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NIFEdipine ER
NIFEdipine ER (extended-release) is a calcium channel blocker used primarily for the treatment of hypertension (high blood pressure) and chronic stable angina (chest pain). It works by relaxing blood vessels, improving blood flow, and reducing the heart's workload.
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Frequently Asked Questions
How quickly does NIFEdipine ER work?
NIFEdipine ER may start to lower blood pressure within 1 to 2 hours, but it may take several weeks for the full effects to be seen.
Can I take NIFEdipine ER with food?
Yes, NIFEdipine ER can be taken with or without food; however, consistency is important.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using NIFEdipine ER?
There are no specific dietary restrictions, but it is advisable to limit grapefruit juice.
Is NIFEdipine ER safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using NIFEdipine ER during these periods.
Comprehensive Drug Guide
How Does NIFEdipine ER Work?
NIFEdipine works by blocking calcium entry into vascular smooth muscle and cardiac cells. This leads to vasodilation, which decreases peripheral vascular resistance and reduces myocardial oxygen demand, helping to relieve angina symptoms and lower blood pressure.
Common Dosages
- Extended-Release Tablets: 30 mg, 60 mg, and 90 mg.
Typical Dosing
- The usual starting dose for adults is 30 mg taken orally once daily, which may be adjusted based on blood pressure response. The maximum recommended dose is 90 mg per day.
Typical Dosing
FDA Approved Indications
- Hypertension: for the treatment of high blood pressure.
- Angina Pectoris: for the management of chronic stable angina.
Who Shouldn't Take NIFEdipine ER?
- Known hypersensitivity to nifedipine or any component of the formulation.
- Severe hypotension (low blood pressure).
- Aortic stenosis or unstable angina.
Advice From The Pharmacist
- Take NIFEdipine ER exactly as prescribed, and do not crush or chew the extended-release tablets.
- Monitor blood pressure regularly to ensure effectiveness and adjust the dosage as necessary.
- Be cautious when engaging in activities that require alertness, as nifedipine may cause dizziness.
Side Effects of NIFEdipine ER
Common Side Effects
- Headache
- Dizziness
- Flushing
- Peripheral edema (swelling of the limbs)
- Fatigue
Uncommon/Severe Side Effects
- Severe hypotension
- Worsening angina
- Allergic reactions (rash, itching, swelling).
Risks and Warnings of NIFEdipine ER
- Hypotension: Monitor blood pressure closely, especially when starting treatment or adjusting doses.
- Heart Function: Use with caution in patients with heart failure or significant aortic stenosis.
Interactions with NIFEdipine ER
Common Drug Interactions
- Other Antihypertensives: Use caution when combined with other medications that lower blood pressure.
- Grapefruit Juice: May increase the levels of nifedipine; avoid excessive consumption.
Alternatives to NIFEdipine ER
- Other Calcium Channel Blockers: Such as amlodipine or diltiazem for managing hypertension and angina.
- ACE Inhibitors: As alternative antihypertensive options.
