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QUEtiapine Fumarate ER
QUEtiapine Fumarate ER (extended-release) is an atypical antipsychotic used to treat schizophrenia, bipolar disorder, and major depressive disorder (as an adjunct therapy). It helps manage symptoms such as hallucinations, delusions, mood swings, and depressive episodes. QUEtiapine Fumarate ER is designed for once-daily dosing, providing a sustained release of medication throughout the day. It affects neurotransmitters in the brain, particularly dopamine and serotonin, to stabilize mood and behavior.
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Frequently Asked Questions
How long does it take for QUEtiapine ER to work?
It may take several days to a few weeks to start noticing the effects of QUEtiapine ER, particularly for mood stabilization in bipolar disorder or schizophrenia. Full benefits may take longer.
Can QUEtiapine ER be used long-term?
Yes, QUEtiapine ER is often prescribed for long-term use in managing conditions like bipolar disorder and schizophrenia. Regular monitoring is important to manage any long-term side effects.
Should I avoid certain foods or drinks while taking QUEtiapine ER?
Avoid drinking alcohol while on QUEtiapine ER, as it can increase sedation and impair judgment. There are no specific food restrictions, but maintaining a healthy diet is important.
What should I do if I miss a dose?
Take the missed dose as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Comprehensive Drug Guide
How Does QUEtiapine Fumarate ER Work?
QUEtiapine ER blocks dopamine D2 receptors and serotonin 5-HT2 receptors in the brain. This dual action helps reduce the positive symptoms of schizophrenia (like hallucinations) and stabilizes mood in bipolar disorder. It also has some activity on histamine and adrenergic receptors, contributing to its calming and sedative effects.
Common Dosages
- 50 mg tablets
- 150 mg tablets
- 200 mg tablets
- 300 mg tablets
- 400 mg tablets
Typical Dosing
- For schizophrenia: Starting dose is 300 mg once daily, which can be increased up to 400–800 mg per day based on patient response.
- For bipolar disorder: Starting dose is 300 mg on day one, followed by an increase to 400 mg once daily.
- For major depressive disorder (adjunctive treatment): Starting dose is 50 mg once daily, which can be increased to 150–300 mg depending on the response.
Typical Dosing
FDA Approved Indications
- Schizophrenia in adults and adolescents
- Bipolar disorder (manic and depressive episodes)
- Adjunctive treatment for major depressive disorder in adults
Who Shouldn't Take QUEtiapine Fumarate ER?
- Known hypersensitivity to quetiapine or any of its ingredients
Advice From The Pharmacist
- Take QUEtiapine ER once daily, preferably in the evening, as it may cause drowsiness.
- Do not crush, chew, or split the extended-release tablets—swallow them whole to ensure proper release of the medication.
- Monitor your weight, blood sugar, and cholesterol levels regularly, especially if using this medication long-term.
- Be cautious with alcohol consumption, as it can increase the sedative effects of QUEtiapine ER.
Side Effects of QUEtiapine Fumarate ER
Common Side Effects
- Drowsiness
- Weight gain
- Dry mouth
- Dizziness
- Increased appetite
Uncommon/Severe Side Effects
- Tardive dyskinesia (involuntary muscle movements)
- Neuroleptic malignant syndrome (fever, muscle rigidity, altered mental state)
- Metabolic changes, such as elevated blood sugar or cholesterol
Risks and Warnings of QUEtiapine Fumarate ER
- Metabolic Effects: QUEtiapine ER can lead to increases in blood sugar, cholesterol, and weight gain, raising the risk for diabetes or heart disease.
- Sedation: It can cause significant drowsiness and sedation, particularly when taken in higher doses. Avoid activities that require alertness, such as driving, until you know how the medication affects you.
- Suicidal Thoughts: As with other antidepressants, there is a risk of suicidal thoughts in younger adults and adolescents, particularly during the initial phase of treatment.
Interactions with QUEtiapine Fumarate ER
Common Drug Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): These can increase the levels of QUEtiapine in the blood, leading to increased side effects.
- CNS depressants (e.g., alcohol, benzodiazepines): These can enhance the sedative effects of QUEtiapine ER, leading to excessive drowsiness or dizziness.
- Antihypertensive medications: QUEtiapine may enhance the blood pressure-lowering effects of these drugs, increasing the risk of hypotension.
Alternatives to QUEtiapine Fumarate ER
- Risperidone: Another atypical antipsychotic used for schizophrenia and bipolar disorder.
- Olanzapine: Another antipsychotic with similar indications, though with a higher risk of weight gain and metabolic side effects.
- Aripiprazole: A different atypical antipsychotic with a slightly different side effect profile, used for similar conditions.
