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Quillivant XR
Quillivant XR is the brand name of a long-acting liquid formulation of methylphenidate. It is used to treat Attention Deficit Hyperactivity Disorder (ADHD) in both children and adults. Methylphenidate is a central nervous system (CNS) stimulant that works by affecting chemicals in the brain that contribute to hyperactivity and impulse control. Quillivant XR is designed for once-daily dosing, offering the benefit of extended release for continuous symptom management throughout the day.
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Frequently Asked Questions
How long does it take for Quillivant XR to start working?
Quillivant XR typically begins working within 45 minutes to an hour after taking it, with its effects lasting throughout the day due to its extended-release formulation.
Can Quillivant XR be taken with food?
Yes, Quillivant XR can be taken with or without food. However, taking it with food may help reduce stomach upset.
What should I do if I miss a dose of Quillivant XR?
If you miss a dose, take it as soon as you remember. However, if it's close to the next dose or later in the day, skip the missed dose to avoid sleep disturbances.
Is Quillivant XR safe for long-term use?
Quillivant XR is generally considered safe for long-term use when monitored by a healthcare provider. Regular check-ups are important to assess the effectiveness and any potential side effects.
Can Quillivant XR be used in adults with ADHD?
Yes, Quillivant XR is approved for use in adults with ADHD. It provides once-daily dosing, which can be convenient for adults managing their symptoms throughout the day.
Comprehensive Drug Guide
How Does Quillivant XR Work?
Quillivant XR works by inhibiting the reuptake of dopamine and norepinephrine in the brain, two neurotransmitters associated with attention and behavior. By increasing the concentration of these chemicals, the drug helps improve focus, reduce hyperactivity, and control impulsive behavior in individuals with ADHD.
Common Dosages
- 25 mg/5 mL (oral suspension)
Typical Dosing
- Children aged 6 and older: The typical starting dose is 20 mg once daily in the morning. The dose may be increased weekly in increments of 10 mg to 20 mg, with a maximum dose of 60 mg per day.
- Adults: Dosing in adults usually begins at 20 mg once daily, with adjustments as needed based on clinical response.
Typical Dosing
FDA Approved Indications
- Attention Deficit Hyperactivity Disorder (ADHD) in patients aged 6 years and older.
There are no widely recognized off-label uses for Quillivant XR.
Who Shouldn't Take Quillivant XR?
- Known hypersensitivity to methylphenidate or any components of the formulation.
- Individuals with severe anxiety, tension, or agitation, as the medication may exacerbate these conditions.
- Patients with a history of glaucoma or tics, including a family history of Tourette’s syndrome.
- Individuals currently taking monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing an MAOI due to the risk of hypertensive crisis.
Advice From The Pharmacist
- Quillivant XR should be taken once daily in the morning to avoid interference with sleep.
- Shake the bottle well for at least 10 seconds before measuring the dose, as the medication is a suspension.
- Store Quillivant XR in the refrigerator and discard any unused medication after 4 months.
- Avoid drinking alcohol while taking Quillivant XR, as it can enhance the side effects.
- Make sure your healthcare provider knows if you have a history of heart problems, as stimulants can increase blood pressure and heart rate.
Side Effects of Quillivant XR
Common Side Effects
- Decreased appetite
- Insomnia
- Nervousness or anxiety
- Nausea
- Stomach pain
Uncommon/Severe Side Effects
- Heart problems such as increased blood pressure and heart palpitations
- Psychiatric issues, such as new or worsening behavior and thought problems
- Circulation issues in fingers and toes, which may lead to numbness or coldness
Risks and Warnings of Quillivant XR
- Cardiovascular risks: Quillivant XR can raise blood pressure and heart rate. Patients with pre-existing heart conditions should use this medication with caution and under close medical supervision.
- Potential for abuse and dependence: Quillivant XR is a Schedule II controlled substance due to its stimulant properties, which can lead to abuse, dependence, and withdrawal symptoms.
- Psychiatric effects: The medication may cause or worsen pre-existing psychiatric conditions, such as anxiety, aggression, or mood swings.
Interactions with Quillivant XR
Common Drug Interactions
- MAO inhibitors: Combining Quillivant XR with MAOIs can result in a dangerous interaction, leading to high blood pressure or other serious effects.
- Antihypertensive medications: Quillivant XR may reduce the effectiveness of blood pressure medications.
- Antacids: Some antacids can affect the absorption of methylphenidate, altering its effectiveness.
- Alcohol: Drinking alcohol while taking Quillivant XR can intensify the side effects and potentially increase the release rate of the drug.
Alternatives to Quillivant XR
- Concerta (methylphenidate ER): Another long-acting form of methylphenidate available in tablet form for the treatment of ADHD.
- Adderall XR (amphetamine/dextroamphetamine): A stimulant medication used for ADHD and narcolepsy.
- Vyvanse (lisdexamfetamine): A stimulant used for ADHD and binge-eating disorder.
- Strattera (atomoxetine): A non-stimulant medication used to treat ADHD.
