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Naproxen-Esomeprazole Mg

Naproxen-Esomeprazole Mg is a combination medication that includes naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and esomeprazole, a proton pump inhibitor (PPI). This combination is primarily used to relieve symptoms associated with osteoarthritis, rheumatoid arthritis, and other inflammatory conditions while reducing the risk of NSAID-associated gastric ulcers.



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Frequently Asked Questions

How quickly does Naproxen-Esomeprazole Mg work?
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Patients may start to notice relief from pain and inflammation within a few hours, but it may take longer for full effects to be realized.

Can I take Naproxen-Esomeprazole Mg with food?
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Yes, it can be taken with or without food, but taking it with food may help reduce gastrointestinal side effects.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.

Are there any dietary restrictions while using Naproxen-Esomeprazole Mg?
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There are no specific dietary restrictions, but it’s advisable to limit alcohol consumption due to increased gastrointestinal risk.

Is Naproxen-Esomeprazole Mg safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Naproxen-Esomeprazole Mg during these periods.

Comprehensive Drug Guide

How Does Naproxen-Esomeprazole Mg Work?

  • Naproxen works by inhibiting cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins that mediate inflammation, pain, and fever.
  • Esomeprazole reduces stomach acid production by inhibiting the proton pump in the stomach lining, helping to prevent gastric irritation and ulcers associated with NSAID use.


Common Dosages

  • Tablets: Commonly available doses include 375 mg/20 mg and 500 mg/20 mg.

Typical Dosing

  • The usual dosage is 1 tablet taken orally twice daily. Dosage may be adjusted based on the severity of symptoms and individual response.


Typical Dosing

FDA Approved Indications

  • Osteoarthritis: to relieve pain and inflammation.
  • Rheumatoid Arthritis: for the management of symptoms.
  • Other inflammatory conditions where NSAIDs are indicated and there is a need to reduce the risk of gastric ulcers.


Who Shouldn't Take Naproxen-Esomeprazole Mg?

  • Known hypersensitivity to naproxen, esomeprazole, or any component of the formulation.
  • Active gastrointestinal bleeding or ulcers.
  • Severe liver or kidney impairment.


Advice From The Pharmacist

  • Take Naproxen-Esomeprazole Mg exactly as prescribed, and do not exceed the recommended dosage.
  • Monitor for signs of gastrointestinal discomfort or bleeding, such as black or bloody stools.
  • Be aware of potential interactions with other medications, especially anticoagulants or other NSAIDs.


Side Effects of Naproxen-Esomeprazole Mg

Common Side Effects

  • Gastrointestinal disturbances (nausea, abdominal pain)
  • Dizziness
  • Headache
  • Diarrhea
  • Constipation


Uncommon/Severe Side Effects

  • Severe allergic reactions (rash, itching, swelling)
  • Gastrointestinal bleeding
  • Kidney dysfunction.


Risks and Warnings of Naproxen-Esomeprazole Mg

  • Gastrointestinal Risk: Long-term use of NSAIDs can increase the risk of gastrointestinal ulcers and bleeding.
  • Kidney Function: Monitor renal function regularly, especially in patients with existing kidney issues.


Interactions with Naproxen-Esomeprazole Mg

Common Drug Interactions

  • Anticoagulants: Increased risk of bleeding when used with blood thinners.
  • Other NSAIDs: Avoid concurrent use with other NSAIDs to reduce the risk of gastrointestinal complications.


Alternatives to Naproxen-Esomeprazole Mg

  • Other NSAIDs: Such as ibuprofen or diclofenac for pain management.
  • Non-NSAID Pain Relievers: Such as acetaminophen or alternative therapies for inflammation.