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Symjepi
Symjepi (generic name: epinephrine injection) is a prescription medication used to treat emergency situations of severe allergic reactions, known as anaphylaxis. It works by narrowing blood vessels and opening airways in the lungs, helping to reverse symptoms like difficulty breathing, swelling, low blood pressure, and hives. Symjepi is typically used for people who are at risk of severe allergic reactions due to foods, insect stings, medications, or other triggers. Unlike some other epinephrine injectors, Symjepi is available as a pre-filled syringe, designed to provide a quick, accurate dose of epinephrine during an emergency.
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Frequently Asked Questions
How quickly does Symjepi work?
Symjepi works within minutes of injection, providing rapid relief from symptoms of anaphylaxis, such as difficulty breathing, swelling, and low blood pressure.
Can Symjepi be used more than once?
Yes, Symjepi can be used more than once if symptoms persist or return, but it is critical to seek emergency medical care immediately after the first injection. A second injection can be administered 5 to 15 minutes after the first, if needed.
How should I store Symjepi?
Symjepi should be stored at room temperature and kept out of direct light. Avoid refrigerating or freezing it, as this can affect its effectiveness.
Is Symjepi safe for children?
Yes, Symjepi comes in a 0.15 mg dose for children weighing between 15 and 30 kg. Always follow your doctor’s guidance for the correct dose based on your child’s weight.
Can I use Symjepi for non-allergic causes of anaphylaxis?
Yes, Symjepi is used for all types of anaphylaxis, including those triggered by exercise, insect stings, medications, or unknown causes.
Comprehensive Drug Guide
How Does Symjepi Work?
- Vasoconstriction (narrowing of blood vessels), which helps raise blood pressure and reduce swelling.
- Bronchodilation (opening of the airways), making it easier to breathe.
- Reduction in the release of allergy-causing substances, such as histamines, from mast cells. This helps alleviate symptoms of anaphylaxis like itching, hives, and swelling.
Common Dosages
- 0.3 mg pre-filled syringe for adults and children weighing 30 kg (66 lbs) or more
- 0.15 mg pre-filled syringe for children weighing 15 to 30 kg (33 to 66 lbs)
Typical Dosing
- The typical dose for adults and children over 30 kg is 0.3 mg, injected into the muscle of the outer thigh during the first signs of anaphylaxis.
- For children weighing 15 to 30 kg, the dose is 0.15 mg, injected in the same manner.
Symjepi can be repeated every 5 to 15 minutes if symptoms persist or return, while waiting for emergency medical assistance.
Typical Dosing
FDA Approved Indications
- Anaphylaxis (severe allergic reactions) caused by allergens like food, insect stings, or medications
- Exercise-induced anaphylaxis
It is intended for immediate use during an allergic emergency until further medical help can be provided.
Who Shouldn't Take Symjepi?
- Known hypersensitivity to epinephrine or any component of the formulation (though the benefits of treatment in an emergency outweigh the risk).
- Pre-existing heart conditions, such as arrhythmias or severe hypertension, which may be worsened by epinephrine.
Advice From The Pharmacist
- Symjepi should always be carried by individuals at risk of anaphylaxis. It is important to ensure that you know how to use the pre-filled syringe properly.
- Train family members, friends, or caregivers on how to administer Symjepi in case you are unable to do so during an emergency.
- After using Symjepi, seek emergency medical care immediately, even if symptoms seem to improve, as a second wave of anaphylaxis can occur.
- Store Symjepi at room temperature and protect it from light. Do not refrigerate or freeze the medication.
- Regularly check the expiration date of Symjepi and replace it as needed to ensure effectiveness in an emergency.
Side Effects of Symjepi
Common Side Effects
- Tremors or shakiness
- Anxiety or nervousness
- Sweating
- Dizziness
- Headache
Uncommon/Severe Side Effects
- Chest pain or discomfort (due to heart effects)
- Severe headache
- Difficulty breathing or worsening shortness of breath (in some individuals with underlying respiratory conditions)
- High blood pressure (hypertension)
Risks and Warnings of Symjepi
- Cardiovascular Risk: Epinephrine can increase heart rate and blood pressure, potentially causing or worsening heart arrhythmias, especially in individuals with existing heart conditions.
- Rebound Anaphylaxis: Symptoms of anaphylaxis may return after initial treatment with Symjepi. It is crucial to seek emergency medical care after using the injection, even if symptoms improve.
- Injection Site Reactions: Symjepi should only be injected into the outer thigh. Accidental injection into areas like the hand or feet can cause local tissue damage due to constriction of blood vessels in those areas.
Interactions with Symjepi
Common Drug Interactions
- Beta-blockers: These medications can reduce the effectiveness of epinephrine, making it harder to reverse the effects of anaphylaxis.
- Antidepressants (e.g., MAO inhibitors, tricyclics): These drugs can increase the effects of epinephrine, leading to an increased risk of cardiovascular side effects, such as high blood pressure or arrhythmias.
- Digoxin or other heart medications: Use of epinephrine with heart medications can increase the risk of abnormal heart rhythms.
Alternatives to Symjepi
- EpiPen (epinephrine auto-injector): Another form of epinephrine used for the treatment of anaphylaxis, with an auto-injector mechanism for ease of use.
- Auvi-Q (epinephrine auto-injector): A compact epinephrine auto-injector with voice instructions to guide the user through the injection process.
- Adrenaclick (epinephrine auto-injector): Another epinephrine auto-injector that provides emergency treatment for anaphylaxis.
