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Nitrostat
Nitrostat is the brand name for nitroglycerin, a medication used to treat episodes of chest pain (angina) in people with coronary artery disease. It belongs to the drug class known as nitrates, which help widen blood vessels to increase blood flow and oxygen to the heart, reducing the heart's workload. Nitrostat is typically used during the onset of angina to relieve pain or before activities that may cause chest pain, such as exercise.
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Frequently Asked Questions
How quickly does Nitrostat work?
Nitrostat usually starts to relieve chest pain within 1 to 3 minutes. If you do not feel relief after 5 minutes, you can take another dose, up to three tablets total.
Can I use Nitrostat daily?
Nitrostat is typically used as needed for angina attacks or before activities that may cause chest pain. It is not meant to be taken on a regular daily schedule unless directed by your doctor.
What should I do if I accidentally swallow the tablet?
Nitrostat is designed to be taken sublingually (under the tongue). If swallowed, it may not be as effective. Contact your healthcare provider if this happens and follow their advice.
Can Nitrostat prevent a heart attack?
Nitrostat helps relieve angina (chest pain), but it does not prevent heart attacks. If you suspect you're having a heart attack (persistent chest pain, shortness of breath), seek emergency medical help immediately.
Can I take Nitrostat with other heart medications?
You can take Nitrostat with some heart medications, but certain drugs (like phosphodiesterase inhibitors for erectile dysfunction) should be avoided. Always check with your doctor or pharmacist before combining Nitrostat with other medications.
Comprehensive Drug Guide
How Does Nitrostat Work?
Nitrostat works by relaxing the smooth muscles of the blood vessels, causing them to dilate (widen). This process, known as vasodilation, reduces the amount of oxygen the heart needs by decreasing its workload. In turn, this helps relieve the symptoms of angina, such as chest pain or tightness, by improving blood flow to the heart muscle.
Common Dosages
- Sublingual tablets: 0.3 mg, 0.4 mg, 0.6 mg per tablet
- Available in bottles containing 25 or 100 tablets
Typical Dosing
- For relief of angina: Place one tablet under the tongue at the onset of chest pain. If pain persists after 5 minutes, another tablet may be used. A maximum of three tablets can be taken within 15 minutes.
- For prevention of angina before activities: Take one tablet 5 to 10 minutes before the activity begins.
Typical Dosing
FDA Approved Indications
- Acute relief of angina pectoris (chest pain due to coronary artery disease)
- Prevention of angina during activities that may cause angina (exercise or stress)
Who Shouldn't Take Nitrostat?
- Severe anemia
- Increased intracranial pressure (e.g., due to head injury or cerebral hemorrhage)
- Hypotension (low blood pressure)
- Use of phosphodiesterase inhibitors like sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra), as this can lead to dangerously low blood pressure
Advice From The Pharmacist
- Take Nitrostat exactly as prescribed by your doctor. Do not chew or swallow the tablet; place it under your tongue and let it dissolve completely.
- Always carry Nitrostat with you in its original container, as it may lose effectiveness if exposed to air, light, or moisture for too long.
- Avoid abrupt movements, such as standing up quickly, after taking Nitrostat, as it may cause dizziness due to a drop in blood pressure.
- If you experience no relief after three doses, seek emergency medical help immediately, as it may indicate a more serious heart condition like a heart attack.
Side Effects of Nitrostat
Common Side Effects
- Headache (often due to blood vessel dilation)
- Dizziness or lightheadedness
- Flushing (warmth, redness, or tingly feeling)
Uncommon/Severe Side Effects
- Severe low blood pressure (hypotension)
- Rapid heartbeat (tachycardia) or slow heartbeat (bradycardia)
- Fainting or loss of consciousness
Risks and Warnings of Nitrostat
- Hypotension Risk: Nitrostat can cause significant drops in blood pressure, leading to dizziness or fainting. This risk is heightened in individuals who are dehydrated or on medications like diuretics.
- Interaction with Erectile Dysfunction Medications: Do not take Nitrostat if you are using medications for erectile dysfunction (like Viagra), as this can result in life-threatening hypotension.
- Overuse: Excessive use of Nitrostat can result in tolerance, meaning the medication may become less effective over time.
Interactions with Nitrostat
Common Drug Interactions
- Phosphodiesterase inhibitors (sildenafil, tadalafil, vardenafil): Combining these medications with Nitrostat can cause dangerously low blood pressure.
- Alcohol: Drinking alcohol while taking Nitrostat can increase the risk of dizziness, fainting, or low blood pressure.
- Blood pressure medications: Some antihypertensive drugs may enhance the blood-pressure-lowering effects of Nitrostat, requiring monitoring.
Alternatives to Nitrostat
- Isosorbide mononitrate: Another nitrate medication used for angina prevention.
- Isosorbide dinitrate: Similar to Nitrostat, used for angina relief and prevention.
- Ranexa (ranolazine): An antianginal agent used for chronic angina management.
- Beta-blockers: Drugs like atenolol or metoprolol can also be used to prevent angina.
