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Ivermectin
Ivermectin is an antiparasitic medication used to treat various infections caused by parasites. It is primarily prescribed for conditions such as onchocerciasis (river blindness), lymphatic filariasis, strongyloidiasis, and scabies. Ivermectin works by disrupting the nervous system and muscle function of parasites, leading to their paralysis and death.
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Frequently Asked Questions
How long does it take for Ivermectin to work?
The time it takes for Ivermectin to work depends on the condition being treated. For most infections, patients may start to notice improvements within a few days, but full treatment may take longer.
Can I take Ivermectin while pregnant?
Ivermectin should be used during pregnancy only if the benefits outweigh the risks. Consult your healthcare provider for personalized advice.
What should I do if I miss a dose of Ivermectin?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while taking Ivermectin?
There are no specific dietary restrictions while taking Ivermectin, but it's advisable to follow the healthcare provider's guidance.
Is Ivermectin safe for long-term use?
Ivermectin is generally safe for short-term use under medical supervision. Long-term use should be carefully monitored by a healthcare provider.
Comprehensive Drug Guide
How Does Ivermectin Work?
- Binding to specific ion channels in the membranes of parasites, leading to increased permeability.
- Causing paralysis and death of the parasites by interfering with neuromuscular transmission and causing paralysis of the muscles involved in movement.
Common Dosages
- Oral tablets: Usually available in 3 mg and 6 mg strengths.
- Topical formulations: Such as a 1% cream for scabies treatment.
Typical Dosing
- For onchocerciasis: The usual dose is 150 mcg/kg of body weight, taken as a single dose and repeated every 6 to 12 months as needed.
- For lymphatic filariasis: A single dose of 150 mcg/kg.
- For strongyloidiasis: 200 mcg/kg as a single dose, repeated after 1 to 2 weeks if necessary.
- For scabies: Apply the topical formulation to the affected area once and may be repeated in 1 week if needed.
Typical Dosing
FDA Approved Indications
- Treatment of onchocerciasis (river blindness)
- Treatment of lymphatic filariasis
- Treatment of strongyloidiasis (an intestinal infection caused by Strongyloides stercoralis)
- Topical treatment of scabies and head lice (as a lotion or cream)
Who Shouldn't Take Ivermectin?
- Known hypersensitivity to ivermectin or any components of the formulation.
- Meningitis or a history of neurological conditions such as epilepsy, as the safety in these populations is not well established.
Advice From The Pharmacist
- Take Ivermectin exactly as prescribed, and do not exceed the recommended dosage.
- For oral formulations, it can be taken with or without food; however, taking it with food may enhance absorption.
- Monitor for any adverse effects, such as dizziness or gastrointestinal symptoms, and report them to your healthcare provider.
- For topical use, apply a thin layer to the affected area and avoid contact with eyes and mouth.
Side Effects of Ivermectin
Common Side Effects
- Nausea
- Diarrhea
- Dizziness
- Fatigue
- Rash (especially with topical use)
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Neurological symptoms (such as seizures or confusion)
Risks and Warnings of Ivermectin
- Neurological Effects: Patients with certain parasitic infections, such as onchocerciasis, may experience Mazzotti reactions, which include fever, itching, and swollen lymph nodes after treatment. This is due to the death of adult worms.
- Drug Interactions: Inform your healthcare provider of all medications you are taking, as some drugs may interact with ivermectin.
Interactions with Ivermectin
Common Drug Interactions
- CYP3A4 Inhibitors: Drugs that inhibit this enzyme may increase ivermectin levels in the blood, potentially leading to increased side effects.
- Other Antiparasitic Drugs: Caution should be taken when combining ivermectin with other antiparasitic medications, as interactions may occur.
Alternatives to Ivermectin
- Albendazole: Another antiparasitic medication used for various worm infections.
- Mebendazole: Used primarily for intestinal worm infections.
- Permethrin: A topical treatment for scabies and lice.
