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Terconazole
Terconazole is a topical antifungal medication used to treat vaginal yeast infections caused by Candida albicans. It belongs to the azole class of antifungals and works by inhibiting the growth of fungi by disrupting the production of ergosterol, an essential component of fungal cell membranes. Terconazole is available in various formulations, including vaginal creams and suppositories, providing flexible options for patients dealing with yeast infections.
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Frequently Asked Questions
How long does it take for Terconazole to work?
Symptoms of a vaginal yeast infection may begin to improve within 3 days of starting treatment, though the full course of therapy should be completed (either 3 or 7 days) to ensure complete resolution of the infection.
Can I have sex while using Terconazole?
It is best to avoid sexual intercourse while using Terconazole, as the cream or suppository can weaken latex condoms and diaphragms, making them less effective. Additionally, sex may cause discomfort or prolong the healing process.
What should I do if I miss a dose of Terconazole?
If you miss a dose, apply it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I use tampons while using Terconazole?
No, it is recommended to avoid using tampons during treatment with Terconazole, as they can absorb the medication and reduce its effectiveness. Use sanitary pads instead if needed.
Is Terconazole safe to use during pregnancy?
Terconazole is classified as Category C for use during pregnancy, meaning its safety has not been fully established. Consult your doctor if you are pregnant or planning to become pregnant while considering this medication.
Comprehensive Drug Guide
How Does Terconazole Work?
Terconazole works by inhibiting ergosterol synthesis, a critical component of fungal cell membranes. Without ergosterol, fungal cells cannot maintain their structure, leading to cell death. This action makes Terconazole effective in treating vaginal yeast infections by stopping the growth of fungi that cause the infection.
Common Dosages
- Vaginal cream 0.4%: Applied once daily for 7 days.
- Vaginal cream 0.8%: Applied once daily for 3 days.
- Vaginal suppository 80 mg: Inserted once daily for 3 days.
Typical Dosing
- For yeast infections: The 0.4% cream is applied intravaginally once daily for 7 days, while the 0.8% cream or 80 mg suppository is used once daily for 3 days, depending on the severity of the infection.
Typical Dosing
FDA Approved Indications
- Vulvovaginal candidiasis (vaginal yeast infections) caused by Candida albicans.
Side Effects of Terconazole
Common Side Effects
- Mild vaginal burning or irritation
- Itching
- Vaginal discharge
- Headache
Uncommon/Severe Side Effects
- Severe allergic reactions, such as rash, swelling, or difficulty breathing
- Vaginal swelling or pain
Risks and Warnings of Terconazole
- Allergic Reactions: Though rare, some individuals may experience severe allergic reactions, including hives, swelling, or difficulty breathing. If these symptoms occur, discontinue use and seek medical attention immediately.
- Latex Product Interaction: Terconazole may weaken condoms and diaphragms. If using these products, consider alternative methods of contraception or abstain from intercourse during treatment.
- Consult Doctor if Symptoms Persist: If symptoms do not improve after completing the prescribed course of treatment, or if they worsen, consult your healthcare provider.
Interactions with Terconazole
Common Drug Interactions
- Latex products: As mentioned, Terconazole may reduce the effectiveness of latex or rubber products (such as condoms and diaphragms). Avoid using such products during treatment and for at least 3 days after the last dose.
- No significant drug interactions: Terconazole is a topical treatment with minimal systemic absorption, meaning it is unlikely to interact with most other medications.
Alternatives to Terconazole
- Miconazole (Monistat): Another antifungal cream used to treat vaginal yeast infections, available over-the-counter.
- Clotrimazole (Gyne-Lotrimin): An antifungal available in similar formulations for the treatment of vaginal yeast infections.
- Fluconazole (Diflucan): An oral antifungal used for vaginal yeast infections, taken as a single dose.
- Tioconazole (Vagistat): Another over-the-counter antifungal used to treat vaginal yeast infections.
