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Tavalisse
Tavalisse (generic name: fostamatinib disodium hexahydrate) is an oral medication used to treat chronic immune thrombocytopenia (ITP) in adults. ITP is a condition where the immune system attacks and destroys platelets, which are necessary for normal blood clotting. Tavalisse works by inhibiting spleen tyrosine kinase (SYK), which is involved in the immune system’s destruction of platelets.
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Frequently Asked Questions
How long does it take for Tavalisse to work?
Platelet counts typically begin to increase after 1 to 2 weeks of treatment with Tavalisse, but it may take up to 12 weeks to see the full effect.
Can I stop taking Tavalisse once my platelet count improves?
No, it is important to continue taking Tavalisse as prescribed by your healthcare provider, even after your platelet count improves, unless advised to stop by your healthcare provider.
What should I do if I miss a dose?
If you miss a dose of Tavalisse, take it as soon as you remember unless it is close to the time of your next dose. Do not double up on doses to make up for a missed one.
Can Tavalisse be used during pregnancy?
The safety of Tavalisse during pregnancy has not been established. It is recommended to avoid Tavalisse during pregnancy unless the potential benefit justifies the potential risk to the fetus.
What should I do if I experience severe side effects while taking Tavalisse?
If you experience severe side effects, such as difficulty breathing, severe diarrhea, or signs of liver issues (e.g., yellowing of the skin or eyes), contact your healthcare provider immediately.
Comprehensive Drug Guide
How Does Tavalisse Work?
Tavalisse works by inhibiting spleen tyrosine kinase (SYK), an enzyme involved in platelet destruction in ITP. By blocking SYK, Tavalisse helps prevent the immune system from attacking and destroying platelets, thus increasing platelet counts in patients with chronic ITP.
Common Dosages
- 100 mg tablets
- 150 mg tablets
Typical Dosing
- The recommended starting dose is 100 mg taken orally twice daily. The dose may be increased to 150 mg twice daily based on platelet response and patient tolerance.
Typical Dosing
FDA Approved Indications
- Treatment of chronic immune thrombocytopenia (ITP) in adults who have had an inadequate response to other treatments.
Who Shouldn't Take Tavalisse?
- Known hypersensitivity to fostamatinib or any of the excipients in the medication.
Advice From The Pharmacist
- Take Tavalisse with or without food as prescribed by your healthcare provider.
- Monitor platelet counts regularly, as Tavalisse’s effectiveness is measured by changes in platelet levels.
- Watch for signs of bleeding (unexplained bruising, blood in stools or urine), as ITP can increase the risk of bleeding complications.
- Avoid grapefruit and grapefruit juice while taking Tavalisse, as they may interfere with the metabolism of the medication and increase the risk of side effects.
Side Effects of Tavalisse
Common Side Effects
- Diarrhea
- Hypertension (high blood pressure)
- Nausea
- Respiratory infections
- Dizziness
Uncommon/Severe Side Effects
- Liver toxicity: Elevated liver enzymes, which may require dose adjustments or discontinuation.
- Hypertension: Tavalisse can cause or worsen high blood pressure. Blood pressure should be monitored regularly.
- Neutropenia: A decrease in white blood cells, increasing the risk of infections.
Risks and Warnings of Tavalisse
- Liver Function: Tavalisse can cause increases in liver enzymes, which should be monitored regularly. Dose adjustments may be required if significant elevations are detected.
- Hypertension: Tavalisse may cause elevated blood pressure. Blood pressure should be checked regularly, and antihypertensive medications may be necessary for management.
- Diarrhea: Severe diarrhea can occur, which may require dose adjustments or treatment with antidiarrheal medications.
- Neutropenia: Decreased neutrophil counts can increase the risk of infections. Patients should be monitored for signs of infection, and complete blood counts (CBCs) should be performed regularly.
Interactions with Tavalisse
Common Drug Interactions
- Grapefruit: Can interfere with the metabolism of fostamatinib and increase the risk of side effects. Avoid grapefruit and grapefruit juice while on Tavalisse.
- CYP3A4 inhibitors: Drugs that inhibit CYP3A4 (such as ketoconazole) can increase fostamatinib levels and the risk of adverse effects.
- CYP3A4 inducers: Drugs that induce CYP3A4 (such as rifampin) can decrease fostamatinib levels, reducing its effectiveness.
Alternatives to Tavalisse
- Eltrombopag (Promacta): A thrombopoietin receptor agonist used to treat chronic ITP.
- Romiplostim (Nplate): Another thrombopoietin receptor agonist that stimulates platelet production in patients with ITP.
- Rituximab: A monoclonal antibody used in refractory cases of ITP.
