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tiaGABine HCl

Tiagabine HCl is a prescription anticonvulsant medication used to treat partial seizures in individuals with epilepsy. It works by increasing levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain, which helps reduce the occurrence of seizures. Tiagabine is often used in combination with other seizure medications for patients who do not achieve full control with a single medication.



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Frequently Asked Questions

How long does it take for Tiagabine HCl to start working?
Open FAQClose FAQ

It may take several weeks for tiagabine to reach its full effect in preventing seizures. Your doctor may adjust the dose gradually based on your response to the medication.

Can I drink alcohol while taking Tiagabine HCl?
Open FAQClose FAQ

No, it is advisable to avoid alcohol while taking tiagabine, as alcohol can increase the risk of drowsiness, dizziness, and seizures.

Can Tiagabine HCl cause memory problems?
Open FAQClose FAQ

Yes, Tiagabine may cause difficulty concentrating or memory problems in some patients. If you experience these side effects, inform your healthcare provider.

What should I do if I miss a dose of Tiagabine HCl?
Open FAQClose FAQ

If you miss a dose, take it as soon as you remember. If it’s close to the time of your next dose, skip the missed dose and take the next dose at the regular time. Do not double the dose.

Is Tiagabine HCl safe for long-term use?
Open FAQClose FAQ

Yes, tiagabine is generally safe for long-term use when taken as prescribed. However, regular monitoring by your healthcare provider is important to ensure its continued effectiveness and safety.

Comprehensive Drug Guide

How Does tiaGABine HCl Work?

Tiagabine works by inhibiting the reuptake of GABA, an inhibitory neurotransmitter in the central nervous system. By increasing GABA levels, tiagabine helps to stabilize neural activity and reduce the likelihood of seizure episodes.



Common Dosages

  • 2 mg
  • 4 mg
  • 12 mg
  • 16 mg

Typical Dosing

  • For partial seizures: The typical starting dose is 4 mg once or twice daily, with the dose gradually increased based on clinical response and tolerance. The maintenance dose is typically between 32 mg to 56 mg per day, divided into multiple doses.


Typical Dosing

FDA Approved Indications

  • Partial seizures in patients with epilepsy (used in combination with other anticonvulsants).


Who Shouldn't Take tiaGABine HCl?

  • Known hypersensitivity to tiagabine or any of its components
  • Severe liver disease, as the drug is metabolized in the liver and may accumulate in cases of liver impairment


Advice From The Pharmacist

  • Take Tiagabine HCl with food, as it improves absorption and helps reduce stomach upset.
  • Do not stop taking tiagabine suddenly, as this can cause an increase in seizure activity. Always follow your healthcare provider's instructions for tapering off the medication.
  • If you miss a dose, take it as soon as you remember, but if it’s close to your next dose, skip the missed dose. Do not double up doses.
  • Tiagabine can cause drowsiness or dizziness, so avoid driving or operating heavy machinery until you know how it affects you.


Side Effects of tiaGABine HCl

Common Side Effects

  • Dizziness
  • Drowsiness or fatigue
  • Nausea
  • Tremors
  • Difficulty concentrating


Uncommon/Severe Side Effects

  • Severe allergic reactions (rash, swelling, difficulty breathing)
  • Increased seizure frequency (especially if used in patients without epilepsy)
  • Confusion or hallucinations


Risks and Warnings of tiaGABine HCl

  • Increased Seizure Risk: Tiagabine may cause an increase in seizure activity in patients who do not have epilepsy. It should only be used in individuals diagnosed with epilepsy.
  • Cognitive Effects: Tiagabine can impair thinking, concentration, and coordination. Patients should be cautious when performing activities that require full alertness, such as driving.
  • Liver Impairment: Tiagabine is metabolized in the liver, so patients with liver impairment may require dose adjustments and regular monitoring of liver function.


Interactions with tiaGABine HCl

Common Drug Interactions

  • Other anticonvulsants: Tiagabine is often used in combination with other seizure medications. Your healthcare provider will monitor for interactions with other anticonvulsants, such as phenytoin, carbamazepine, or valproic acid.
  • CYP3A4 inducers: Medications that induce CYP3A4, such as rifampin or St. John's wort, can decrease the levels of tiagabine, potentially reducing its effectiveness.


Alternatives to tiaGABine HCl

  • Levetiracetam (Keppra): A commonly used anticonvulsant for partial and generalized seizures.
  • Lamotrigine (Lamictal): An anticonvulsant and mood stabilizer used for epilepsy and bipolar disorder.
  • Topiramate (Topamax): Another anticonvulsant used to treat epilepsy and prevent migraines.
  • Gabapentin (Neurontin): Used for partial seizures and neuropathic pain.