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Rilutek
Rilutek (riluzole) is a prescription medication primarily used for the treatment of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. Rilutek is known to extend survival and time to tracheostomy in patients with ALS by reducing the release of glutamate, a neurotransmitter that, in excessive amounts, can lead to nerve cell damage.
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Frequently Asked Questions
How quickly does Rilutek start to work?
Rilutek may not provide immediate relief of symptoms. It is intended for long-term use to slow disease progression in ALS, with benefits often seen over several months.
Can I stop taking Rilutek suddenly?
It is important to consult your healthcare provider before stopping Rilutek, as sudden discontinuation can affect the management of ALS.
Are there any specific dietary restrictions while using Rilutek?
There are no specific dietary restrictions; however, maintaining a balanced diet may support overall health.
What should I do if I miss a dose of Rilutek?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Rilutek safe for long-term use?
Rilutek is generally safe for long-term use in patients with ALS under medical supervision, with regular monitoring for liver function and other potential side effects. Regular follow-up appointments are important to assess treatment effectiveness and manage any issues that arise.
Comprehensive Drug Guide
How Does Rilutek Work?
- Inhibiting the release of glutamate: It decreases the release of glutamate from nerve terminals, helping to protect nerve cells from glutamate toxicity.
- Modulating sodium channels: Riluzole may also affect sodium channels, contributing to its neuroprotective effects.
Common Dosages
- Tablets: Common strength is 50 mg.
Typical Dosing
- The usual recommended dose of Rilutek is 50 mg taken twice daily, with or without food. It is important to follow the healthcare provider's instructions regarding dosing.
Typical Dosing
FDA Approved Indications
- Treatment of amyotrophic lateral sclerosis (ALS) to extend survival and delay the need for tracheostomy.
Who Shouldn't Take Rilutek?
- Known hypersensitivity to riluzole or any components of the formulation.
- Severe liver impairment, as this may increase the risk of toxicity.
Advice From The Pharmacist
- Instruct patients to take Rilutek exactly as prescribed and to maintain consistent dosing intervals.
- Advise patients about potential side effects, including liver function changes, and the importance of regular monitoring of liver enzymes through blood tests.
- Discuss the need to report any signs of liver issues, such as jaundice, dark urine, or severe fatigue.
Side Effects of Rilutek
Common Side Effects
- Nausea
- Diarrhea
- Asthenia (weakness)
- Dizziness
- Liver enzyme elevation
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing)
- Hepatotoxicity (significant liver damage).
Risks and Warnings of Rilutek
- Liver Function: Regular liver function tests are recommended to monitor for potential hepatotoxicity, especially in patients with pre-existing liver conditions.
- Pregnancy and Breastfeeding: Rilutek should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. The safety of Rilutek during breastfeeding is not well established, so consult a healthcare provider for guidance.
Interactions with Rilutek
Common Drug Interactions
- Other Medications: Patients should inform their healthcare provider about all medications they are taking, particularly those that affect liver enzymes (such as certain anticonvulsants or antifungal medications), as these can interact with riluzole and affect its efficacy and safety.
Alternatives to Rilutek
- Other ALS Treatments: Alternatives may include edavarone (another FDA-approved treatment for ALS) or supportive therapies that focus on managing symptoms and improving quality of life.
