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Tadliq
Tadliq (generic name: tadalafil) is an oral phosphodiesterase 5 (PDE5) inhibitor used to treat pulmonary arterial hypertension (PAH) in adults. It helps to improve the ability to exercise and slows down the progression of the disease by relaxing blood vessels in the lungs, allowing blood to flow more easily. Tadliq is available as an oral suspension, making it a suitable option for patients who may have difficulty swallowing tablets.
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Frequently Asked Questions
How long does it take for Tadliq to work?
Tadliq begins working within 30 minutes to 2 hours, but its full effects on improving exercise capacity in pulmonary arterial hypertension may take several weeks to be noticeable.
Can I take Tadliq with food?
Yes, Tadliq can be taken with or without food. However, it is important to take it at the same time each day to maintain consistent drug levels.
What should I do if I miss a dose?
If you miss a dose of Tadliq, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to make up for a missed one.
Can I drink alcohol while taking Tadliq?
Excessive alcohol consumption can increase the risk of side effects such as dizziness or low blood pressure. It is best to limit alcohol intake while taking Tadliq.
Is Tadliq safe to use during pregnancy?
Tadliq is generally not recommended during pregnancy, as its effects on pregnant women and the fetus are not well studied. Consult your healthcare provider if you are pregnant or planning to become pregnant.
Comprehensive Drug Guide
How Does Tadliq Work?
Tadalafil works by inhibiting phosphodiesterase type 5 (PDE5), an enzyme that breaks down cyclic guanosine monophosphate (cGMP). By blocking PDE5, tadalafil increases the levels of cGMP, which causes the relaxation of smooth muscles in the blood vessels, particularly in the lungs. This leads to vasodilation and a reduction in blood pressure within the lungs, improving exercise capacity in patients with pulmonary arterial hypertension.
What is Tadliq Used For?
Common Dosages
- 20 mg of tadalafil per 5 mL
Typical Dosing
- The typical dose for treating pulmonary arterial hypertension in adults is 40 mg (10 mL) once daily, taken at the same time each day. The dose should not be split over the day, and it should be taken consistently with or without food.
Typical Dosing
FDA Approved Indications
- Pulmonary arterial hypertension (PAH) to improve exercise ability in adults.
Off-Label Uses
Who Shouldn't Take Tadliq?
- Concurrent use of nitrates (such as nitroglycerin), as this can lead to severe drops in blood pressure.
- Severe liver or kidney impairment.
- Hypersensitivity to tadalafil or any component of the formulation.
Advice From The Pharmacist
- Shake the bottle well before each use to ensure the medication is properly mixed.
- Measure the dose carefully using the provided oral dosing syringe. Do not use a household spoon to measure the dose.
- Take Tadliq at the same time each day, with or without food, to maintain consistent blood levels.
- Avoid grapefruit juice while taking Tadliq, as it can increase the levels of tadalafil in your blood and lead to side effects.
- Do not take Tadliq with nitrates or alpha-blockers, as this combination can cause dangerous drops in blood pressure.
Side Effects of Tadliq
Common Side Effects
- Headache
- Flushing
- Indigestion
- Nasal congestion
- Back pain
- Muscle pain
Uncommon/Severe Side Effects
- Sudden vision loss (a rare condition known as non-arteritic anterior ischemic optic neuropathy, or NAION).
- Sudden hearing loss or ringing in the ears.
- Severe hypotension, especially when used with nitrates or certain blood pressure medications.
- Priapism (prolonged and painful erection lasting more than 4 hours).
Risks and Warnings of Tadliq
- Hypotension: Tadliq can cause a dangerous drop in blood pressure when used with nitrates (such as nitroglycerin) or alpha-blockers. Patients should avoid the use of these medications while on Tadliq.
- Vision Loss: Rare cases of vision loss have been reported with tadalafil use, particularly in patients with underlying risk factors such as diabetes or heart disease.
- Hearing Loss: Some patients have experienced sudden hearing loss while taking tadalafil. If this occurs, discontinue use and seek medical attention immediately.
- Priapism: A rare side effect of tadalafil is priapism, which is a prolonged and painful erection lasting more than 4 hours. If this occurs, seek immediate medical attention to prevent permanent damage.
Interactions with Tadliq
Common Drug Interactions
- Nitrates: The use of tadalafil with nitrates (e.g., nitroglycerin) is contraindicated due to the risk of severe hypotension.
- Alpha-blockers: Caution is advised when using Tadliq with alpha-blockers, as both drugs lower blood pressure and may lead to symptomatic hypotension.
- Antihypertensives: Tadalafil can enhance the blood pressure-lowering effects of antihypertensive medications.
- Grapefruit juice: Can increase the blood levels of tadalafil, leading to enhanced side effects.
Alternatives to Tadliq
- Adcirca (Tadalafil): Another brand of tadalafil used to treat pulmonary arterial hypertension.
- Sildenafil (Revatio): A PDE5 inhibitor used to treat pulmonary arterial hypertension.
- Bosentan (Tracleer): An endothelin receptor antagonist used to treat pulmonary arterial hypertension.
- Riociguat (Adempas): A soluble guanylate cyclase stimulator used for pulmonary arterial hypertension.