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Tarka
Tarka, a combination of trandolapril and verapamil hydrochloride, is used for the treatment of high blood pressure (hypertension). Trandolapril, an ACE inhibitor, helps relax blood vessels by blocking the enzyme that causes them to constrict. Verapamil, a calcium channel blocker, works by relaxing the muscles of the heart and blood vessels. Together, these two components help reduce blood pressure and prevent complications such as heart attacks and strokes. Tarka is effective in managing hypertension and improving cardiovascular health.
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Frequently Asked Questions
Can I take Tarka if I’m pregnant?
Tarka is not recommended during pregnancy, especially in the second and third trimesters, as it can harm the developing fetus. If you become pregnant while taking this medication, contact your healthcare provider immediately.
What should I do if I miss a dose?
If you miss a dose of Tarka, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for the missed one.
Can I drink alcohol while taking Tarka?
It’s advisable to limit alcohol consumption while taking Tarka, as it can increase the risk of dizziness and lower blood pressure.
How long will it take for Tarka to lower my blood pressure?
Tarka may start to lower your blood pressure within a few hours, but it may take a few weeks to see the full effect. It’s important to take it consistently as prescribed by your healthcare provider.
Are there any foods I should avoid while taking Tarka?
Avoid grapefruit and grapefruit juice, as they can interact with the medication and affect how it works in your body.
Comprehensive Drug Guide
How Does Tarka Work?
Tarka works by combining two mechanisms: Trandolapril relaxes blood vessels, making it easier for the heart to pump blood, while Verapamil slows down the heart rate and relaxes blood vessels. Together, these actions lower blood pressure and reduce the strain on the heart.
What is Tarka Used For?
Hypertension
Common Dosages
Tarka is available in tablet form with the following common dosage strengths:
- 1 mg/240 mg (Trandolapril 1 mg and Verapamil 240 mg)
- 2 mg/180 mg (Trandolapril 2 mg and Verapamil 180 mg)
- 2 mg/240 mg (Trandolapril 2 mg and Verapamil 240 mg)
- 4 mg/240 mg (Trandolapril 4 mg and Verapamil 240 mg)
For adults, the typical starting dose of Tarka is one tablet of the 1 mg/240 mg formulation taken once daily, usually in the morning. Depending on the patient's response to the medication, the dosage may be adjusted, with a maximum recommended dose of 4 mg/240 mg per day. This medication is not typically used in children.
Typical Dosing
Who Shouldn't Take Tarka?
Tarka should not be used in patients with a history of hypersensitivity to either trandolapril or verapamil. It is also contraindicated in individuals with severe left ventricular dysfunction, hypotension (systolic blood pressure <90 mm Hg), or a history of angioedema related to previous ACE inhibitor therapy. Additionally, it should not be used in patients with significant aortic stenosis or those who are pregnant.
Advice From The Pharmacist
When taking Tarka, it's important to take it at the same time each day, preferably in the morning. Swallow the tablet whole without crushing or chewing it. Avoid consuming grapefruit or grapefruit juice, as it can interfere with how the medication works. If you experience dizziness or lightheadedness, especially when getting up from a sitting or lying position, make sure to contact your healthcare provider. Additionally, regular blood pressure monitoring is recommended while on Tarka to ensure the medication is working effectively.
Side Effects of Tarka
Common Side Effects
Common side effects of Tarka include dizziness, fatigue, and cough. More serious side effects may include swelling (especially in the face, lips, or throat), shortness of breath, and signs of liver problems such as yellowing of the skin or eyes. If any severe side effects occur, seek medical attention immediately.
Risks and Warnings of Tarka
Major risks associated with Tarka include the potential for developing angioedema, a serious allergic reaction that can be life-threatening. This drug also carries a risk of hypotension, especially in patients with heart failure or those taking diuretics. It's important to inform your healthcare provider if you are pregnant, planning to become pregnant, or have kidney or liver problems before starting this medication.
Interactions with Tarka
Common Drug Interactions
Tarka can interact with several medications, including beta-blockers, diuretics, and lithium. Grapefruit juice can increase the levels of verapamil in the blood, potentially leading to adverse effects. Avoid combining this drug with alcohol, as it can enhance the blood pressure-lowering effects and increase the risk of side effects. Patients with a known allergy to ACE inhibitors should avoid taking Tarka.
Alternatives to Tarka
Alternative medications to Tarka include other combinations of antihypertensive agents such as lisinopril/hydrochlorothiazide, amlodipine/benazepril, or valsartan/hydrochlorothiazide. If trandolapril or verapamil cannot be tolerated, monotherapy with either an ACE inhibitor or calcium channel blocker may also be considered.
