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Qudexy XR
Qudexy XR is an extended-release formulation of topiramate, used to treat seizures in individuals with epilepsy and to prevent migraine headaches. Topiramate is an anticonvulsant that works by stabilizing electrical activity in the brain, helping to control seizures and reduce the frequency of migraines. Qudexy XR offers once-daily dosing, which can improve convenience and adherence to treatment.
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Frequently Asked Questions
How long does it take for Qudexy XR to work?
For seizure control, the effects of Qudexy XR may be noticeable within a few days to weeks. For migraine prevention, it may take several weeks to notice a reduction in the frequency of migraines.
Can Qudexy XR be taken with food?
Yes, Qudexy XR can be taken with or without food. If needed, the capsule contents can be sprinkled on soft food for easier administration.
What should I do if I miss a dose of Qudexy XR?
If you miss a dose, take it as soon as you remember unless it’s close to the next dose. Do not double the dose to make up for a missed one.
Is Qudexy XR safe during pregnancy?
Qudexy XR can increase the risk of birth defects, particularly cleft lip and palate, if taken during pregnancy. It should only be used during pregnancy if the benefits outweigh the risks.
Can Qudexy XR be used for conditions other than seizures or migraines?
Qudexy XR is primarily prescribed for seizures and migraines, but it may be used off-label for other conditions like bipolar disorder or weight management, though this should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Qudexy XR Work?
The exact mechanism of action of topiramate, the active ingredient in Qudexy XR, is not fully understood. However, it is believed to work by enhancing the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that calms nerve activity in the brain. It also blocks certain sodium and calcium channels, reducing the abnormal brain activity that leads to seizures and migraines.
Common Dosages
- 25 mg, 50 mg, 100 mg, 150 mg, 200 mg (extended-release capsules)
Typical Dosing
- For seizures: Initial dosing for adults and children typically starts at 25 mg to 50 mg once daily, with gradual increases by 25 mg to 50 mg weekly until reaching a maintenance dose. The maximum dose for seizure treatment may range from 200 mg to 400 mg daily.
- For migraine prevention: The typical dose for migraine prevention starts at 25 mg once daily, gradually increasing to 100 mg once daily as tolerated.
Typical Dosing
FDA Approved Indications
- Partial-onset seizures in adults and children aged 2 years and older
- Primary generalized tonic-clonic seizures
- Lennox-Gastaut syndrome (seizures associated with this condition)
- Migraine prevention in adults and adolescents aged 12 years and older
Who Shouldn't Take Qudexy XR?
- Hypersensitivity to topiramate or any ingredients in the formulation.
- Individuals with a history of metabolic acidosis without proper monitoring.
- Pregnancy, due to the risk of birth defects such as cleft lip and palate, unless the potential benefits outweigh the risks.
Advice From The Pharmacist
- Qudexy XR capsules can be taken whole or sprinkled on a small amount of soft food like applesauce. Do not chew the capsule or the sprinkled medication.
- It is important to drink plenty of water while taking Qudexy XR to reduce the risk of kidney stones.
- If you miss a dose, take it as soon as you remember unless it's close to the next dose. Do not double up on doses.
- Avoid alcohol, as it may increase the risk of side effects such as dizziness or drowsiness.
- Regular blood tests may be required to monitor for metabolic acidosis or other side effects.
Side Effects of Qudexy XR
Common Side Effects
- Tingling in the arms and legs (paresthesia)
- Loss of appetite
- Drowsiness or fatigue
- Weight loss
- Dizziness
Uncommon/Severe Side Effects
- Vision problems, including acute myopia and glaucoma
- Metabolic acidosis, which can cause increased breathing and fatigue
- Kidney stones
- Mood changes, including depression or suicidal thoughts
Risks and Warnings of Qudexy XR
- Vision problems: Topiramate may cause acute myopia and secondary angle-closure glaucoma, both of which require immediate medical attention.
- Metabolic acidosis: Qudexy XR can increase the risk of metabolic acidosis, which can affect bone health and kidney function.
- Birth defects: Qudexy XR has been associated with an increased risk of oral clefts in newborns if taken during pregnancy. Women of childbearing age should use effective contraception while taking this medication.
Interactions with Qudexy XR
Common Drug Interactions
- Oral contraceptives: Qudexy XR may reduce the effectiveness of hormonal birth control, so additional contraceptive methods may be necessary.
- Alcohol: Drinking alcohol while taking Qudexy XR can increase drowsiness and dizziness, and may also increase the risk of seizures.
- Other anticonvulsants: Qudexy XR may interact with other seizure medications, such as phenytoin or carbamazepine, requiring dose adjustments.
- Carbonic anhydrase inhibitors: Combining Qudexy XR with drugs like acetazolamide may increase the risk of kidney stones.
Alternatives to Qudexy XR
- Topamax (topiramate): The original brand version of topiramate, available in tablet form, for the treatment of seizures and migraines.
- Depakote (divalproex sodium): An anticonvulsant used to treat seizures, bipolar disorder, and migraine prevention.
- Zonegran (zonisamide): Another anticonvulsant used for seizure control.
- Amitriptyline: A medication used off-label for migraine prevention, especially when topiramate is not tolerated.
