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Lialda
Lialda (mesalamine) is an anti-inflammatory medication primarily used for the treatment of ulcerative colitis and proctitis. It belongs to a class of drugs known as 5-aminosalicylic acid (5-ASA) derivatives, which work by reducing inflammation in the lining of the intestines.
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Frequently Asked Questions
How long does it take for Lialda to start working?
Patients may begin to notice improvements in symptoms within 2 to 4 weeks of starting Lialda.
Can I take Lialda with other medications?
Always consult your healthcare provider before combining Lialda with other medications to avoid potential interactions.
What should I do if I miss a dose of Lialda?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use Lialda during pregnancy?
Lialda should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can Lialda cause weight gain?
Weight gain is not commonly associated with Lialda. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Lialda Work?
Lialda works locally in the gastrointestinal tract by inhibiting the production of inflammatory mediators. It directly reduces inflammation in the colon by interfering with the function of leukotrienes and other inflammatory substances, helping to alleviate symptoms associated with ulcerative colitis.
Common Dosages
- Delayed-release tablets: Common dosages include 1.2 g and 2.4 g.
Typical Dosing
- The usual dosage for adults is 2.4 g per day, taken as two 1.2 g tablets once daily or as directed by a healthcare provider. Dosing may be adjusted based on the severity of the condition and individual patient response.
Typical Dosing
FDA Approved Indications
- Induction of remission in patients with active ulcerative colitis.
- Maintenance of remission in patients with ulcerative colitis.
Who Shouldn't Take Lialda?
- Known hypersensitivity to mesalamine or any components of the formulation
- Severe renal impairment
Advice From The Pharmacist
- Patients should be advised to take Lialda with plenty of water and to maintain hydration.
- Discuss the importance of adherence to the prescribed dosing regimen for optimal management of ulcerative colitis.
- Encourage patients to report any unusual symptoms, such as abdominal pain, fever, or rectal bleeding.
Side Effects of Lialda
Common Side Effects
- Nausea
- Diarrhea
- Abdominal pain
- Headache
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Kidney problems (e.g., nephrotoxicity)
- Blood disorders (e.g., thrombocytopenia)
Risks and Warnings of Lialda
- Kidney Monitoring: Regular monitoring of renal function is recommended, especially in patients with a history of kidney disease.
- Mesalamine Sensitivity: Patients with a history of hypersensitivity to mesalamine should be monitored closely for any signs of reaction.
Interactions with Lialda
Common Drug Interactions
- Other Gastrointestinal Medications: Caution is advised when used with other medications that may affect gut motility or inflammatory conditions.
- NSAIDs: Concurrent use with non-steroidal anti-inflammatory drugs may increase the risk of renal adverse effects.
Alternatives to Lialda
- Other 5-ASA Compounds: Such as sulfasalazine or olsalazine for managing ulcerative colitis.
- Corticosteroids: May be used for more severe inflammation if 5-ASA drugs are insufficient.
