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Pliaglis
Pliaglis (generic names: lidocaine and tetracaine) is a topical anesthetic cream used to numb the skin before certain medical or cosmetic procedures, such as laser treatments, dermal filler injections, or minor skin surgeries. It combines two local anesthetics, lidocaine and tetracaine, which work by blocking nerve signals in the skin to reduce pain. Pliaglis is commonly used to provide temporary numbness and prevent discomfort during these procedures.
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Frequently Asked Questions
How long does Pliaglis take to work?
Pliaglis takes approximately 20 to 60 minutes to numb the skin, depending on the procedure. The cream is usually left on for 30 to 60 minutes before being removed.
How long does the numbing effect of Pliaglis last?
The numbing effect of Pliaglis typically lasts for 1 to 2 hours after the cream is removed, providing sufficient time for the procedure to be completed.
Can I use Pliaglis at home?
Pliaglis should only be applied by a healthcare professional. It is not intended for home use.
Is Pliaglis safe for children?
Pliaglis has not been approved for use in children. It is typically used in adults undergoing medical or cosmetic procedures.
What should I do if I experience an allergic reaction to Pliaglis?
If you experience signs of an allergic reaction, such as rash, swelling, or difficulty breathing, seek immediate medical attention. Discontinue use of Pliaglis and inform your healthcare provider.
Comprehensive Drug Guide
How Does Pliaglis Work?
Pliaglis contains lidocaine and tetracaine, both of which are local anesthetics that block sodium channels in nerve cells, preventing the transmission of pain signals from the nerves in the skin to the brain. When applied to the skin, the cream numbs the area and temporarily reduces pain and discomfort during procedures.
Common Dosages
- 7% lidocaine
- 7% tetracaine
The cream is applied to the skin by a healthcare professional and left on for a designated amount of time before a procedure.
Typical Dosing
- A thick layer of Pliaglis is applied to intact skin at the treatment site and left on for approximately 20 to 30 minutes for minor procedures or 30 to 60 minutes for more invasive treatments.
- The cream forms a film on the skin and is then peeled off before the procedure begins.
- The amount of cream and duration of application depend on the size of the treatment area and the type of procedure being performed.
Typical Dosing
FDA Approved Indications
- Topical local anesthesia on intact skin for superficial dermatological procedures, such as laser treatments, dermal filler injections, and minor skin surgeries.
Who Shouldn't Take Pliaglis?
- Known hypersensitivity to lidocaine, tetracaine, or any other amide-type local anesthetics.
- Severe liver disease, as this can affect the metabolism of lidocaine and tetracaine.
Advice From The Pharmacist
- Pliaglis is applied by a healthcare provider, but it is important to inform your doctor if you have any history of allergic reactions to local anesthetics like lidocaine or tetracaine.
- Do not apply Pliaglis to broken or irritated skin, as this can increase absorption and the risk of systemic side effects.
- The cream should be applied in a thick, uniform layer, and the treatment area should remain undisturbed until it is peeled off.
- Avoid using other numbing agents or creams at the same time as Pliaglis, as this can increase the risk of side effects.
- After application, avoid touching or rubbing the treated area until the cream has been removed.
Side Effects of Pliaglis
Common Side Effects
- Redness or skin irritation at the application site
- Mild swelling or itching
- Temporary skin discoloration
Uncommon/Severe Side Effects
- Allergic reactions, such as rash, itching, swelling, or difficulty breathing
- Methemoglobinemia (a rare blood disorder that affects oxygen delivery in the body)
- Systemic toxicity, which can cause dizziness, confusion, blurred vision, or irregular heartbeat
Risks and Warnings of Pliaglis
- Systemic Toxicity: Although rare, applying too much Pliaglis or using it on large areas of skin can lead to systemic absorption, resulting in toxicity. Symptoms of systemic toxicity include dizziness, confusion, blurred vision, or seizures. If these symptoms occur, seek immediate medical attention.
- Methemoglobinemia: Pliaglis may cause a rare condition called methemoglobinemia, which reduces the oxygen-carrying capacity of the blood. Symptoms include blue or grayish skin, shortness of breath, and fatigue. If these symptoms occur, discontinue use and seek medical care.
- Allergic Reactions: Patients with a history of sensitivity to local anesthetics should avoid using Pliaglis, as it may cause an allergic reaction.
Interactions with Pliaglis
Common Drug Interactions
- Other topical anesthetics: Using Pliaglis with other local anesthetics can increase the risk of systemic absorption and toxicity. Inform your healthcare provider if you are using other topical numbing agents.
- Class I antiarrhythmic drugs (e.g., mexiletine): These drugs may increase the effects of lidocaine, leading to a higher risk of toxicity.
- Sulfonamides: Tetracaine may interact with sulfonamide antibiotics, increasing the risk of methemoglobinemia.
Alternatives to Pliaglis
- EMLA cream (lidocaine/prilocaine): Another topical anesthetic cream used to numb the skin before medical or cosmetic procedures.
- Lidocaine topical patches: These patches can be applied to the skin for localized pain relief or numbing before procedures.
- Zingo (lidocaine powder): A needle-free, lidocaine-containing device used to numb the skin before injections or minor procedures.
