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Osmolex ER
Osmolex ER (amantadine hydrochloride) is an extended-release medication primarily used to treat Parkinson's disease and drug-induced extrapyramidal symptoms (movement disorders) associated with the use of antipsychotic medications. It works by modulating dopamine receptors and has both dopaminergic and anticholinergic properties, helping to alleviate symptoms of rigidity and tremors.
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Frequently Asked Questions
How quickly will I see results with Osmolex ER?
Many patients may notice improvements in their symptoms within a few weeks of starting the medication, though individual responses can vary.
Can I take Osmolex ER with food?
Osmolex ER can be taken with or without food; however, consistency in how you take it can help with absorption.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up.
Is it safe to use Osmolex ER during pregnancy?
Osmolex ER should be used during pregnancy only if the potential benefits justify the potential risks. Consult your healthcare provider for guidance.
What are the signs of serious side effects to watch for?
Monitor for severe skin reactions, hallucinations, or significant mood changes, and contact your healthcare provider immediately if these occur.
Comprehensive Drug Guide
How Does Osmolex ER Work?
Osmolex ER works by increasing the availability of dopamine in the brain, which helps to improve motor control and reduce symptoms associated with Parkinson's disease. The extended-release formulation allows for a gradual release of the medication over time, providing more stable blood levels and minimizing fluctuations in symptom control.
Common Dosages
- Extended-release tablets: 129 mg.
Typical Dosing
- Adults: The typical starting dose is 129 mg taken orally once daily, preferably in the morning. Dosage may be adjusted based on response and tolerability.
Typical Dosing
FDA Approved Indications
- Treatment of Parkinson's disease
- Management of drug-induced extrapyramidal symptoms
Who Shouldn't Take Osmolex ER?
- Known hypersensitivity to amantadine or any component of the formulation
- Uncontrolled seizures
- History of hypersensitivity reactions, including those with a history of skin reactions
Advice From The Pharmacist
- Take Osmolex ER exactly as prescribed and do not exceed the recommended dose.
- Gradual dose adjustments may be necessary; consult your healthcare provider for any changes.
- Be aware of potential side effects, including dizziness or drowsiness, and avoid activities that require full alertness until you know how the medication affects you.
- Monitor for any unusual side effects, such as skin reactions, and report them to your healthcare provider.
Side Effects of Osmolex ER
Common Side Effects
- Dizziness
- Drowsiness
- Dry mouth
- Nausea
- Insomnia
Uncommon/Severe Side Effects
- Severe skin reactions (e.g., rash, swelling)
- Hallucinations or confusion
- Unusual behavioral changes
Risks and Warnings of Osmolex ER
- Cognitive Effects: Osmolex ER may cause cognitive or mood changes; patients should be monitored for any significant changes in behavior or mood.
- Seizure Risk: Caution is advised in patients with a history of seizures or epilepsy, as amantadine may lower the seizure threshold.
- Kidney Function: Dosage adjustments may be necessary for patients with renal impairment, and regular monitoring is recommended.
Interactions with Osmolex ER
Common Drug Interactions
- Other Dopaminergic Agents: Caution is advised when used in combination with other medications that affect dopamine levels.
- CNS Depressants: Use with caution, as concurrent use may enhance sedation and drowsiness.
Alternatives to Osmolex ER
- Other Parkinson's Disease Treatments: Such as levodopa/carbidopa or dopamine agonists for more comprehensive management of Parkinson's symptoms.
- Anticholinergic Medications: Such as trihexyphenidyl for the treatment of extrapyramidal symptoms.
