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Pexeva
Pexeva (paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It is primarily used for the treatment of various psychiatric disorders, including major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder (OCD), and panic disorder. Pexeva works by increasing serotonin levels in the brain, which helps improve mood and reduce anxiety.
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Frequently Asked Questions
How long does it take for Pexeva to work?
Patients may begin to notice improvements in symptoms within 2 to 4 weeks, but optimal effects may take longer.
Can I take Pexeva with food?
Yes, Pexeva can be taken with or without food. Consistency in timing may enhance compliance
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up.
Is Pexeva safe during pregnancy?
Pexeva should be used during pregnancy only if the potential benefits justify the potential risks. Consult your healthcare provider for guidance.
Is Pexeva safe during pregnancy?
Pexeva should be used during pregnancy only if the potential benefits justify the potential risks. Consult your healthcare provider for guidance.
What are the signs of serious side effects to watch for?
Monitor for symptoms of severe allergic reactions or serotonin syndrome, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Pexeva Work?
Pexeva works by selectively inhibiting the reuptake of serotonin at the presynaptic neuron, which increases serotonin availability in the synaptic cleft. This action is believed to alleviate symptoms of depression and anxiety by enhancing serotonergic neurotransmission.
Common Dosages
- Tablets: Common strengths include 10 mg, 20 mg, 30 mg, and 40 mg.
Typical Dosing
- Adults: The usual starting dose for major depression or anxiety disorders is 20 mg once daily, which may be adjusted based on clinical response. The maximum recommended dose is 60 mg per day.
Typical Dosing
FDA Approved Indications
- Major depressive disorder
- Generalized anxiety disorder
- Social anxiety disorder
- Panic disorder
- Obsessive-compulsive disorder (OCD)
- Post-traumatic stress disorder (PTSD)
Who Shouldn't Take Pexeva?
- Known hypersensitivity to paroxetine or any component of the formulation.
- Use of monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI.
Advice From The Pharmacist
- Take Pexeva exactly as prescribed, and do not stop taking it abruptly without consulting your healthcare provider, as this may lead to withdrawal symptoms.
- Monitor for any changes in mood, behavior, or suicidal thoughts, especially when starting treatment or adjusting the dose.
- Inform your healthcare provider about all medications you are taking to avoid potential interactions.
Side Effects of Pexeva
Common Side Effects
- Nausea
- Drowsiness or fatigue
- Dry mouth
- Constipation
- Sexual dysfunction
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Serotonin syndrome (symptoms may include agitation, hallucinations, rapid heart rate, severe nausea or vomiting)
Risks and Warnings of Pexeva
- Suicidal Thoughts: Monitor for increased risk of suicidal thoughts or behavior, particularly in young adults and adolescents.
- Withdrawal Symptoms: Gradual tapering of the dose may be necessary to minimize withdrawal effects when discontinuing therapy.
Interactions with Pexeva
Common Drug Interactions
- Other SSRIs or SNRIs: Avoid concurrent use, as this may increase the risk of serotonin syndrome.
- Blood Thinners: Use caution when taking with anticoagulants, as Pexeva may increase bleeding risk.
Alternatives to Pexeva
- Other Antidepressants: Such as other SSRIs (e.g., fluoxetine, sertraline) or serotonin-norepinephrine reuptake inhibitors (SNRIs) like venlafaxine.
- Cognitive Behavioral Therapy (CBT): As a non-pharmacological approach to managing depression and anxiety.
