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PARoxetine Mesylate
PARoxetine mesylate is a selective serotonin reuptake inhibitor (SSRI) primarily used to treat various psychiatric conditions, including major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder (OCD), and panic disorder. It functions by increasing serotonin levels in the brain, which helps improve mood and anxiety.
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Frequently Asked Questions
How long does it take for PARoxetine mesylate to work?
Patients may begin to notice improvements in symptoms within 2 to 4 weeks, but full effects may take longer.
Can I take PARoxetine mesylate with food?
Yes, PARoxetine mesylate can be taken with or without food.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up.
Is PARoxetine mesylate safe during pregnancy?
PARoxetine mesylate should be used during pregnancy only if the potential benefits justify the potential risks. Consult your healthcare provider for guidance.
What are the signs of serious side effects to watch for?
Monitor for symptoms of severe allergic reactions or serotonin syndrome, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does PARoxetine Mesylate Work?
PARoxetine mesylate works by selectively inhibiting the reuptake of serotonin at the presynaptic neuron, which increases serotonin availability in the synaptic cleft. This action is believed to alleviate symptoms of depression and anxiety by enhancing serotonergic neurotransmission.
Common Dosages
- Tablets: Common strengths include 10 mg, 20 mg, 30 mg, and 40 mg.
Typical Dosing
- Adults: The usual starting dose for major depression or anxiety disorders is 20 mg once daily, which may be adjusted based on clinical response. The maximum recommended dose is 60 mg per day.
Typical Dosing
FDA Approved Indications
- Major depressive disorder
- Generalized anxiety disorder
- Social anxiety disorder
- Panic disorder
- Obsessive-compulsive disorder (OCD)
- Post-traumatic stress disorder (PTSD)
- Premenstrual dysphoric disorder (PMDD)
Who Shouldn't Take PARoxetine Mesylate?
- Known hypersensitivity to paroxetine or any component of the formulation
- Use of monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI
Advice From The Pharmacist
- Take PARoxetine mesylate exactly as prescribed, and do not stop taking it abruptly without consulting your healthcare provider, as this may lead to withdrawal symptoms.
- Monitor for any changes in mood, behavior, or suicidal thoughts, especially when starting treatment or adjusting the dose.
- Inform your healthcare provider about all medications you are taking to avoid potential interactions.
Side Effects of PARoxetine Mesylate
Common Side Effects
- Nausea
- Drowsiness or fatigue
- Dry mouth
- Weight gain
- Sexual dysfunction
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Serotonin syndrome (symptoms may include agitation, hallucinations, rapid heart rate, severe nausea or vomiting)
Risks and Warnings of PARoxetine Mesylate
- Suicidal Thoughts: Monitor for increased risk of suicidal thoughts or behavior, particularly in young adults and adolescents.
- Withdrawal Symptoms: Gradual tapering of the dose may be necessary to minimize withdrawal effects when discontinuing therapy.
Interactions with PARoxetine Mesylate
Common Drug Interactions
- Other SSRIs or SNRIs: Avoid concurrent use, as this may increase the risk of serotonin syndrome.
- Blood Thinners: Use caution when taking with anticoagulants, as PARoxetine may increase bleeding risk.
Alternatives to PARoxetine Mesylate
- Other Antidepressants: Such as other SSRIs (e.g., fluoxetine, sertraline) or serotonin-norepinephrine reuptake inhibitors (SNRIs) like venlafaxine.
- Cognitive Behavioral Therapy (CBT): As a non-pharmacological approach to managing depression and anxiety.
