine
Common Side Effects
- Upset stomach, nausea, vomiting, and diarrhea.
- Headache.
- Rash.
- Changes in liver function tests.
Uncommon/Severe Side Effects
- Uncommon side effects:
- Pancreatitis.
- Hair loss.
- Photosensitivity.
- Rare side effects:
- Kidney inflammation.
- Pneumonia.
- Muscle pain, joint pain, or bone pain.
- Severe side effects:
- Chest pain or discomfort; fatigue; uneven heartbeat.
- Hemolytic anemia; jaundice; bloody diarrhea.
- Allergic reaction: difficulty breathing; swelling of your face, lips, tongue, or throat.
Risks and Warnings of Mesalamine
- Avoid taking Mesalamine if you have a known allergy to the drug or if you have kidney disease or gastrointestinal obstruction.
- The drug is known to affect kidney function, particularly with longterm use, so anyone with kidney disease or reduced kidney function should use this medication cautiously.
- Mesalamine can occasionally affect the liver. Those with liver disease or reduced liver function should use Mesalamine with caution.
- Those with peptic ulcer disease could see an exacerbation of symptoms and should discuss this with their doctor.
- Anyone due to undergo a urinary tract surgical procedure should mention their use of Mesalamine to their physician.
Interactions with Mesalamine
Common Drug Interactions
- Azathioprine
- Methotrexate
- Amoxicillin
- Warfarin
- Allopurinol
Alternatives to Mesalamine
- Sulfasalazine
- Balsalazide
- Olsalazine
- Prednisone
- Budesonide
- Azathioprine
