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Tiglutik
Tiglutik (generic name: riluzole) is an oral suspension used to treat amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig’s disease. ALS is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord, leading to muscle weakness and eventually paralysis. Tiglutik works by reducing the release of glutamate, a neurotransmitter that is thought to play a role in nerve damage in ALS. Tiglutik is designed for patients who have difficulty swallowing tablets, offering a liquid formulation for easier administration.
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Frequently Asked Questions
How long does it take for Tiglutik to start working?
Tiglutik may take several weeks to show benefits, and the goal is to slow the progression of ALS. It is important to take the medication regularly to maintain its effectiveness.
Can I take Tiglutik with food?
No, Tiglutik should be taken on an empty stomach, at least 1 hour before or 2 hours after meals to ensure proper absorption.
How is Tiglutik stored?
Tiglutik should be stored in the refrigerator and used within 15 days after opening the bottle. Do not freeze the medication.
What should I do if I miss a dose of Tiglutik?
If you miss a dose, take it as soon as you remember. If it’s close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Will Tiglutik cure ALS?
No, Tiglutik does not cure ALS. It is designed to slow the progression of the disease and may help extend survival or delay the need for mechanical breathing support.
Comprehensive Drug Guide
How Does Tiglutik Work?
Tiglutik works by inhibiting the release of glutamate, a neurotransmitter that is believed to contribute to the nerve cell damage seen in ALS. By reducing glutamate activity, Tiglutik helps to slow the progression of ALS, although it does not cure the disease or reverse nerve damage.
Common Dosages
Tiglutik is available as an oral suspension, with a typical strength of 50 mg per 10 mL.
Typical Dosing
- For ALS: The usual dose is 50 mg (10 mL) taken orally every 12 hours, approximately 1 hour before or 2 hours after a meal. The dosing schedule is important for maintaining consistent blood levels of the medication.
Typical Dosing
FDA Approved Indications
- Amyotrophic lateral sclerosis (ALS), to help extend survival or delay the need for tracheostomy (artificial breathing support).
Who Shouldn't Take Tiglutik?
- Known hypersensitivity to riluzole or any of its components
- Severe liver impairment, as Tiglutik can increase liver enzyme levels
Advice From The Pharmacist
- Take Tiglutik on an empty stomach (at least 1 hour before or 2 hours after meals) to ensure proper absorption.
- Shake the bottle well before each use to ensure the medication is evenly distributed.
- Store Tiglutik in the refrigerator and use within 15 days after opening the bottle.
- Monitor liver function regularly, as Tiglutik can elevate liver enzymes, which may indicate liver damage.
- Inform your healthcare provider if you experience any signs of liver issues, such as yellowing of the skin or eyes, dark urine, or persistent nausea.
Side Effects of Tiglutik
Common Side Effects
- Nausea
- Fatigue
- Dizziness
- Decreased appetite
- Diarrhea
Uncommon/Severe Side Effects
- Liver toxicity (elevated liver enzymes)
- Lung disease (interstitial lung disease)
- Severe allergic reactions (swelling, rash, difficulty breathing)
Risks and Warnings of Tiglutik
- Liver Toxicity: Tiglutik can cause elevated liver enzymes, which may indicate liver damage. Regular blood tests are necessary to monitor liver function.
- Lung Disease: Although rare, Tiglutik has been associated with cases of interstitial lung disease. Patients who experience new or worsening respiratory symptoms should contact their doctor immediately.
- Neurological Effects: Dizziness and fatigue are common with Tiglutik use. Patients should be cautious when performing tasks that require full alertness, such as driving.
Interactions with Tiglutik
Common Drug Interactions
- CYP1A2 inhibitors: Medications such as ciprofloxacin and fluvoxamine can increase the blood levels of riluzole, increasing the risk of side effects.
- CYP1A2 inducers: Drugs like rifampin may reduce the effectiveness of Tiglutik by lowering riluzole levels.
- Alcohol: Combining Tiglutik with alcohol can increase the risk of liver damage. It is advised to limit or avoid alcohol use while on Tiglutik.
Alternatives to Tiglutik
- Rilutek (riluzole): A tablet formulation of riluzole, used for the same indication in ALS patients.
- Radicava (edaravone): An intravenous medication used to slow the progression of ALS, often used in combination with riluzole.
- Nuedexta: A medication used in ALS patients for the treatment of pseudobulbar affect (uncontrolled laughing or crying).
