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NovoLOG Mix 70/30
NovoLOG Mix 70/30 (generic name: insulin aspart protamine and insulin aspart) is a premixed insulin used to control blood sugar levels in people with type 1 and type 2 diabetes mellitus. It is a combination of 70% insulin aspart protamine (an intermediate-acting insulin) and 30% insulin aspart (a rapid-acting insulin). NovoLOG Mix 70/30 is designed to provide a balance between immediate control of blood sugar spikes after meals and sustained control of blood sugar throughout the day.
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Frequently Asked Questions
How quickly does NovoLOG Mix 70/30 start working?
NovoLOG Mix 70/30 starts to work within 15 minutes of injection, making it important to administer it right before meals.
Can I use NovoLOG Mix 70/30 with oral diabetes medications?
Yes, NovoLOG Mix 70/30 can be used in combination with oral diabetes medications. However, your healthcare provider may adjust your dosage to ensure proper blood sugar control.
How should I store my NovoLOG Mix 70/30 FlexPen after opening?
After opening, the FlexPen can be stored at room temperature (below 86°F) and should be used within 28 days. Unopened pens should be stored in the refrigerator.
What should I do if I miss a dose of NovoLOG Mix 70/30?
If you miss a dose, consult your healthcare provider for advice. Do not inject extra insulin to make up for a missed dose, as this may cause hypoglycemia.
Can I travel with NovoLOG Mix 70/30?
Yes, you can travel with NovoLOG Mix 70/30, but be sure to keep it cool and away from direct sunlight. Carry a medical note and supplies for blood sugar monitoring during travel.
Comprehensive Drug Guide
How Does NovoLOG Mix 70/30 Work?
NovoLOG Mix 70/30 works by mimicking the body’s natural insulin response. The rapid-acting insulin aspart quickly lowers blood sugar levels after meals, while the intermediate-acting insulin aspart protamine provides a longer duration of action to control blood sugar levels between meals and overnight. This combination helps manage both postprandial (after meal) and basal (ongoing) blood glucose levels.
Common Dosages
- Vials: For use with syringes
- Pre-filled FlexPen®: 3 mL pen delivering insulin doses
Typical Dosing
- The dosing of NovoLOG Mix 70/30 is individualized based on the patient’s blood sugar levels, meals, and physical activity.
- It is typically injected twice daily, within 15 minutes before a meal, but dosing schedules can vary based on patient needs and medical advice.
Typical Dosing
FDA Approved Indications
- Type 1 diabetes mellitus
- Type 2 diabetes mellitus in adults who require insulin to control blood sugar levels.
Who Shouldn't Take NovoLOG Mix 70/30?
- Hypoglycemia (low blood sugar)
- Known hypersensitivity to insulin aspart or any of the ingredients in the formulation
Advice From The Pharmacist
- Inject NovoLOG Mix 70/30 15 minutes before meals to effectively manage post-meal blood sugar spikes.
- Rotate injection sites between the abdomen, thigh, and upper arm to prevent lipodystrophy (thickening or thinning of fat tissue).
- Store unopened vials and FlexPen devices in the refrigerator, but once opened, they can be stored at room temperature for up to 28 days.
- Do not freeze the insulin, and keep it away from direct sunlight or heat.
- Regularly monitor your blood sugar levels and report any extreme highs or lows to your healthcare provider.
Side Effects of NovoLOG Mix 70/30
Common Side Effects
- Hypoglycemia (low blood sugar)
- Injection site reactions (redness, swelling, or itching)
- Weight gain
Uncommon/Severe Side Effects
- Severe hypoglycemia, which can cause unconsciousness or seizures
- Severe allergic reactions (rash, swelling, difficulty breathing)
Risks and Warnings of NovoLOG Mix 70/30
- Risk of Hypoglycemia: NovoLOG Mix 70/30 can cause low blood sugar, especially if meals are delayed, skipped, or if more insulin is injected than needed. Be sure to carry a source of fast-acting glucose (like glucose tablets or juice) to treat low blood sugar episodes.
- Allergic Reactions: Seek immediate medical attention if you experience any signs of an allergic reaction, such as swelling, rash, or difficulty breathing.
- Insulin Mixing: Do not mix NovoLOG Mix 70/30 with other insulins in the same syringe or pen.
Interactions with NovoLOG Mix 70/30
Common Drug Interactions
- Oral diabetes medications (e.g., metformin): These may affect blood sugar control when used alongside insulin.
- Beta-blockers: Can mask the symptoms of hypoglycemia, making it harder to detect low blood sugar.
- Steroids and diuretics: May increase blood sugar levels, requiring insulin dose adjustments.
Alternatives to NovoLOG Mix 70/30
- Humalog Mix 75/25: A similar premixed insulin containing insulin lispro and insulin lispro protamine.
- Novolin 70/30: Another premixed insulin containing regular human insulin and NPH insulin.
- Basal-bolus insulin regimen: A combination of separate long-acting and rapid-acting insulins to achieve individualized blood sugar control.
