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Tirosint
Tirosint (generic name: levothyroxine) is a thyroid hormone replacement medication used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. Tirosint helps restore normal thyroid hormone levels, improving symptoms such as fatigue, weight gain, and sensitivity to cold. Unlike other formulations of levothyroxine, Tirosint is available as a gel capsule or oral solution, making it an ideal option for patients with allergies to excipients or those who have trouble absorbing traditional tablet forms.
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Frequently Asked Questions
How long does it take for Tirosint to work?
It can take several weeks for Tirosint to start improving symptoms of hypothyroidism. Full effects may be seen after 6 to 8 weeks, with regular monitoring to ensure optimal dosing.
Can I switch from another form of levothyroxine to Tirosint?
Yes, switching is possible, but you may need dose adjustments. Tirosint’s absorption differs slightly from tablets, so always consult your healthcare provider when changing forms.
What should I do if I miss a dose of Tirosint?
Take the missed dose as soon as you remember, unless it is close to the time of your next dose. Do not double the dose to make up for a missed one.
Is Tirosint safe during pregnancy?
Yes, Tirosint is considered safe during pregnancy. Pregnant women with hypothyroidism often require higher doses to maintain normal thyroid levels.
Can Tirosint cause allergic reactions?
Tirosint is less likely to cause allergic reactions because it contains fewer excipients than other formulations. However, allergic reactions, while rare, are still possible.
Comprehensive Drug Guide
How Does Tirosint Work?
Tirosint contains levothyroxine, a synthetic form of the thyroid hormone T4. After absorption, Tirosint is converted into T3 (the active form of thyroid hormone) in the body, which regulates metabolism, energy production, and growth. By replacing the deficient hormone, Tirosint helps restore normal metabolic activity.
Common Dosages
- Oral soft-gel capsules: 13 mcg, 25 mcg, 50 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg, 137 mcg, 150 mcg, 175 mcg, 200 mcg, 300 mcg
- Oral solution: 25 mcg/mL, 50 mcg/mL, 100 mcg/mL
Typical Dosing
- For hypothyroidism: The typical starting dose for adults is 25 to 50 mcg daily, taken on an empty stomach, at least 30 minutes before breakfast. The dose is gradually increased based on the patient’s thyroid hormone levels, with typical maintenance doses ranging from 100 mcg to 200 mcg daily.
Typical Dosing
FDA Approved Indications
- Primary hypothyroidism due to various causes (such as Hashimoto’s thyroiditis)
- Pituitary hypothyroidism
- Congenital hypothyroidism
- Goiter prevention
- Thyroid cancer treatment (as part of thyroid hormone suppression therapy)
Who Shouldn't Take Tirosint?
- Untreated adrenal insufficiency
- Known hypersensitivity to levothyroxine or any of its components
- Thyrotoxicosis (overactive thyroid)
Advice From The Pharmacist
- Take Tirosint on an empty stomach, ideally 30 to 60 minutes before breakfast, for optimal absorption.
- Avoid taking calcium or iron supplements within 4 hours of Tirosint, as they can interfere with absorption.
- Tirosint’s gel capsules and oral solution have fewer excipients compared to other levothyroxine formulations, which may benefit patients with allergies or absorption issues.
- Monitor your thyroid levels regularly, and consult your healthcare provider for dose adjustments.
Side Effects of Tirosint
Common Side Effects
- Temporary hair loss
- Increased heart rate
- Anxiety or nervousness
- Weight loss
- Sweating
Uncommon/Severe Side Effects
- Heart palpitations or chest pain
- Shortness of breath
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Bone loss or fractures with long-term high-dose use
Risks and Warnings of Tirosint
- Overdose Risk: Taking too much Tirosint can cause symptoms of hyperthyroidism, including rapid heart rate, anxiety, and weight loss. Regular monitoring is essential to avoid overdose.
- Bone Density: High doses over extended periods can decrease bone density, especially in postmenopausal women.
- Cardiovascular Risk: Use caution in patients with heart disease, as Tirosint can increase the risk of heart complications if not properly dosed.
Interactions with Tirosint
Common Drug Interactions
- Calcium and iron supplements: These can reduce the absorption of Tirosint. It is recommended to take them at least 4 hours apart.
- Warfarin: Tirosint may enhance the effects of anticoagulants like warfarin, increasing the risk of bleeding.
- Antidiabetic medications: Tirosint can affect blood sugar levels, so diabetic patients may need adjustments in their diabetes medications.
Alternatives to Tirosint
- Synthroid (levothyroxine): A tablet form of levothyroxine used for the same indications as Tirosint.
- Levoxyl: Another brand of levothyroxine in tablet form.
- Armour Thyroid: A natural thyroid hormone derived from porcine thyroid glands, containing both T4 and T3.
- Liothyronine (Cytomel): A synthetic form of T3 used for hypothyroidism.
