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QUEtiapine Fumarate
QUEtiapine Fumarate is an atypical antipsychotic medication used to treat conditions such as schizophrenia, bipolar disorder, and major depressive disorder (as an adjunctive treatment). It works by affecting the levels of certain neurotransmitters in the brain, primarily dopamine and serotonin, which play a role in mood, thought processes, and behavior. QUEtiapine is commonly used to manage both manic and depressive episodes in bipolar disorder and is also prescribed for psychosis and severe anxiety.
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Frequently Asked Questions
How long does it take for QUEtiapine Fumarate to work?
It may take several days to a few weeks to start seeing the effects of QUEtiapine, especially for mood stabilization in bipolar disorder and depression.
Can QUEtiapine be used long-term?
Yes, QUEtiapine is commonly prescribed for long-term use in managing chronic conditions like bipolar disorder and schizophrenia. Regular monitoring by your healthcare provider is recommended to manage any long-term side effects.
Can I drink alcohol while taking QUEtiapine?
It is recommended to avoid alcohol while taking QUEtiapine, as it can increase the sedative effects and impair cognitive function.
Will QUEtiapine make me gain weight?
Weight gain is a common side effect of QUEtiapine, particularly with long-term use. It is important to monitor your diet and exercise regularly to help manage this side effect.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses
Comprehensive Drug Guide
How Does QUEtiapine Fumarate Work?
QUEtiapine works by antagonizing dopamine D2 receptors and serotonin 5-HT2 receptors in the brain. This dual action helps to stabilize mood, reduce hallucinations and delusions, and manage both manic and depressive symptoms. It also has some activity on histamine and adrenergic receptors, contributing to its sedative properties.
Common Dosages
- nded-release tablets (Seroquel XR): 50 mg, 150 mg, 200 mg, 300 mg, 400 mg
Typical Dosing
- For schizophrenia: Initial dose is 25 mg twice daily, gradually increased to 300-400 mg daily in divided doses.
- For bipolar disorder (mania): Starting dose is 50 mg twice daily, increased as needed to a target dose of 400-800 mg daily.
- For major depressive disorder: Typical adjunctive dose is 150-300 mg once daily, usually at bedtime.
Typical Dosing
FDA Approved Indications
- Schizophrenia (adults and adolescents)
- Bipolar disorder (manic and depressive episodes)
- Adjunctive treatment of major depressive disorder (in combination with other antidepressants)
Who Shouldn't Take QUEtiapine Fumarate?
- Known hypersensitivity to quetiapine or any of its ingredients
Advice From The Pharmacist
- Take QUEtiapine as prescribed, usually once or twice daily, depending on the formulation.
- Extended-release tablets should be taken whole, without crushing or chewing.
- Avoid activities that require mental alertness, such as driving, until you know how this medication affects you.
- Be aware that QUEtiapine can cause weight gain and increased blood sugar, especially in long-term use. Regular monitoring of weight, blood glucose, and cholesterol levels is advised.
- Do not stop taking QUEtiapine abruptly, as it can lead to withdrawal symptoms or a relapse in symptoms. Always consult your healthcare provider before making changes to your dosage.
Side Effects of QUEtiapine Fumarate
Common Side Effects
- Drowsiness
- Weight gain
- Dry mouth
- Dizziness
- Constipation
Uncommon/Severe Side Effects
- Tardive dyskinesia (involuntary movements)
- Neuroleptic malignant syndrome (fever, muscle stiffness, confusion)
- Increased risk of diabetes or high cholesterol
Risks and Warnings of QUEtiapine Fumarate
- Metabolic Changes: QUEtiapine can cause increases in blood sugar, cholesterol, and weight gain, leading to a higher risk of developing diabetes or heart disease.
- Sedation: This medication may cause significant drowsiness, especially in higher doses, so it should be used cautiously in people who need to remain alert.
- Suicidal Thoughts: Like many antidepressants and antipsychotics, QUEtiapine may increase the risk of suicidal thoughts in young adults and children during the initial phases of treatment.
Interactions with QUEtiapine Fumarate
Common Drug Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): May increase the levels of QUEtiapine in the blood, leading to increased side effects.
- CNS depressants (e.g., alcohol, benzodiazepines): May enhance the sedative effects of QUEtiapine, increasing the risk of drowsiness and dizziness.
- Antihypertensive medications: QUEtiapine may increase the effects of these medications, leading to low blood pressure (hypotension).
Alternatives to QUEtiapine Fumarate
- Risperidone: Another atypical antipsychotic used for schizophrenia, bipolar disorder, and irritability in autism.
- Olanzapine (Zyprexa®): Used for similar indications, with similar risks of weight gain and metabolic changes.
- Aripiprazole (Abilify®): Another atypical antipsychotic with a different mechanism of action, used for schizophrenia and bipolar disorder.
