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Renagel
Renagel (sevelamer hydrochloride) is a phosphate binder used primarily to control hyperphosphatemia (elevated phosphate levels) in patients with chronic kidney disease (CKD) who are on dialysis. It helps to reduce serum phosphate levels by binding dietary phosphate in the gastrointestinal tract, preventing its absorption into the bloodstream.
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Frequently Asked Questions
How quickly does Renagel work?
Renagel typically starts to lower serum phosphate levels within a few days to weeks of consistent use, but individual responses may vary.
Can I stop taking Renagel suddenly?
It is generally not advisable to stop taking Renagel abruptly without consulting your healthcare provider, as this can lead to increased serum phosphate levels.
Are there any specific dietary restrictions while taking Renagel?
Patients should follow a diet low in phosphate and should discuss dietary restrictions with their healthcare provider or a dietitian.
What should I do if I miss a dose of Renagel?
If you miss a dose, take it with your next meal. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Renagel safe for long-term use?
Renagel is generally considered safe for long-term use under medical supervision, especially in patients with chronic kidney disease. Regular monitoring of phosphate levels and gastrointestinal health is essential.
Comprehensive Drug Guide
How Does Renagel Work?
Sevelamer works by binding phosphate in the intestines, forming an insoluble complex that is excreted in the feces. By reducing the absorption of dietary phosphate, it helps to maintain appropriate serum phosphate levels, which is crucial in managing patients with CKD and preventing complications such as bone disease.
What is Renagel Used For?
Common Dosages
- Tablets: 800 mg.
Typical Dosing
- The usual starting dose for adults is 800 to 1600 mg taken with meals, with adjustments made based on serum phosphate levels and individual response. The maximum daily dose can vary based on the patient's needs and the healthcare provider's recommendations.
Typical Dosing
FDA Approved Indications
- Control of serum phosphate levels in patients with chronic kidney disease on dialysis.
Who Shouldn't Take Renagel?
- Known hypersensitivity to sevelamer or any components of the formulation.
- Bowel obstruction or conditions that may lead to obstruction.
Advice From The Pharmacist
- Instruct patients to take Renagel with meals to maximize its phosphate-binding effects.
- Advise patients to follow a diet low in phosphate as recommended by their healthcare provider.
- Monitor for any gastrointestinal side effects, such as nausea or diarrhea, and report significant changes.
Side Effects of Renagel
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal pain
Uncommon/Severe Side Effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal pain
Risks and Warnings of Renagel
- Gastrointestinal Issues: Sevelamer can cause gastrointestinal adverse effects, so patients should be monitored for symptoms, especially during the initial treatment period.
- Nutrient Absorption: Renagel may interfere with the absorption of fat-soluble vitamins and other nutrients; regular monitoring of nutritional status is recommended.
Interactions with Renagel
Common Drug Interactions
- Medications with Phosphate: Caution is advised when using sevelamer with medications that contain phosphate, as this may affect the efficacy of Renagel.
- Other Medications: Some drugs may require dose adjustments or timing changes when taken with Renagel to ensure proper absorption.
Alternatives to Renagel
- Other Phosphate Binders: Such as lanthanum carbonate or calcium acetate, which may be considered based on individual patient needs and tolerance.
- Dietary Management: Implementing a low-phosphate diet may also help control serum phosphate levels.
