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Auvi-Q
Auvi-Q is an epinephrine auto-injector used for the emergency treatment of severe allergic reactions (anaphylaxis) in individuals who are at risk for or have a history of these reactions. Anaphylaxis is a life-threatening allergic reaction that can occur rapidly after exposure to an allergen, such as certain foods, insect stings, medications, or latex. Auvi-Q contains a pre-measured dose of epinephrine, a medication that works quickly to reverse the severe symptoms of anaphylaxis by constricting blood vessels, opening airways, and reducing swelling.
Auvi-Q is unique because it is a compact, portable device that provides voice instructions to guide the user through the injection process, making it easier to use in emergency situations.
Drug Availability and Controlled Substance Status
Auvi-Q is available by prescription only and is not classified as a controlled substance. It is available in different dosages, typically prescribed based on the patient's weight, and is supplied in a single-use auto-injector.
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Frequently Asked Questions
How quickly does Auvi-Q work?
Auvi-Q starts working within minutes after injection, rapidly reversing the symptoms of anaphylaxis. It is important to use the auto-injector at the first sign of a severe allergic reaction and seek immediate medical attention.
Can I use Auvi-Q more than once?
Each Auvi-Q auto-injector delivers a single dose of epinephrine. If symptoms persist or return, a second dose may be administered with a new auto-injector after 5 to 15 minutes. However, you should seek emergency medical care immediately after using Auvi-Q, even if symptoms improve.
What should I do if I accidentally inject Auvi-Q into my hand or another area?
Accidental injection into areas other than the thigh can cause serious complications, such as reduced blood flow to the affected area. If this occurs, seek immediate medical attention. Always aim to inject Auvi-Q into the outer thigh, as recommended.
Is Auvi-Q safe for children?
Yes, Auvi-Q is available in pediatric doses (0.1 mg and 0.15 mg) and is safe for children when used as directed. Parents and caregivers should be trained on how to use the device properly.
Do I still need to go to the hospital after using Auvi-Q?
Yes, even if symptoms improve after using Auvi-Q, it is critical to seek emergency medical care. Anaphylaxis can have a biphasic course, where symptoms return after an initial improvement, requiring further treatment.
Comprehensive Drug Guide
How Does Auvi-Q Work?
Epinephrine, the active ingredient in Auvi-Q, works by stimulating alpha and beta-adrenergic receptors:
- Alpha-adrenergic effects: Cause vasoconstriction, which increases blood pressure and reduces the swelling of the airways and mucous membranes.
- Beta-adrenergic effects: Increase heart rate, relax bronchial smooth muscles to open the airways, and reduce the release of additional allergic mediators from mast cells.
These combined actions help to quickly reverse the symptoms of anaphylaxis, such as difficulty breathing, hives, swelling, and low blood pressure.
What is Auvi-Q Used For?
Common Dosages
Auvi-Q is available in different dosages based on the patient’s weight:
- 0.15 mg: For pediatric patients weighing 15 to 30 kg (33 to 66 lbs).
- 0.3 mg: For adults and children weighing 30 kg (66 lbs) or more.
- 0.1 mg: For infants and toddlers weighing 7.5 to 15 kg (16.5 to 33 lbs).
Each auto-injector delivers a single dose of epinephrine.
Typical Dosing
- Administration: Auvi-Q is injected intramuscularly into the anterolateral aspect of the thigh (outer thigh). It can be injected through clothing if necessary. The device provides voice instructions to guide the user through the process, making it easier to use in an emergency.
- Repeat Dosing: If symptoms persist or return, a second dose may be administered after 5 to 15 minutes using a new auto-injector. Patients should seek immediate medical attention after using Auvi-Q, even if symptoms appear to improve.
Typical Dosing
FDA Approved Indications
Auvi-Q is FDA-approved for:
- Emergency Treatment of Anaphylaxis: Including allergic reactions to foods, insect stings, medications, latex, and other allergens.
People with a History of Anaphylaxis: As a precautionary measure for those at risk of future anaphylactic reactions.
Who Shouldn't Take Auvi-Q?
Auvi-Q has no absolute contraindications in the setting of anaphylaxis, as the benefits of using epinephrine far outweigh any potential risks. However, caution is advised in patients with certain pre-existing conditions, such as heart disease, where the effects of epinephrine might pose additional risks.
Advice From The Pharmacist
Patients prescribed Auvi-Q should be advised to:
- Familiarize themselves with the device before an emergency occurs. Practice with a trainer device if available.
- Carry Auvi-Q with them at all times, as anaphylaxis can occur without warning.
- Understand the signs and symptoms of anaphylaxis and use Auvi-Q immediately if they suspect they are experiencing a severe allergic reaction.
- Seek immediate medical attention after using Auvi-Q, even if symptoms improve, as further medical treatment may be necessary.
- Store Auvi-Q at room temperature and protect it from light. Do not refrigerate or expose the device to extreme heat.
Side Effects of Auvi-Q
Common Side Effects
Common side effects of Auvi-Q may include:
- Rapid heartbeat (tachycardia)
- Palpitations
- Anxiety or nervousness
- Sweating
- Nausea or vomiting
- Dizziness or lightheadedness
- Headache
Uncommon/Severe Side Effects
Serious side effects, though rare, can include:
- Chest pain or pressure, particularly in patients with heart conditions.
- High blood pressure (hypertension).
- Arrhythmias: Abnormal heart rhythms, especially in individuals with a history of cardiac arrhythmias.
Patients should seek medical attention if they experience severe side effects after using Auvi-Q.
Risks and Warnings of Auvi-Q
- Cardiovascular Effects: Epinephrine can cause significant increases in heart rate and blood pressure, which may be risky for patients with underlying heart conditions. However, in the setting of anaphylaxis, these risks are generally outweighed by the need to treat the life-threatening reaction.
- Handling and Storage: Auvi-Q should be stored in its original case at room temperature and protected from light. It should not be refrigerated or exposed to extreme temperatures, as this can degrade the medication.
Interactions with Auvi-Q
Common Drug Interactions
There are no significant drug interactions with Auvi-Q in the emergency treatment of anaphylaxis. However, patients taking certain medications, such as beta-blockers, may have a reduced response to epinephrine. These patients should discuss their specific situation with their healthcare provider.
Alternatives to Auvi-Q
Alternative emergency treatments for anaphylaxis include:
- EpiPen: Another brand of epinephrine auto-injector that delivers the same medication but in a different device.
- Generic Epinephrine Auto-Injectors: Functionally similar to Auvi-Q and EpiPen, available in various designs.
The choice of device often depends on patient preference, ease of use, and insurance coverage.
