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Taztia XT
Taztia XT (generic name: diltiazem hydrochloride) is a calcium channel blocker used to treat hypertension (high blood pressure) and chronic stable angina (chest pain). It helps to relax blood vessels and reduce the workload on the heart, thereby lowering blood pressure and improving blood flow. By reducing the heart’s demand for oxygen, it also helps prevent angina (chest pain) episodes. Taztia XT is an extended-release form of diltiazem, which allows for once-daily dosing.
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Frequently Asked Questions
How long does it take for Taztia XT to work?
Taztia XT may take a few hours to start lowering blood pressure, but it can take 1 to 2 weeks for the full effect to be seen. For angina, improvement may be noticeable after a few days.
Can I drink grapefruit juice while taking Taztia XT?
No, grapefruit juice can increase the levels of diltiazem in your blood, which may lead to increased side effects like low blood pressure or bradycardia.
What should I do if I miss a dose of Taztia XT?
If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Can I stop taking Taztia XT if I feel better?
No, you should not stop taking Taztia XT suddenly. Abruptly discontinuing the medication can worsen angina or cause a spike in blood pressure. Talk to your doctor if you want to stop the medication.
Is Taztia XT safe to use during pregnancy?
Taztia XT is generally not recommended during pregnancy unless absolutely necessary, as there are potential risks to the fetus. Consult your healthcare provider if you are pregnant or planning to become pregnant while taking this medication.
Comprehensive Drug Guide
How Does Taztia XT Work?
Taztia XT works by blocking calcium channels in the muscle cells of the heart and blood vessels, which reduces the contraction of the heart muscles and dilates the arteries. This helps to lower blood pressure and decrease the workload on the heart. It also improves blood flow to the heart and prevents spasms of the coronary arteries, which can lead to angina.
Common Dosages
- 120 mg, 180 mg, 240 mg, 300 mg, and 360 mg extended-release capsules.
Typical Dosing
- For hypertension: The usual starting dose is 180 mg or 240 mg once daily, with doses adjusted based on the patient’s response. The maximum dose is 540 mg once daily.
- For chronic stable angina: The typical dose is 120 mg to 360 mg once daily, based on individual needs.
Typical Dosing
FDA Approved Indications
- Hypertension (to lower blood pressure)
- Chronic stable angina (chest pain)
Who Shouldn't Take Taztia XT?
- Severe hypotension (low blood pressure)
- Sick sinus syndrome or second- or third-degree AV block (unless a pacemaker is in place)
- Acute myocardial infarction with pulmonary congestion
- Known hypersensitivity to diltiazem or any component of the formulation
Advice From The Pharmacist
- Take Taztia XT once daily, preferably at the same time each day, with or without food.
- Do not crush or chew the capsules, as they are extended-release and meant to be slowly absorbed by the body over time.
- Monitor your blood pressure regularly while taking Taztia XT, especially if you are on other blood pressure medications.
- Avoid grapefruit and grapefruit juice while taking Taztia XT, as they can increase diltiazem levels in the blood and lead to increased side effects.
- Do not stop taking Taztia XT suddenly, as this can worsen your condition. Talk to your doctor about tapering off the medication if needed.
Side Effects of Taztia XT
Common Side Effects
- Dizziness or lightheadedness
- Headache
- Fatigue
- Nausea
- Bradycardia (slow heart rate)
- Edema (swelling, particularly in the legs and ankles)
Uncommon/Severe Side Effects
- Severe hypotension (very low blood pressure)
- Heart block or worsening of heart failure
- Liver enzyme elevations or liver damage
- Allergic reactions, including rash, itching, swelling, or difficulty breathing
Risks and Warnings of Taztia XT
- Bradycardia and Heart Block: Taztia XT can cause slowing of the heart rate (bradycardia) or block electrical signals in the heart, leading to heart block. Patients with existing heart conditions should be monitored closely, especially when starting treatment.
- Hypotension: Taztia XT may cause a significant drop in blood pressure, especially when used in combination with other blood pressure-lowering medications. Monitoring blood pressure is essential to avoid hypotension.
- Heart Failure: Use caution in patients with heart failure or compromised ventricular function, as diltiazem can exacerbate heart failure.
- Liver Toxicity: In rare cases, Taztia XT can cause liver enzyme elevations or liver damage. Regular liver function tests may be necessary in long-term use.
Interactions with Taztia XT
Common Drug Interactions
- Beta-blockers: When taken with beta-blockers (e.g., metoprolol), Taztia XT can increase the risk of bradycardia and heart block.
- CYP3A4 inhibitors: Drugs such as ketoconazole and ritonavir can increase diltiazem levels, leading to enhanced side effects.
- CYP3A4 inducers: Drugs such as rifampin and phenytoin can decrease diltiazem levels, reducing its effectiveness.
- Statins: Diltiazem can increase blood levels of statins such as simvastatin and lovastatin, increasing the risk of muscle toxicity (myopathy).
Alternatives to Taztia XT
- Amlodipine (Norvasc): Another calcium channel blocker used to treat high blood pressure and angina.
- Verapamil (Calan, Verelan): A non-dihydropyridine calcium channel blocker similar to diltiazem.
- Lisinopril (Prinivil, Zestril): An ACE inhibitor used to treat high blood pressure.
- Metoprolol (Lopressor, Toprol XL): A beta-blocker used for hypertension and angina.
- Losartan (Cozaar): An angiotensin receptor blocker (ARB) used for hypertension.
