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Lidocaine-Prilocaine
Lidocaine-Prilocaine is a topical anesthetic combination used to provide localized numbing of the skin and mucous membranes. It is commonly used for procedures such as minor surgeries, needle insertions, and dermatological treatments. The formulation combines lidocaine and prilocaine, both of which are local anesthetics that work together to enhance pain relief.
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Frequently Asked Questions
How long does it take for Lidocaine-Prilocaine to start working?
Lidocaine-Prilocaine typically begins to numb the area within 30 minutes of application, with maximum effect occurring around 1 hour.
Can I take Lidocaine-Prilocaine with other medications?
Always consult your healthcare provider before combining Lidocaine-Prilocaine with other medications, especially topical products.
What should I do if I miss a dose of Lidocaine-Prilocaine?
If you miss a dose, apply it as soon as you remember. If it’s close to the time for your next scheduled application, skip the missed dose and continue with your regular schedule. Do not apply extra to compensate.
Is it safe to use Lidocaine-Prilocaine during pregnancy?
Lidocaine-Prilocaine should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.
Can Lidocaine-Prilocaine cause weight gain?
Weight gain is not commonly associated with Lidocaine-Prilocaine. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Lidocaine-Prilocaine Work?
Lidocaine and prilocaine work by blocking sodium channels in the neuronal membrane, preventing the initiation and conduction of nerve impulses. This action effectively numbs the area where the cream is applied, providing temporary relief from pain.
Common Dosages
- Topical cream: Common concentrations include 2.5% lidocaine and 2.5% prilocaine.
Typical Dosing
- The usual dosing involves applying a sufficient amount of the cream to the affected area 30 to 60 minutes before the procedure, allowing it to remain in place to achieve maximum effect.
Typical Dosing
FDA Approved Indications
- Topical anesthesia prior to minor surgical procedures.
- Numbing skin before injections or other invasive procedures.
Who Shouldn't Take Lidocaine-Prilocaine?
- Known hypersensitivity to lidocaine, prilocaine, or any components of the formulation
- Open wounds or damaged skin unless specifically directed by a healthcare provider
- A history of methemoglobinemia (a rare blood disorder)
Advice From The Pharmacist
- Patients should be advised to apply Lidocaine-Prilocaine only to intact skin and to wash their hands after application to avoid contact with the eyes or mucous membranes.
- Discuss the importance of not exceeding the recommended dosage and duration of use to avoid potential side effects.
- Encourage patients to report any signs of irritation or allergic reactions.
Side Effects of Lidocaine-Prilocaine
Common Side Effects
- Localized skin irritation
- Redness or swelling at the application site
- Numbness beyond the treated area
- Pale or bluish skin (rare, associated with methemoglobinemia)
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Systemic toxicity if absorbed in large amounts or used improperly
Risks and Warnings of Lidocaine-Prilocaine
- Methemoglobinemia Risk: Use with caution in patients with a history of methemoglobinemia or those who are taking medications that may increase the risk.
- Local Irritation: Monitor for any signs of irritation or allergic reaction, especially during initial use.
Interactions with Lidocaine-Prilocaine
Common Drug Interactions
Other Topical Anesthetics: Avoid concurrent use with other local anesthetics to reduce the risk of systemic toxicity.
Alternatives to Lidocaine-Prilocaine
- Other Topical Anesthetics: Such as benzocaine or lidocaine alone for similar applications.
- Oral Pain Relief: Over-the-counter analgesics like acetaminophen or ibuprofen for systemic pain relief.
