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Stalevo 200
Stalevo 200 is a combination medication used to treat Parkinson’s disease, a progressive neurological disorder that affects movement. It contains three active ingredients: levodopa, carbidopa, and entacapone. Levodopa is converted to dopamine in the brain, which helps improve muscle control and reduce the symptoms of Parkinson’s disease, such as tremors, stiffness, and slowness of movement. Carbidopa prevents levodopa from breaking down before it reaches the brain, and entacapone prolongs the effect of levodopa by inhibiting the COMT enzyme (catechol-O-methyltransferase), which breaks down dopamine.
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Frequently Asked Questions
How long does it take for Stalevo 200 to start working?
Stalevo 200 usually starts working within 30 minutes to an hour after taking a dose. The exact timing may vary depending on individual response.
Can I stop taking Stalevo 200 if I feel better?
No, do not stop taking Stalevo 200 suddenly, as this can cause serious withdrawal symptoms, including neuroleptic malignant syndrome (NMS). Always consult your doctor before making any changes to your medication regimen.
What should I do if I miss a dose of Stalevo 200?
If you miss a dose, take it as soon as you remember unless it’s close to the time for your next dose. Do not double up on doses to make up for a missed one.
Can Stalevo 200 be taken with other Parkinson’s medications?
Yes, Stalevo 200 can be used in combination with other Parkinson’s medications, such as dopamine agonists or MAO-B inhibitors, depending on the patient’s needs. Your healthcare provider will determine the best combination for you.
Can I drive while taking Stalevo 200?
Stalevo 200 can cause dizziness, drowsiness, or sudden sleep episodes. It is important to monitor how the medication affects you before engaging in activities like driving or operating heavy machinery. Consult your doctor if you experience significant drowsiness.
Comprehensive Drug Guide
How Does Stalevo 200 Work?
- Levodopa: A precursor of dopamine that crosses the blood-brain barrier and is converted into dopamine, which is deficient in Parkinson’s disease.
- Carbidopa: Prevents the peripheral breakdown of levodopa, ensuring more levodopa reaches the brain.
- Entacapone: Inhibits the COMT enzyme, which breaks down levodopa and dopamine, thus prolonging the effects of levodopa.
Together, these actions help to increase dopamine levels in the brain, improving motor function and alleviating symptoms of Parkinson’s disease.
Common Dosages
- 200 mg of levodopa
- 50 mg of carbidopa
- 200 mg of entacapone
Typical Dosing
- Stalevo 200 is taken up to 8 times a day, depending on the patient’s needs and response to treatment. It should be taken at the same time each day with or without food, although it is often recommended to take it with food to reduce gastrointestinal discomfort.
- The exact dosing schedule is personalized, depending on how well the patient responds to the medication and their stage of Parkinson’s disease.
Typical Dosing
FDA Approved Indications
- Parkinson’s disease in patients experiencing “wearing-off” symptoms, where the effects of levodopa diminish between doses.
Who Shouldn't Take Stalevo 200?
- Narrow-angle glaucoma
- Severe liver disease
- Hypersensitivity to levodopa, carbidopa, entacapone, or any of the other ingredients.
- History of neuroleptic malignant syndrome (NMS) or rhabdomyolysis.
Advice From The Pharmacist
- Take Stalevo 200 exactly as prescribed. It is important to maintain a regular dosing schedule to manage symptoms effectively.
- Do not stop taking Stalevo 200 abruptly, as this can lead to serious side effects, including neuroleptic malignant syndrome (NMS).
- If you experience nausea, taking the medication with food may help. However, avoid high-protein meals, as they can interfere with the absorption of levodopa.
- You may notice a change in the color of your urine, sweat, or saliva to a dark color. This is a harmless side effect but can stain clothing.
Side Effects of Stalevo 200
Common Side Effects
- Nausea
- Dizziness
- Diarrhea
- Fatigue
- Dark-colored urine or saliva
- Muscle cramps or stiffness
Uncommon/Severe Side Effects
- Neuroleptic malignant syndrome (NMS): Symptoms include fever, muscle rigidity, and confusion.
- Dyskinesia: Involuntary, uncontrolled movements, which may worsen over time.
- Hallucinations or confusion, particularly in elderly patients.
- Increased risk of compulsive behaviors, such as gambling or excessive eating.
Risks and Warnings of Stalevo 200
- Neuroleptic Malignant Syndrome (NMS): Abruptly stopping or rapidly reducing the dose of Stalevo 200 can lead to this life-threatening condition. It is important to taper off the medication gradually under medical supervision.
- Compulsive Behaviors: Some patients may develop compulsive behaviors, such as gambling or binge eating, while taking Stalevo 200. Inform your doctor if you notice changes in behavior.
- Dyskinesia: Long-term use of Stalevo 200 may lead to or worsen involuntary movements, particularly in patients with advanced Parkinson’s disease.
Interactions with Stalevo 200
Common Drug Interactions
- MAO inhibitors: Stalevo 200 should not be taken with non-selective monoamine oxidase inhibitors (such as phenelzine or tranylcypromine), as this can lead to high blood pressure.
- Antihypertensive medications: Combining Stalevo 200 with medications that lower blood pressure can increase the risk of low blood pressure and dizziness.
- Iron supplements: Iron can interfere with the absorption of levodopa, so it is best to separate the doses by at least 2 hours.
Alternatives to Stalevo 200
- Sinemet (levodopa/carbidopa): A combination of levodopa and carbidopa without the addition of entacapone.
- Comtan (entacapone): Used alongside levodopa/carbidopa to enhance its effects by prolonging dopamine availability.
- Rytary: An extended-release formulation of levodopa/carbidopa that provides smoother symptom control.
- Requip (ropinirole): A dopamine agonist that may be used alone or in combination with levodopa/carbidopa.
