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Meclofenamate Sodium
Meclofenamate sodium is a nonsteroidal anti-inflammatory drug (NSAID) used primarily for the relief of mild to moderate pain and inflammation. It is often prescribed for conditions such as arthritis, dysmenorrhea (menstrual pain), and other inflammatory disorders. Meclofenamate works by inhibiting the enzymes involved in the production of prostaglandins, which are mediators of inflammation and pain.
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Frequently Asked Questions
How quickly does meclofenamate sodium work?
Patients may begin to feel relief within 30 minutes to 1 hour after taking the medication.
Can I take meclofenamate sodium with food?
Yes, it is recommended to take it with food or milk to help reduce gastrointestinal irritation.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember unless it’s close to your next scheduled dose. Do not double up doses.
Are there any dietary restrictions while using meclofenamate sodium?
There are no specific dietary restrictions, but maintaining a balanced diet is advisable, particularly if you are monitoring blood pressure or gastrointestinal health.
Is meclofenamate sodium safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using meclofenamate sodium.
Comprehensive Drug Guide
How Does Meclofenamate Sodium Work?
Meclofenamate sodium exerts its effects by inhibiting the cyclooxygenase (COX) enzymes (COX-1 and COX-2), which play a key role in converting arachidonic acid to prostaglandins. By decreasing the production of these inflammatory mediators, meclofenamate reduces pain, swelling, and fever.
Common Dosages
- Capsules: 50 mg and 100 mg.
- Oral Suspension: 25 mg/5 mL.
Typical Dosing
- The usual recommended dose for adults is 50 mg to 100 mg taken three times daily, as needed. The maximum daily dose should not exceed 400 mg.
- For menstrual pain, treatment may begin at the onset of symptoms.
Typical Dosing
FDA Approved Indications
- Relief of Mild to Moderate Pain: including pain associated with arthritis and menstrual cramps.
- Inflammatory Conditions: treatment of inflammatory disorders such as osteoarthritis and rheumatoid arthritis.
Who Shouldn't Take Meclofenamate Sodium?
- Known hypersensitivity to meclofenamate or any component of the formulation.
- History of gastrointestinal bleeding or ulcers.
- Severe renal or hepatic impairment.
Advice From The Pharmacist
- Take meclofenamate sodium with food or milk to minimize gastrointestinal irritation.
- Monitor for any signs of gastrointestinal bleeding, such as black or tarry stools.
- Use the lowest effective dose for the shortest duration necessary to manage symptoms.
Side Effects of Meclofenamate Sodium
Common Side Effects
- Nausea
- Diarrhea
- Indigestion
- Dizziness
- Headache
Uncommon/Severe Side Effects
- Gastrointestinal bleeding
- Kidney problems (reduced urine output, swelling)
- Severe allergic reactions (rash, itching, swelling)
Risks and Warnings of Meclofenamate Sodium
- Cardiovascular Risk: NSAIDs may increase the risk of heart attack and stroke; use with caution in patients with cardiovascular disease.
- Gastrointestinal Risk: NSAIDs can lead to serious gastrointestinal issues, including bleeding and perforation, particularly in older adults.
- Kidney Function: Monitor renal function in patients with pre-existing kidney disease or those on long-term therapy.
Interactions with Meclofenamate Sodium
Common Drug Interactions
- Other NSAIDs: Use caution when combining with other NSAIDs or aspirin to avoid increased risk of gastrointestinal side effects.
- Anticoagulants: NSAIDs can increase the risk of bleeding when taken with blood thinners.
- Diuretics: Meclofenamate sodium may reduce the effectiveness of certain diuretics.
Alternatives to Meclofenamate Sodium
- Other NSAIDs: Such as ibuprofen or naproxen for pain and inflammation management.
- Acetaminophen: For pain relief without the anti-inflammatory effects.
- Corticosteroids: For more severe inflammatory conditions under a healthcare provider's guidance.
