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PARoxetine HCl ER
Paroxetine HCl ER is an extended-release formulation of paroxetine, a selective serotonin reuptake inhibitor (SSRI) used primarily for the treatment of major depressive disorder, anxiety disorders, and other related conditions. The extended-release formulation allows for once-daily dosing, providing a steady release of medication over time.
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Frequently Asked Questions
How quickly does Paroxetine HCl ER work?
Patients may start to notice improvements in symptoms within 2 to 4 weeks, but it may take longer for the full effect to be realized.
Can I take Paroxetine HCl ER with food?
Yes, it can be taken with or without food.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while using Paroxetine HCl ER?
There are no specific dietary restrictions while using Paroxetine HCl ER.
Is Paroxetine HCl ER safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Paroxetine HCl ER during these periods.
Comprehensive Drug Guide
How Does PARoxetine HCl ER Work?
Paroxetine works by selectively inhibiting the reuptake of serotonin in the brain, increasing serotonin levels in the synaptic cleft. This enhancement helps alleviate symptoms of depression and anxiety.
What is PARoxetine HCl ER Used For?
Common Dosages
- Extended-Release Tablets: Common strengths include 12.5 mg, 25 mg, and 37.5 mg.
Typical Dosing
- The usual starting dose for adults is 25 mg once daily, which may be adjusted based on clinical response, typically ranging from 12.5 mg to 62.5 mg daily.
Typical Dosing
FDA Approved Indications
- Major Depressive Disorder: for the treatment of depression in adults.
- Generalized Anxiety Disorder: for managing anxiety.
- Obsessive-Compulsive Disorder (OCD): for reducing obsessive thoughts and compulsive behaviors.
- Panic Disorder: for the treatment of panic attacks.
- Social Anxiety Disorder: for managing social phobia.
Off-Label Uses
Who Shouldn't Take PARoxetine HCl ER?
- Known hypersensitivity to paroxetine or any component of the formulation.
- Concurrent use of monoamine oxidase inhibitors (MAOIs) within the last 14 days.
- Pregnancy (especially in the third trimester due to potential risks to the newborn).
Advice From The Pharmacist
- Take Paroxetine HCl ER exactly as prescribed; do not stop taking it abruptly without consulting your healthcare provider, as this can lead to withdrawal symptoms.
- It may take several weeks to notice the full therapeutic effects.
- Inform your healthcare provider of any other medications you are taking to avoid potential drug interactions.
Side Effects of PARoxetine HCl ER
Common Side Effects
- Nausea
- Drowsiness
- Dizziness
- Dry mouth
- Sweating
Uncommon/Severe Side Effects
- Suicidal thoughts or behavior (especially in younger individuals)
- Serotonin syndrome (especially when combined with other serotonergic medications)
- Severe allergic reactions (rash, itching, swelling).
Risks and Warnings of PARoxetine HCl ER
- Increased Risk of Suicidal Thoughts: Monitor for any worsening mood or emergence of suicidal thoughts, especially in adolescents and young adults.
- Withdrawal Symptoms: Gradually tapering the dose is recommended if discontinuation is necessary to minimize withdrawal effects.
Interactions with PARoxetine HCl ER
Common Drug Interactions
- Other Antidepressants: Avoid combining with other serotonergic agents due to the risk of serotonin syndrome.
- Blood Thinners: Use with caution as paroxetine can increase the risk of bleeding.
Alternatives to PARoxetine HCl ER
- Other SSRIs: Such as fluoxetine, sertraline, or citalopram for managing major depressive disorder.
- SNRIs: Such as venlafaxine or duloxetine for depression and anxiety.
