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Spritam
Spritam (generic name: levetiracetam) is a prescription medication used to treat epilepsy by helping to control partial-onset seizures, myoclonic seizures, and generalized tonic-clonic seizures. It belongs to a class of drugs known as anticonvulsants and works by stabilizing electrical activity in the brain. Spritam is unique in that it is the first 3D-printed medication, formulated as a rapidly dissolving tablet for oral disintegration, which makes it easy to take without needing water. This is especially helpful for individuals who have difficulty swallowing tablets.
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Frequently Asked Questions
How long does it take for Spritam to start working?
Spritam typically starts working within a few days of starting the medication, but it may take a few weeks to achieve the full therapeutic effect in controlling seizures.
Can I take Spritam with other seizure medications?
Yes, Spritam is often used in combination with other seizure medications. However, always consult your doctor before combining it with other drugs to avoid potential interactions.
Can I stop taking Spritam once my seizures are under control?
No, you should not stop taking Spritam abruptly, even if your seizures are controlled. Stopping the medication suddenly can increase the risk of seizures. Always consult your doctor before making any changes to your medication.
Is Spritam safe for children?
Yes, Spritam is approved for use in children as young as 4 years old for partial-onset seizures and for older children with other seizure types. The dosing for children is based on their weight.
What should I do if I miss a dose of Spritam?
If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. Do not double the dose to make up for the missed one.
Comprehensive Drug Guide
How Does Spritam Work?
Spritam’s exact mechanism of action is not fully understood, but it is believed to work by affecting the transmission of nerve signals in the brain, stabilizing electrical activity to prevent seizures. Levetiracetam modulates neurotransmitter release and has an impact on synaptic vesicle protein 2A, which may be involved in seizure control.
Common Dosages
- 250 mg, 500 mg, 750 mg, and 1000 mg oral disintegrating tablets.
The dosing depends on the patient's condition, weight, and medical history.
Typical Dosing
- For partial-onset seizures (patients 16 years and older): The typical starting dose is 500 mg twice daily, with an increase to 1000 mg twice daily depending on response and tolerability. The maximum recommended daily dose is 3000 mg.
- For myoclonic seizures (patients 12 years and older): The initial dose is 500 mg twice daily, with dose adjustments based on response. The maximum daily dose is 3000 mg.
- For generalized tonic-clonic seizures (patients 6 years and older): The starting dose is 500 mg twice daily, with gradual increases to a maximum daily dose of 3000 mg.
Spritam can be taken with or without food. It is designed to disintegrate quickly on the tongue, so there is no need for water.
Typical Dosing
FDA Approved Indications
- Partial-onset seizures in patients 4 years of age and older with epilepsy.
- Myoclonic seizures in patients 12 years and older with juvenile myoclonic epilepsy.
- Generalized tonic-clonic seizures in patients 6 years and older with idiopathic generalized epilepsy.
Who Shouldn't Take Spritam?
- Hypersensitivity or allergic reaction to levetiracetam or any component of the formulation.
Advice From The Pharmacist
- Spritam is an orally disintegrating tablet designed to dissolve quickly on the tongue. Take it as directed by your healthcare provider, and there is no need for water. Just place the tablet on your tongue and let it dissolve.
- Take Spritam at the same time each day to maintain consistent levels in your bloodstream.
- Do not stop taking Spritam abruptly, as this could increase the risk of seizures. Always consult your doctor before adjusting or stopping the medication.
- Common side effects may include drowsiness, dizziness, or fatigue. Avoid activities that require alertness, such as driving, until you know how the medication affects you.
- Store Spritam in a cool, dry place, away from moisture and heat.
Side Effects of Spritam
Common Side Effects
- Drowsiness
- Dizziness
- Fatigue
- Irritability
- Headache
Uncommon/Severe Side Effects
- Severe mood or behavior changes, including suicidal thoughts
- Stevens-Johnson syndrome (a rare but serious skin reaction)
- Allergic reactions, including rash, itching, or swelling
Risks and Warnings of Spritam
- Behavioral Changes: Spritam can cause mood swings, agitation, or suicidal thoughts, especially in younger patients. Patients should be closely monitored for any unusual changes in behavior or mood.
- Drowsiness and Dizziness: As Spritam can cause drowsiness, patients should avoid activities requiring full alertness (e.g., driving) until they know how the medication affects them.
- Withdrawal: Stopping Spritam suddenly can cause an increase in seizure frequency. Always taper off the medication under the guidance of a healthcare provider.
Interactions with Spritam
Common Drug Interactions
- CNS depressants: Combining Spritam with other central nervous system (CNS) depressants, such as benzodiazepines, opioids, or alcohol, can increase the risk of drowsiness and dizziness.
- Other anticonvulsants: Spritam may be used in combination with other seizure medications, but dose adjustments may be required to prevent interactions or additive side effects.
Alternatives to Spritam
- Keppra (levetiracetam): The traditional form of levetiracetam used to treat similar seizure disorders, available as tablets or an oral solution.
- Lamictal (lamotrigine): An anticonvulsant used for epilepsy and bipolar disorder.
- Depakote (valproic acid): A broad-spectrum anticonvulsant used for epilepsy, migraines, and bipolar disorder.
- Topamax (topiramate): Another anticonvulsant that can be used for epilepsy and migraine prevention.
