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Rasuvo
Rasuvo is a methotrexate injection used to treat several conditions, including rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), and psoriasis. It is also used in some cases to manage certain cancers, such as trophoblastic neoplasms. Methotrexate works as a disease-modifying antirheumatic drug (DMARD) and an antimetabolite, inhibiting cell growth and suppressing the immune system to control inflammation and reduce disease activity.
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Frequently Asked Questions
How long does it take for Rasuvo to work?
It may take several weeks to months to feel the full effects of Rasuvo, especially for conditions like rheumatoid arthritis or psoriasis.
Can Rasuvo be used during pregnancy?
No, Rasuvo should not be used during pregnancy, as it can cause birth defects and pregnancy loss. Effective contraception is required during treatment.
How is Rasuvo administered?
Rasuvo is given as a subcutaneous injection. Your healthcare provider will show you how to use the auto-injector, and it can be self-administered at home.
What should I do if I miss a dose?
If you miss a dose of Rasuvo, take it as soon as you remember unless it is close to your next scheduled dose. Do not take extra to make up for the missed dose.
Are there dietary restrictions while using Rasuvo?
You should avoid alcohol while using Rasuvo, as it can increase the risk of liver damage. Additionally, discuss folic acid supplementation with your healthcare provider to help reduce side effects.
Comprehensive Drug Guide
How Does Rasuvo Work?
Methotrexate, the active ingredient in Rasuvo, inhibits the enzyme dihydrofolate reductase, which is essential for DNA synthesis and cell replication. This action helps slow down the rapid division of cells, particularly those involved in inflammation and immune system overactivity, which is why it is effective in treating autoimmune diseases and certain cancers.
Common Dosages
- 7.5 mg to 30 mg, in 2.5 mg increments
Typical Dosing
- For rheumatoid arthritis and pJIA: The usual starting dose is 7.5 mg once weekly, which can be increased based on the patient’s response.
- For psoriasis: A typical dose is 10-25 mg once weekly.
- For cancer treatment: Doses and schedules vary based on the specific type of cancer and its severity.
Typical Dosing
FDA Approved Indications
- Rheumatoid arthritis (moderate to severe)
- Polyarticular juvenile idiopathic arthritis (pJIA)
- Psoriasis (severe, disabling forms)
- Trophoblastic neoplasms (gestational choriocarcinoma, chorioadenoma destruens, hydatidiform mole)
Who Shouldn't Take Rasuvo?
- Pregnancy: Methotrexate is teratogenic and should not be used during pregnancy.
- Liver disease or alcoholism
- Immunodeficiency syndromes
- Known hypersensitivity to methotrexate or any of its components
Advice From The Pharmacist
- Rasuvo is administered via subcutaneous injection. Make sure to rotate injection sites to avoid irritation.
- Methotrexate can cause serious side effects, so regular blood tests will be needed to monitor liver function, blood cell counts, and kidney function.
- Folic acid supplementation may be recommended to reduce the side effects of methotrexate, such as mouth sores and gastrointestinal discomfort.
- Avoid alcohol while using Rasuvo, as it can increase the risk of liver damage.
- Women of childbearing potential should use effective contraception during and after treatment due to the risk of birth defects.
Side Effects of Rasuvo
Common Side Effects
- Nausea and vomiting
- Stomach pain
- Mouth sores
- Fatigue
Uncommon/Severe Side Effects
- Liver toxicity
- Severe lung inflammation (pneumonitis)
- Bone marrow suppression (leading to low blood counts)
- Serious infections
Risks and Warnings of Rasuvo
- Hepatotoxicity: Rasuvo can cause liver damage, particularly in long-term use. Regular monitoring of liver function is necessary.
- Myelosuppression: Methotrexate can suppress bone marrow activity, leading to reduced blood cells and an increased risk of infections and bleeding.
- Lung Toxicity: Methotrexate has been associated with lung problems, including pneumonitis, which can be life-threatening.
- Pregnancy and Breastfeeding: Rasuvo should not be used during pregnancy or breastfeeding due to its teratogenic and toxic effects on infants.
Interactions with Rasuvo
Common Drug Interactions
- NSAIDs (e.g., ibuprofen, aspirin): May increase the risk of methotrexate toxicity.
- Antibiotics (e.g., penicillins, sulfonamides): Can reduce the clearance of methotrexate, leading to toxicity.
- Live vaccines: Should be avoided during methotrexate therapy, as the immune suppression can increase the risk of infection.
- Folic acid supplements: Can reduce some side effects but should be discussed with your healthcare provider before starting.
Alternatives to Rasuvo
- Otrexup: Another injectable form of methotrexate, used for similar conditions.
- Methotrexate oral tablets: An alternative form for patients who do not require injections.
- Leflunomide (Arava): Another DMARD used to treat rheumatoid arthritis.
- Enbrel (etanercept): A biologic DMARD used in cases where methotrexate is insufficient or not tolerated.
