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Refissa
Refissa (tretinoin 0.05%) is a topical retinoid used primarily for the treatment of fine facial wrinkles, hyperpigmentation, and rough skin due to sun damage (photoaging). It belongs to the class of retinoids, which are derived from vitamin A and work by promoting skin cell turnover, helping to renew the skin’s appearance and texture. Refissa is commonly prescribed as part of an anti-aging skincare regimen.
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Frequently Asked Questions
Can I use Refissa during pregnancy?
No, Refissa should not be used during pregnancy as it may pose a risk to the developing fetus. Women who are pregnant or planning to become pregnant should avoid this medication.
Is it normal to experience peeling and irritation when using Refissa?
Yes, mild peeling and irritation are common side effects, especially during the first few weeks of treatment. These effects should decrease over time. If irritation persists, consult your healthcare provider.
Do I need to use sunscreen while on Refissa?
Yes, it is crucial to use a broad-spectrum sunscreen daily while using Refissa, as the medication can make your skin more sensitive to UV radiation and increase the risk of sunburn.
Can Refissa be used alongside other anti-aging products?
You should avoid using other exfoliating or irritating products, like those containing AHAs or BHAs, while using Refissa. Stick to gentle, non-irritating moisturizers and sunscreens. Always consult with your dermatologist before combining treatments.
Comprehensive Drug Guide
How Does Refissa Work?
Refissa works by stimulating the production of new skin cells and increasing the turnover of old, damaged skin cells. This process helps to reduce fine lines, lighten hyperpigmented areas, and improve skin texture by promoting collagen production and reducing keratinocyte cohesion, which leads to a smoother, more youthful appearance.
Common Dosages
- Cream: 0.05% concentration
Typical Dosing
- For photoaging: Apply a pea-sized amount of Refissa cream to the affected areas once daily in the evening, typically as part of a nighttime skincare routine. Results can take 3 to 6 months of consistent use to become noticeable.
Typical Dosing
FDA Approved Indications
- Fine wrinkles
- Hyperpigmentation (dark spots)
- Rough skin texture caused by sun damage
Who Shouldn't Take Refissa?
- Pregnancy: Tretinoin is not recommended during pregnancy due to potential teratogenic effects.
- Known hypersensitivity to tretinoin or any of the components in Refissa.
- Acute eczema or other active skin conditions that might worsen with retinoid use.
Advice From The Pharmacist
- Apply Refissa in the evening, after cleansing and drying the face. A pea-sized amount should be enough to cover the entire face. Avoid the eye area, nostrils, and mouth.
- Use a broad-spectrum sunscreen during the day while using Refissa, as tretinoin can make your skin more sensitive to sunlight.
- Some irritation, peeling, and redness are common in the first few weeks of treatment. These symptoms typically subside with continued use.
- If you experience severe irritation, decrease the frequency of application (e.g., every other night) or consult your dermatologist.
- Avoid using other harsh skin treatments, such as exfoliants or alcohol-based products, while using Refissa.
Side Effects of Refissa
Common Side Effects
- Skin redness
- Peeling
- Dryness
- Sensitivity to sunlight
Uncommon/Severe Side Effects
- Severe skin irritation
- Blistering or crusting of the skin
- Skin discoloration
Risks and Warnings of Refissa
- Photosensitivity: Refissa can make your skin more sensitive to sunlight, leading to a higher risk of sunburn. Always wear sunscreen and avoid prolonged sun exposure.
- Irritation and Peeling: Initial use of Refissa may cause irritation and peeling of the skin. These effects typically decrease with continued use but can be managed by reducing application frequency.
- Pregnancy: Tretinoin should not be used during pregnancy due to the risk of harm to the fetus. Women of childbearing age should use effective contraception while using Refissa.
Interactions with Refissa
Common Drug Interactions
- Other topical products: Avoid using products that contain alpha hydroxy acids (AHAs), beta hydroxy acids (BHAs), or benzoyl peroxide while using Refissa, as they can cause additional irritation.
- Medications that increase photosensitivity: Some medications, such as tetracyclines or thiazide diuretics, may increase the risk of photosensitivity reactions when combined with Refissa.
- Moisturizers: It is safe and often recommended to use a gentle moisturizer alongside Refissa to reduce dryness and irritation.
Alternatives to Refissa
- Renova (tretinoin): Another formulation of tretinoin used for similar purposes, available in different concentrations.
- Differin (adapalene): An over-the-counter retinoid used for acne and skin rejuvenation.
- Tazorac (tazarotene): A topical retinoid that treats acne and signs of photoaging.
- Over-the-counter retinol products: Weaker retinoid alternatives for skin rejuvenation, though less potent than prescription tretinoin.
