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Entacapone
Entacapone belongs to a drug class known as catecholOmethyltransferase (COMT) inhibitors. It is used in synergy with other medications (levodopa/carbidopa) to treat symptoms associated with Parkinson's disease such as stiffness, tremors, muscle spasms, and poor muscle control.
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Frequently Asked Questions
Can I stop taking Entacapone?
No, you should not abruptly stop taking entacapone. Consult with your doctor about the safest way to discontinue the medication.
How does Entacapone work with my other Parkinson?s drugs?
Entacapone extends the benefits of levodopa/carbidopa by blocking an enzyme responsible for breaking down levodopa
What should I do if I miss a dose?
Take the missed dose as soon as you remember. If it?s nearing your next dose, skip it and stay on your schedule. Don?t double doses.
Will Entacapone change the color of my body fluids?
Yes, entacapone can darken the color of your sweat, saliva, and urine.
Comprehensive Drug Guide
How Does Entacapone Work?
Entacapone blocks the COMT enzyme, which usually metabolizes levodopa before it crosses the bloodbrain barrier. By doing this, more levodopa can enter the brain and exert its therapeutic effects, decreasing Parkinsonism's symptoms.
What is Entacapone Used For?
FDA indications: Entacapone is used to treat Parkinson's disease symptoms in patients already taking levodopa and carbidopa.
Common Dosages
Tablets: 200mg
Typical Dosing
FDA Approved Indications
- For FDAapproved indications:
- Parkinson's Disease: One 200mg tablet with each dose of levodopa/carbidopa, up to a maximum of 8 tablets per day(1600mg)
Who Shouldn't Take Entacapone?
- With liver diseases, as it may worsen your condition
- With an allergy to entacapone or any of its ingredients
- Pregnant people or those planning to get pregnant should consult a healthcare provider before taking this medication, as it may affect the unborn baby.
- Lactating mothers, as it is not known whether entacapone gets into breast milk.
Advice From The Pharmacist
- Take entacapone exactly as your doctor advises, and do not take more or less of it or take it more often than prescribed.
- Entacapone can be taken with or without food, but taking it with food may prevent stomach upset.
- Remember to take your regular dose of levodopa/carbidopa along with entacapone.
- Always stay in contact with your doctor and let them know about changes in symptoms or side effects.
- Never suddenly stop taking the medication as it may cause adverse effects.
Side Effects of Entacapone
Common Side Effects
- Common side effects:
- You might experience diarrhea, nausea, or abdominal pain.
- You might encounter dizziness or tiredness.
- You might have increased sweating.
- Severe side effects:
- Severe allergic reactions such as rash, itching, severe dizziness, or difficulty breathing necessitate immediate medical attention.
Risks and Warnings of Entacapone
- Entacapone has been associated with certain risks and may cause an increase in a liver enzyme called alanine aminotransferase (ALT). If you have liver disease, consult your doctor before taking this drug.
- It may cause or exacerbate dyskinesia, so a dosage adjustment of levodopa/carbidopa may be necessary.
- The use of entacapone can darken the color of your sweat, saliva, and urine (a harmless side effect).
Interactions with Entacapone
Common Drug Interactions
- MAO inhibitors
- Tricyclic antidepressants
- Antipsychotics
- Dopamine antagonists
- Isoproterenol
- Adrenaline
Alternatives to Entacapone
- Tolcapone
- Selegiline
- Rasagiline
- Amantadine
- Bromocriptine
- Pramipexole
