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Paxil CR
Paxil CR (paroxetine controlled release) is a selective serotonin reuptake inhibitor (SSRI) used primarily for the treatment of depression, anxiety disorders, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). The controlled-release formulation allows for once-daily dosing, providing a steady level of medication in the bloodstream.
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Frequently Asked Questions
How long does it take for Paxil CR to work?
Patients may begin to notice improvements in symptoms within 2 to 4 weeks, but full effects may take longer.
Can I take Paxil CR with food?
Yes, Paxil CR can be taken with or without food. Consistency in how you take it is important.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember on the same day. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up.
Is Paxil CR safe during pregnancy?
Paxil CR should be used during pregnancy only if the potential benefits justify the risks. Consult your healthcare provider for guidance.
What are the signs of serious side effects to watch for?
Monitor for symptoms of severe allergic reactions, serotonin syndrome, or changes in mood and behavior, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Paxil CR Work?
Paxil CR works by selectively inhibiting the reuptake of serotonin in the brain, which increases the availability of serotonin in the synaptic cleft. This action is believed to enhance mood and alleviate symptoms associated with depression and anxiety disorders.
Common Dosages
- Controlled-release tablets: Common strengths include 12.5 mg and 25 mg.
Typical Dosing
- Adults: The usual starting dose is 12.5 mg once daily, which may be increased to 25 mg after a week based on individual response and tolerability. The maximum recommended dose is 62.5 mg per day.
Typical Dosing
FDA Approved Indications
- Major depressive disorder
- Generalized anxiety disorder
- Social anxiety disorder
- Panic disorder
- Obsessive-compulsive disorder (OCD)
- Post-traumatic stress disorder (PTSD)
- Premenstrual dysphoric disorder (PMDD)
Who Shouldn't Take Paxil CR?
- Known hypersensitivity to paroxetine or any component of the formulation
- Use of monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI
Advice From The Pharmacist
- Take Paxil CR exactly as prescribed, and do not stop taking it abruptly without consulting your healthcare provider, as this may lead to withdrawal symptoms.
- Monitor for any changes in mood, behavior, or suicidal thoughts, especially when starting treatment or adjusting the dose.
- Inform your healthcare provider about all medications you are taking to avoid potential interactions.
Side Effects of Paxil CR
Common Side Effects
- Nausea
- Drowsiness
- Dizziness
- Dry mouth
- Sweating
- Sexual dysfunction
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Serotonin syndrome (symptoms may include agitation, hallucinations, rapid heart rate, severe nausea or vomiting)
Risks and Warnings of Paxil CR
- Suicidal Thoughts: Monitor for increased risk of suicidal thoughts or behavior, particularly in young adults and adolescents.
- Withdrawal Symptoms: Gradual tapering of the dose may be necessary to minimize withdrawal effects when discontinuing therapy.
Interactions with Paxil CR
Common Drug Interactions
- Other SSRIs or SNRIs: Avoid concurrent use, as this may increase the risk of serotonin syndrome.
- Blood Thinners: Use caution when taking with anticoagulants, as Paxil may increase bleeding risk.
Alternatives to Paxil CR
- Other Antidepressants: Such as other SSRIs (e.g., fluoxetine, sertraline) or serotonin-norepinephrine reuptake inhibitors (SNRIs) like venlafaxine.
- Cognitive Behavioral Therapy (CBT): As a non-pharmacological approach to managing depression and anxiety.
