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Nitro-Dur
Nitro-Dur (generic name: nitroglycerin) is a transdermal patch used to prevent angina pectoris (chest pain) caused by coronary artery disease. It delivers a continuous dose of nitroglycerin through the skin, helping to dilate blood vessels, which improves blood flow and reduces the workload on the heart.
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Frequently Asked Questions
How quickly does Nitro-Dur work?
Nitro-Dur may take several hours to achieve steady-state levels, but patients often experience relief from angina within 30 minutes to 1 hour after applying the patch.
Can I take Nitro-Dur with food?
Yes, Nitro-Dur can be used with or without food; however, it is important to follow the prescribed application regimen.
What should I do if I miss a dose?
If you miss a patch, apply it as soon as you remember. If it’s close to the time for your next patch application, skip the missed dose and continue with your regular schedule.
Are there any dietary restrictions while using Nitro-Dur?
There are no specific dietary restrictions while using Nitro-Dur.
Is Nitro-Dur safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Nitro-Dur during these periods.
Comprehensive Drug Guide
How Does Nitro-Dur Work?
Nitroglycerin works by converting to nitric oxide in the body, which relaxes and dilates blood vessels (both veins and arteries). This vasodilation decreases preload and afterload on the heart, leading to reduced oxygen demand and relief from angina symptoms.
Common Dosages
- Transdermal Patch: Available in various strengths (e.g., 0.2 mg/hr, 0.4 mg/hr, 0.6 mg/hr, 0.8 mg/hr).
Typical Dosing
- The usual regimen involves applying one patch to a hairless area of the skin once daily, typically worn for 12 to 14 hours, followed by a 10 to 12 hour patch-free interval to minimize the development of tolerance.
Typical Dosing
FDA Approved Indications
- Angina Pectoris: for the prevention of angina attacks in patients with coronary artery disease.
Who Shouldn't Take Nitro-Dur?
- Known hypersensitivity to nitroglycerin or other nitrates.
- Severe anemia or hypotension.
- Concurrent use of phosphodiesterase inhibitors (e.g., sildenafil) due to the risk of severe hypotension.
Advice From The Pharmacist
- Apply Nitro-Dur to clean, dry, and hairless skin, and rotate application sites to minimize skin irritation.
- Avoid touching the patch with bare hands after application; wash hands after handling the patch.
- Monitor for side effects such as headache or dizziness, and report any severe reactions to a healthcare provider.
Side Effects of Nitro-Dur
Common Side Effects
- Headache
- Dizziness or lightheadedness
- Flushing
- Nausea
- Rapid heartbeat
Uncommon/Severe Side Effects
- Severe hypotension (low blood pressure)
- Fainting
- Allergic reactions (rash, itching, swelling).
Risks and Warnings of Nitro-Dur
- Hypotension: Monitor blood pressure closely, especially when initiating treatment or adjusting doses.
- Tolerance: Prolonged use may lead to tolerance; a patch-free interval is recommended to minimize this risk.
Interactions with Nitro-Dur
Common Drug Interactions
- Phosphodiesterase Inhibitors: Combining nitroglycerin with medications like sildenafil can cause severe hypotension.
- Other Antihypertensives: Caution is advised when using other medications that lower blood pressure.
Alternatives to Nitro-Dur
- Other Nitrates: Such as isosorbide dinitrate or isosorbide mononitrate for angina management.
- Calcium Channel Blockers: For angina and hypertension.
