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Mirvaso
Mirvaso (generic name: brimonidine) is a topical gel used to treat facial erythema (redness) associated with rosacea in adults. It is an alpha-2 adrenergic agonist, which works by constricting the blood vessels in the skin, reducing the appearance of redness. Rosacea is a chronic skin condition that causes redness, flushing, and visible blood vessels, primarily on the face. Mirvaso helps to temporarily relieve the redness but does not cure the underlying condition.
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Frequently Asked Questions
How long does Mirvaso take to work?
You may begin to see a reduction in facial redness within 30 minutes of application, and the effects typically last for up to 12 hours.
Can I use Mirvaso more than once a day?
No, Mirvaso is typically used once daily. Overuse can increase the risk of side effects like rebound redness.
Is Mirvaso safe to use with makeup?
Yes, after applying Mirvaso and allowing it to dry, you can apply makeup over the treated areas. Make sure to apply a thin layer of the gel and allow it to fully absorb before applying other products.
What should I do if Mirvaso makes my redness worse?
If you experience rebound redness or worsening of your symptoms, stop using the medication and contact your healthcare provider for advice.
Can Mirvaso cure rosacea?
No, Mirvaso does not cure rosacea. It is used to temporarily reduce redness, and continued use is necessary to maintain the effects.
Comprehensive Drug Guide
How Does Mirvaso Work?
Mirvaso works by stimulating alpha-2 adrenergic receptors in the skin, which causes the constriction of blood vessels. This constriction reduces blood flow to the skin’s surface, temporarily diminishing the redness associated with rosacea. The effects of Mirvaso typically begin within 30 minutes of application and last for up to 12 hours.
Common Dosages
- Apply a pea-sized amount once daily to each of the five areas of the face: forehead, chin, nose, and each cheek.
Typical Dosing
- Once daily: Apply a thin layer of Mirvaso gel to the affected areas of the face.
- Be sure to use only a small amount (pea-sized) and avoid applying it to areas that are not affected by redness.
Typical Dosing
FDA Approved Indications
- Topical treatment of persistent facial erythema (redness) associated with rosacea in adults.
Who Shouldn't Take Mirvaso?
- Known hypersensitivity to brimonidine or any of the ingredients in the formulation.
- Severe cardiovascular disease, as it can cause a drop in blood pressure in rare cases.
- Depression or Raynaud's phenomenon, as the drug can worsen these conditions in certain individuals.
Advice From The Pharmacist
- Apply Mirvaso once daily, in a thin layer to the affected areas of the face. Avoid getting the gel in your eyes, mouth, or on mucous membranes.
- After application, wash your hands thoroughly.
- You may notice an improvement in redness within 30 minutes, with the effect lasting up to 12 hours.
- If you experience worsening redness or a burning sensation, contact your healthcare provider.
- Mirvaso should be stored at room temperature and kept out of direct sunlight.
Side Effects of Mirvaso
Common Side Effects
- Redness or flushing (rebound effect)
- Burning or stinging at the application site
- Dry skin
- Headache
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling, difficulty breathing)
- Low blood pressure or slow heart rate
- Worsening of redness (rebound effect) after the gel wears off
Risks and Warnings of Mirvaso
- Rebound Redness: Some patients may experience a worsening of facial redness (rebound erythema) after the effects of Mirvaso wear off. This can happen hours after application and may persist for some time. If this occurs, consult your healthcare provider.
- Cardiovascular Effects: Although rare, Mirvaso can lower blood pressure. Use caution if you have cardiovascular issues, including low blood pressure, Raynaud’s disease, or other circulatory problems.
- Depression and Mental Health: Mirvaso can exacerbate symptoms of depression in some patients. Use with caution in individuals with a history of mental health conditions.
Interactions with Mirvaso
Common Drug Interactions
- Blood pressure medications: Medications that affect blood pressure, such as beta-blockers or calcium channel blockers, may interact with Mirvaso, potentially leading to low blood pressure.
- Central nervous system depressants: Medications that depress the central nervous system, such as sedatives or antidepressants, may increase the risk of side effects like drowsiness or low blood pressure.
Alternatives to Mirvaso
- Rhofade (oxymetazoline): Another topical treatment for rosacea-related facial redness, it works by constricting blood vessels and is also used for temporary relief.
- Finacea (azelaic acid): A topical gel used to treat both the redness and pimples associated with rosacea.
- Metrogel (metronidazole): A topical antibiotic that can help reduce the inflammation and redness associated with rosacea.
