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Neomycin-Polymyxin-Gramicidin
Neomycin-Polymyxin-Gramicidin is a combination topical antibiotic medication used to treat bacterial infections of the skin and ears. It contains three active ingredients: neomycin, polymyxin B, and gramicidin. This combination provides a broad spectrum of antibacterial activity, making it effective against various bacteria.
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Frequently Asked Questions
How quickly does Neomycin-Polymyxin-Gramicidin work?
Most patients begin to notice improvement in their symptoms within 2 to 3 days of starting treatment.
Can I use Neomycin-Polymyxin-Gramicidin with other topical medications?
Yes, but consult your healthcare provider before combining with other topical treatments to avoid irritation.
What should I do if I miss a dose?
If you miss a dose, apply it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule.
Are there any dietary restrictions while using Neomycin-Polymyxin-Gramicidin?
There are no specific dietary restrictions while using Neomycin-Polymyxin-Gramicidin.
Is Neomycin-Polymyxin-Gramicidin safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Neomycin-Polymyxin-Gramicidin during these periods.
Comprehensive Drug Guide
How Does Neomycin-Polymyxin-Gramicidin Work?
- Neomycin: An aminoglycoside antibiotic that inhibits bacterial protein synthesis, leading to bacterial cell death.
- Polymyxin B: A peptide antibiotic that disrupts the bacterial cell membrane, enhancing its antibacterial effects.
- Gramicidin: A polypeptide antibiotic that alters the permeability of bacterial cell membranes, further aiding in the destruction of bacteria.
Common Dosages
- Ointment or Cream: Commonly available in a formulation containing neomycin (0.5%), polymyxin B (10,000 units/mL), and gramicidin (0.025%).
Typical Dosing
- For skin infections: Apply a thin layer of Neomycin-Polymyxin-Gramicidin to the affected area 2 to 3 times daily, or as directed by a healthcare provider.
- For ear infections: Use as prescribed, typically involving a few drops applied to the affected ear.
Typical Dosing
FDA Approved Indications
- Bacterial Infections: for the treatment of superficial skin infections caused by susceptible bacteria.
- Otitis Externa: for the treatment of bacterial ear infections.
Who Shouldn't Take Neomycin-Polymyxin-Gramicidin?
- Known hypersensitivity to neomycin, polymyxin B, gramicidin, or any component of the formulation.
- Viral or fungal infections of the skin.
Advice From The Pharmacist
- Apply the medication as directed, and wash your hands before and after use.
- Avoid contact with the eyes, as it may cause irritation.
- If symptoms do not improve within a few days, or if they worsen, consult your healthcare provider.
Side Effects of Neomycin-Polymyxin-Gramicidin
Common Side Effects
- Local irritation or redness at the application site
- Itching or burning sensation
- Dryness of the skin
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Signs of superinfection (new infection developing).
Risks and Warnings of Neomycin-Polymyxin-Gramicidin
- Superinfection: Prolonged use of antibiotics can lead to the overgrowth of non-susceptible organisms, including fungi.
- Allergic Reactions: Monitor for signs of allergic reactions, especially in individuals with a history of sensitivities.
Interactions with Neomycin-Polymyxin-Gramicidin
Common Drug Interactions
- Other Topical Agents: Use with caution when combining with other topical treatments, as they may increase irritation.
- Systemic Corticosteroids: Caution is advised when used with systemic corticosteroids due to potential additive effects.
Alternatives to Neomycin-Polymyxin-Gramicidin
- Other Topical Antibiotics: Such as mupirocin or bacitracin for skin infections.
- Non-Antibiotic Topical Treatments: Depending on the nature of the skin condition.
