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Permethrin
Permethrin is a synthetic pyrethroid insecticide widely used for the treatment of scabies and lice infestations. It works by disrupting the nervous system of parasites, leading to their paralysis and death. Permethrin is available in topical formulations for direct application to the skin and hair.
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Frequently Asked Questions
How quickly does permethrin work?
Patients may notice relief from itching and irritation within a few days of treatment, but it may take longer for all symptoms to resolve.
Can I use permethrin on children?
Permethrin is safe for use in children aged 2 months and older. Consult a healthcare provider for appropriate use in younger children.
What should I do if I miss an application?
If you miss a dose, apply it as soon as you remember. Follow the prescribed schedule for future applications.
Is permethrin safe during pregnancy?
Permethrin is generally considered safe for use during pregnancy; however, consult your healthcare provider for personalized advice.
What are the signs of serious side effects to watch for?
Monitor for symptoms of severe allergic reactions or significant skin irritation, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Permethrin Work?
Permethrin is a synthetic pyrethroid insecticide widely used for the treatment of scabies and lice infestations. It works by disrupting the nervous system of parasites, leading to their paralysis and death. Permethrin is available in topical formulations for direct application to the skin and hair.
Common Dosages
Permethrin is typically available in the following forms:
- Topical cream: 5% for scabies.
- Topical lotion or shampoo: 1% for lice.
Typical Dosing
- For Scabies: Apply the cream to the entire body from the neck down, leaving it on for 8-14 hours before washing off. A second treatment may be necessary after 1 week.
- For Lice: Apply the lotion or shampoo to dry hair, leave on for 10 minutes, then rinse. A second treatment may be necessary after 7-10 days if live lice are still present.
Typical Dosing
FDA Approved Indications
- Treatment of scabies in patients aged 2 months and older.
- Treatment of head lice in patients aged 2 months and older.
Who Shouldn't Take Permethrin?
- Known hypersensitivity to permethrin or any component of the formulation
- Allergies to pyrethroids or pyrethrins
Advice From The Pharmacist
- Apply permethrin as directed, ensuring thorough coverage of the affected areas.
- For lice treatment, it is essential to comb the hair with a fine-toothed comb to remove dead lice and nits after treatment.
- Avoid contact with eyes, and wash hands thoroughly after application.
Side Effects of Permethrin
Common Side Effects
- Localized irritation (redness, itching, burning)
- Rash
Uncommon/Severe Side Effects
- Severe allergic reactions (swelling, difficulty breathing)
- Skin infections due to scratching
Risks and Warnings of Permethrin
- Skin Sensitivity: Use with caution in patients with sensitive skin or existing skin conditions.
- Reinfestation: Ensure that all household contacts are treated for lice or scabies to prevent reinfestation.
Interactions with Permethrin
Common Drug Interactions
Other Topical Products: Avoid using other topical treatments on the same area unless directed by a healthcare provider, as they may interfere with the effectiveness of permethrin.
Alternatives to Permethrin
- Other Antiparasitic Treatments: Such as ivermectin for scabies or malathion for lice.
- Non-pharmacologic Measures: Washing bedding and clothing in hot water to eliminate parasites.
