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NIFEdipine ER Osmotic Release
NIFEdipine ER (extended-release) is a calcium channel blocker used primarily for the management of hypertension (high blood pressure) and chronic stable angina (chest pain). It helps to relax and widen blood vessels, thereby improving blood flow and reducing the heart's workload.
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Frequently Asked Questions
How quickly does NIFEdipine ER work?
NIFEdipine ER may start to lower blood pressure within 1 to 2 hours, but it may take several weeks for the full effects to be seen.
Can I take NIFEdipine ER with food?
Yes, NIFEdipine ER can be taken with or without food; however, consistency in how it is taken is important.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using NIFEdipine ER?
There are no specific dietary restrictions, but it is advisable to limit grapefruit juice.
Is NIFEdipine ER safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using NIFEdipine ER during these periods.
Comprehensive Drug Guide
How Does NIFEdipine ER Osmotic Release Work?
NIFEdipine works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac cells. This results in the relaxation of smooth muscle, leading to vasodilation, decreased peripheral vascular resistance, and reduced myocardial oxygen demand.
Common Dosages
- Extended-Release Tablets: 30 mg, 60 mg, and 90 mg.
Typical Dosing
- The usual starting dose for adults is 30 mg taken orally once daily, which may be increased based on blood pressure response. The maximum recommended dose is 90 mg per day.
Typical Dosing
FDA Approved Indications
- Hypertension: for the treatment of high blood pressure.
- Angina Pectoris: for the management of chronic stable angina.
Who Shouldn't Take NIFEdipine ER Osmotic Release?
- Known hypersensitivity to nifedipine or any component of the formulation.
- Severe hypotension (low blood pressure).
- Aortic stenosis or unstable angina.
Advice From The Pharmacist
- Take NIFEdipine ER exactly as prescribed, and do not crush or chew the extended-release tablets.
- Monitor blood pressure regularly to ensure effectiveness and adjust the dosage as necessary.
- Be cautious when engaging in activities that require alertness, as nifedipine may cause dizziness.
Side Effects of NIFEdipine ER Osmotic Release
Common Side Effects
- Headache
- Dizziness
- Flushing
- Peripheral edema (swelling of the limbs)
- Heartburn
Uncommon/Severe Side Effects
- Severe hypotension
- Worsening angina
- Allergic reactions (rash, itching, swelling).
Risks and Warnings of NIFEdipine ER Osmotic Release
- Hypotension: Monitor blood pressure closely, especially when initiating treatment or adjusting doses.
- Heart Function: Use with caution in patients with heart failure or significant aortic stenosis.
Interactions with NIFEdipine ER Osmotic Release
Common Drug Interactions
- Other Antihypertensives: Use caution when combined with other medications that lower blood pressure.
- Grapefruit Juice: May increase the levels of nifedipine; avoid excessive consumption.
Alternatives to NIFEdipine ER Osmotic Release
- Other Calcium Channel Blockers: Such as amlodipine or diltiazem for managing hypertension and angina.
- ACE Inhibitors: As alternative antihypertensive options.
